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The map label for this gene is gapA [H]

Identifier: 85059325

GI number: 85059325

Start: 2240480

End: 2241487

Strand: Reverse

Name: gapA [H]

Synonym: SG1347

Alternate gene names: 85059325

Gene position: 2241487-2240480 (Counterclockwise)

Preceding gene: 85059328

Following gene: 85059324

Centisome position: 53.74

GC content: 54.17

Gene sequence:

>1008_bases
GTGGAATATATGACTATCAAAGTAGGTATCAACGGTTTTGGCCGTATCGGCCGTATTGTTTTCCGTGCTGCGCAGGAACG
TAACGACATCGAAATCGTTGCCATCAACGACCTGCTGGATGCTGATTATATGGCCTACATGCTGAAGTACGACTCGACCC
ACGGTCGCTTCAACGGTACCGTCGCCGTAGAGAACGGTCATCTGGTGGTCAACGGTAAAACCATCCGTTGTACCGCTGAG
AAGGATCCGGCTAACCTGAAATGGGGTGACGTCGGCGTAGACGTTGTCGCTGAAGCCACCGGCATCTTCCTGACCGACGA
AACGGCGCGTAAGCACATCACCGCCAGCGCCAAGAAAGTGGTACTGACCGGCCCGTCAAAAGATAACACGCCGATGTTTG
TCATGGGCGTTAACCACAAAGCCTATGATGGCCAGGATATCATTTCCAACGCCTCCTGTACCACCAACTGCCTGGCGCCG
CTGGCCAAAGTCATCAATGACAACTTCGGTATCGTTGAAGCCCTGATGACCACCGTTCACGCCACCACAGCTACTCAGAA
AACCGTTGACGGCCCGTCCCACAAGGACTGGCGCGGCGGCCGCGGCGCATCCCAGAACATCATCCCCTCCTCTACCGGCG
CGGCTAAAGCCGTGGGTAAAGTGATTCCCGAGCTGAACGGTAAACTGACCGGTATGTCCTTCCGCGTACCGACGCCGAAC
GTTTCAGTGGTCGACCTGACCGCGCGTCTGGAAAAACAGGCTTCCTATGAAGACATCTGCGCCGCCATCAAAAAAGCCGC
CGAAGGCGAGCTGAAAGGCGTGATGGGCTACACCGATGAAGACGTGGTGTCCACCGATTTCAACGGTGAAAAGCTGACCT
CCGTATTCGATGCCAAAGCAGGTATCGCGCTGAACGACAAATTTGTCAAACTGGTAGCCTGGTACGATAACGAAACGGGC
TATTCCAATAAAGTGTTGGATCTGATCTCCCATATCGCCAACAAATAA

Upstream 100 bases:

>100_bases
TCCGGATTGATTTGCCGCAACTATTGACACGATTCTGCTTGACGCTGCGCGAGGTTTTTGTAAATTTACAAGTAACCTTT
TATTCATTATTAAATAGCTG

Downstream 100 bases:

>100_bases
GCGTGGTGACCAGATGACGAAAGGGCGGCAGCGATGTCGCCCTTTTTCTTTTACTCAGGAGGTATATCATGTCCGACTCT
CTTCTTGCCTTGCCCGTCAA

Product: glyceraldehyde 3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH-A [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MEYMTIKVGINGFGRIGRIVFRAAQERNDIEIVAINDLLDADYMAYMLKYDSTHGRFNGTVAVENGHLVVNGKTIRCTAE
KDPANLKWGDVGVDVVAEATGIFLTDETARKHITASAKKVVLTGPSKDNTPMFVMGVNHKAYDGQDIISNASCTTNCLAP
LAKVINDNFGIVEALMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPN
VSVVDLTARLEKQASYEDICAAIKKAAEGELKGVMGYTDEDVVSTDFNGEKLTSVFDAKAGIALNDKFVKLVAWYDNETG
YSNKVLDLISHIANK

Sequences:

