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The map label for this gene is nuoE [H]

Identifier: 85059576

GI number: 85059576

Start: 2745075

End: 2745608

Strand: Reverse

Name: nuoE [H]

Synonym: SG1598

Alternate gene names: 85059576

Gene position: 2745608-2745075 (Counterclockwise)

Preceding gene: 85059577

Following gene: 85059575

Centisome position: 65.82

GC content: 60.49

Gene sequence:

>534_bases
ATGCAGCAACAGCAAGATACCCCCAAGTATGCGGCGGCGGCGGGGCTGGACGCCGCCACCGAAACGTTCGAGCTGAGTCG
CGAAGAGCGCGAAGCCATCAAGCATGAGAAGCACCATTACGAGGATGCGCGCGCCGCCTCGATCGAAGCGCTGAAAATCG
TGCAGAAGAATCGCGGTTGGGTGCCGGACGGGGCCATCGCGGCTATCGCGCAGGTGCTGGGTATTCCCGGCAGCGATGTC
GAAGGGGTGGCCACGTTCTACAGCCAGATTTTCCGTCAGCCGGTGGGCCGCCATGTTATCCGCTATTGCGACAGCGTGGT
CTGCCATATTACCGGTTATCAGGGCATTCAGGCCGCGCTTGAGCAATCGCTGAACATTAAGCCGGGCCAGACTACGCCCG
ACGGGCGCTTCACCCTGCTGCCCACCTGCTGTCTGGGCAATTGCGACAAGGGACCGACCATGATGGTGGATGACGATACC
CACTTGCATCTGACACCGGAAGGTATTGGTCCGCTGCTGGAGCAATATCGATGA

Upstream 100 bases:

>100_bases
TGCAGCAAATCCCCTCGGTTATTCGCGGCAGCCTGGTATCGGATTTGATCGTATACCTGGGCAGTATTGATTTCGTTATG
TCAGATGTGGACCGCTAATT

Downstream 100 bases:

>100_bases
CCAAAACCATTGTCCGCTTGGCGGAAACGCACCCGCTGACCTGGCGGCTGCGCGATGACCATCAGCCGGTGTGGCTGGAC
GAATATCAGAGCAAAAACGG

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E; NUO5 [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MQQQQDTPKYAAAAGLDAATETFELSREEREAIKHEKHHYEDARAASIEALKIVQKNRGWVPDGAIAAIAQVLGIPGSDV
EGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEQSLNIKPGQTTPDGRFTLLPTCCLGNCDKGPTMMVDDDT
HLHLTPEGIGPLLEQYR

Sequences:

>Translated_177_residues
MQQQQDTPKYAAAAGLDAATETFELSREEREAIKHEKHHYEDARAASIEALKIVQKNRGWVPDGAIAAIAQVLGIPGSDV
EGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEQSLNIKPGQTTPDGRFTLLPTCCLGNCDKGPTMMVDDDT
HLHLTPEGIGPLLEQYR
>Mature_177_residues
MQQQQDTPKYAAAAGLDAATETFELSREEREAIKHEKHHYEDARAASIEALKIVQKNRGWVPDGAIAAIAQVLGIPGSDV
EGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEQSLNIKPGQTTPDGRFTLLPTCCLGNCDKGPTMMVDDDT
HLHLTPEGIGPLLEQYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=175, Percent_Identity=32.5714285714286, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI1788621, Length=158, Percent_Identity=85.4430379746835, Blast_Score=285, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17561328, Length=157, Percent_Identity=33.7579617834395, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355353, Length=157, Percent_Identity=31.8471337579618, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859877, Length=175, Percent_Identity=29.7142857142857, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19430; Mature: 19430

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQQDTPKYAAAAGLDAATETFELSREEREAIKHEKHHYEDARAASIEALKIVQKNRGW
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPDGAIAAIAQVLGIPGSDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAAL
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHH
EQSLNIKPGQTTPDGRFTLLPTCCLGNCDKGPTMMVDDDTHLHLTPEGIGPLLEQYR
HHHCCCCCCCCCCCCCEEEECHHHCCCCCCCCEEEEECCCEEEECCHHHHHHHHHCC
>Mature Secondary Structure
MQQQQDTPKYAAAAGLDAATETFELSREEREAIKHEKHHYEDARAASIEALKIVQKNRGW
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPDGAIAAIAQVLGIPGSDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAAL
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHH
EQSLNIKPGQTTPDGRFTLLPTCCLGNCDKGPTMMVDDDTHLHLTPEGIGPLLEQYR
HHHCCCCCCCCCCCCCEEEECHHHCCCCCCCCEEEEECCCEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]