>Translated_335_residues
MEYMTIKVGINGFGRIGRIVFRAAQERNDIEIVAINDLLDADYMAYMLKYDSTHGRFNGTVAVENGHLVVNGKTIRCTAE
KDPANLKWGDVGVDVVAEATGIFLTDETARKHITASAKKVVLTGPSKDNTPMFVMGVNHKAYDGQDIISNASCTTNCLAP
LAKVINDNFGIVEALMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPN
VSVVDLTARLEKQASYEDICAAIKKAAEGELKGVMGYTDEDVVSTDFNGEKLTSVFDAKAGIALNDKFVKLVAWYDNETG
YSNKVLDLISHIANK
>Mature_335_residues
MEYMTIKVGINGFGRIGRIVFRAAQERNDIEIVAINDLLDADYMAYMLKYDSTHGRFNGTVAVENGHLVVNGKTIRCTAE
KDPANLKWGDVGVDVVAEATGIFLTDETARKHITASAKKVVLTGPSKDNTPMFVMGVNHKAYDGQDIISNASCTTNCLAP
LAKVINDNFGIVEALMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPN
VSVVDLTARLEKQASYEDICAAIKKAAEGELKGVMGYTDEDVVSTDFNGEKLTSVFDAKAGIALNDKFVKLVAWYDNETG
YSNKVLDLISHIANK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=332, Percent_Identity=67.1686746987952, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI7657116, Length=333, Percent_Identity=60.3603603603604, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI1788079, Length=330, Percent_Identity=86.969696969697, Blast_Score=599, Evalue=1e-173,
Organism=Escherichia coli, GI1789295, Length=329, Percent_Identity=39.8176291793313, Blast_Score=250, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17568413, Length=336, Percent_Identity=65.4761904761905, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI32566163, Length=336, Percent_Identity=65.4761904761905, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17534677, Length=336, Percent_Identity=63.0952380952381, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17534679, Length=336, Percent_Identity=63.0952380952381, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322409, Length=330, Percent_Identity=64.8484848484848, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321631, Length=330, Percent_Identity=64.2424242424242, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322468, Length=330, Percent_Identity=63.3333333333333, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17933600, Length=331, Percent_Identity=66.1631419939577, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI18110149, Length=331, Percent_Identity=66.1631419939577, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI85725000, Length=331, Percent_Identity=65.558912386707, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI22023983, Length=331, Percent_Identity=65.558912386707, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI19922412, Length=326, Percent_Identity=63.4969325153374, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36050; Mature: 36050

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYMTIKVGINGFGRIGRIVFRAAQERNDIEIVAINDLLDADYMAYMLKYDSTHGRFNGT
CCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCHHCHHHHEEEEEECCCCCEECCE
VAVENGHLVVNGKTIRCTAEKDPANLKWGDVGVDVVAEATGIFLTDETARKHITASAKKV
EEEECCEEEECCEEEEEECCCCCCCCEECCCCCEEEECCCEEEEECHHHHHHHCCCCCEE
VLTGPSKDNTPMFVMGVNHKAYDGQDIISNASCTTNCLAPLAKVINDNFGIVEALMTTVH
EEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPN
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECEEEECCCCC
VSVVDLTARLEKQASYEDICAAIKKAAEGELKGVMGYTDEDVVSTDFNGEKLTSVFDAKA
CEEEEHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCCCCCCEECCCCCHHHHHHHHCCC
GIALNDKFVKLVAWYDNETGYSNKVLDLISHIANK
CEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEYMTIKVGINGFGRIGRIVFRAAQERNDIEIVAINDLLDADYMAYMLKYDSTHGRFNGT
CCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCHHCHHHHEEEEEECCCCCEECCE
VAVENGHLVVNGKTIRCTAEKDPANLKWGDVGVDVVAEATGIFLTDETARKHITASAKKV
EEEECCEEEECCEEEEEECCCCCCCCEECCCCCEEEECCCEEEEECHHHHHHHCCCCCEE
VLTGPSKDNTPMFVMGVNHKAYDGQDIISNASCTTNCLAPLAKVINDNFGIVEALMTTVH
EEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPN
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECEEEECCCCC
VSVVDLTARLEKQASYEDICAAIKKAAEGELKGVMGYTDEDVVSTDFNGEKLTSVFDAKA
CEEEEHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCCCCCCEECCCCCHHHHHHHHCCC
GIALNDKFVKLVAWYDNETGYSNKVLDLISHIANK
CEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]