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The map label for this gene is sdaA [H]

Identifier: 85059306

GI number: 85059306

Start: 2208467

End: 2209831

Strand: Reverse

Name: sdaA [H]

Synonym: SG1328

Alternate gene names: 85059306

Gene position: 2209831-2208467 (Counterclockwise)

Preceding gene: 85059307

Following gene: 85059305

Centisome position: 52.98

GC content: 59.85

Gene sequence:

>1365_bases
GTGATCAGCGTTTTCGATATGTTCAAAATTGGTATTGGTCCGTCCAGTTCCCATACGGTAGGCCCGATGAAGGCCGGTAA
ACAATTTGTGGACGATTTGGTCGAAAAACATCTGCTGACGACCATCACCCGTATTGCCGTCGAGGTTTACGGCTCACTGG
CCCTGACCGGCAAAGGCCATCATACGGATCAGGCGATCATTCTCGGTCTGGCCGGCAACAGCCCGGATACGGTGGCTATC
GACGCAACGCCGGCCTTTTTGCGCGACGTGGCGGAGCGCGAGCGGCTGATGCTGGCGGGCACGCCCCATGAGGTGGATTT
CCCGCGCGAAGGCGGCATGGTGTTTCACCCCATGAATCTGGCGCGGCACGAAAACGGGCTGCGCATCCACGCCTTTGCGG
GAGACCGCTGCGTCTACAGCCAGACCTATTATTCGATCGGCGGCGGATTTATCGTCGAGGAAGCTCAGTTCGGCCAGGAG
GTGACCTGCGAGCTCAGCGTACCTTATTCTTTCAACAGCGCCCAGCAACTGCTGGACCATTGCCGCGATACGGCCTTGTC
GGTTTCCGGTCTGGTGCTGCGCAACGAGCTCGCGCTGCACGATCGTGCGGTGATAGACCAGTATTTCGCCAACGTCTGGC
AAACCATGCGAGCCTGTATTGATCGCGGCATGAATACCGAAGGCGTGCTGCCGGGGCCGCTTCGGGTGCCGCGCCGCGCC
GCCGCGCTCAGGAGGATGTTAATCGCAGGAGATAACCACTCTACCGACCCCATGCAGGTGGTAGACTGGGTCAATATGTT
CGCCCTGGCAGTCAATGAAGAGAATGCCGCCGGCGGACGGGTTGTCACCGCGCCCACTAACGGCGCCTGTGGCATCGTAC
CCACGGTCCTGGCTTACTACGACCATTTTATCGAACCCGTTTCGCCCGATATCTGGCTGCGGTATTTCCTCGCCAGCGGC
GCTATCGGGATGTTGTACAAGATGAACGCCTCGATTTCAGGCGCTGAAGTCGGCTGTCAGGGAGAGGTGGGCGTGGCGTG
CTCCATGGCCGCAGCCGGCCTGACGGAGCTGATGGGCGGCAGCCCGGAACAGGTCTGCGTCGCGGCAGAAATCGGCATGG
AGCACAATCTCGGCTTGACCTGCGATCCGGTGGGCGGTCAGGTGCAGGTACCCTGCATTGAGCGTAACGCTATCGCCTCG
GTTAAAGCGATCAACGCCTCACGCATGGCACTGCGCCGCACCAGCGCGCCGCGTGTATCCCTCGATAAGGTTATCGAAAC
CATGTACGAAACTGGCAAGGACATGAATGCCAAATACCGTGAAACCTCCCGTGGCGGCCTGGCTATCAAGGTACAGTGCG
ACTGA

Upstream 100 bases:

>100_bases
TTTATTTCATGCGAAAACGCACCTGTCATCCCCGTTCAACTATTACAATCAGGTCGATGCCACCTGCCCGTTGCCTTATA
AAATGTAAAGGAGAGCAAAC

Downstream 100 bases:

>100_bases
CGAGCAAGGCGTTGACCCCGTAAGCGTTTCGGCAACGTTCACGGGGTTATGGCGCTTCGGGGTTATTCTTCCTCATCCAT
ACCGTGCTGCGGCGCCAGTC

Product: L-serine deaminase

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVEKHLLTTITRIAVEVYGSLALTGKGHHTDQAIILGLAGNSPDTVAI
DATPAFLRDVAERERLMLAGTPHEVDFPREGGMVFHPMNLARHENGLRIHAFAGDRCVYSQTYYSIGGGFIVEEAQFGQE
VTCELSVPYSFNSAQQLLDHCRDTALSVSGLVLRNELALHDRAVIDQYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
AALRRMLIAGDNHSTDPMQVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPTVLAYYDHFIEPVSPDIWLRYFLASG
AIGMLYKMNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPEQVCVAAEIGMEHNLGLTCDPVGGQVQVPCIERNAIAS
VKAINASRMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Sequences:

>Translated_454_residues
MISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVEKHLLTTITRIAVEVYGSLALTGKGHHTDQAIILGLAGNSPDTVAI
DATPAFLRDVAERERLMLAGTPHEVDFPREGGMVFHPMNLARHENGLRIHAFAGDRCVYSQTYYSIGGGFIVEEAQFGQE
VTCELSVPYSFNSAQQLLDHCRDTALSVSGLVLRNELALHDRAVIDQYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
AALRRMLIAGDNHSTDPMQVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPTVLAYYDHFIEPVSPDIWLRYFLASG
AIGMLYKMNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPEQVCVAAEIGMEHNLGLTCDPVGGQVQVPCIERNAIAS
VKAINASRMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
>Mature_454_residues
MISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVEKHLLTTITRIAVEVYGSLALTGKGHHTDQAIILGLAGNSPDTVAI
DATPAFLRDVAERERLMLAGTPHEVDFPREGGMVFHPMNLARHENGLRIHAFAGDRCVYSQTYYSIGGGFIVEEAQFGQE
VTCELSVPYSFNSAQQLLDHCRDTALSVSGLVLRNELALHDRAVIDQYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
AALRRMLIAGDNHSTDPMQVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPTVLAYYDHFIEPVSPDIWLRYFLASG
AIGMLYKMNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPEQVCVAAEIGMEHNLGLTCDPVGGQVQVPCIERNAIAS
VKAINASRMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=81.057268722467, Blast_Score=776, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=455, Percent_Identity=72.967032967033, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=70.4194260485651, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48948; Mature: 48948

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVEKHLLTTITRIAVEVYGSLALTGKGH
CCCCEEEHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
HTDQAIILGLAGNSPDTVAIDATPAFLRDVAERERLMLAGTPHEVDFPREGGMVFHPMNL
CCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEECCHH
ARHENGLRIHAFAGDRCVYSQTYYSIGGGFIVEEAQFGQEVTCELSVPYSFNSAQQLLDH
HHCCCCCEEEEEECCEEEEECHHHCCCCCEEEEHHHCCCEEEEEEECCCCCCHHHHHHHH
CRDTALSVSGLVLRNELALHDRAVIDQYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
HHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRRMLIAGDNHSTDPMQVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPTVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIEPVSPDIWLRYFLASGAIGMLYKMNASISGAEVGCQGEVGVACSMAAAGLTELMGG
HHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRRTSAPRVS
CCCCEEEEEECCCCCCCCEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHCCCCCCC
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCCHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVEKHLLTTITRIAVEVYGSLALTGKGH
CCCCEEEHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
HTDQAIILGLAGNSPDTVAIDATPAFLRDVAERERLMLAGTPHEVDFPREGGMVFHPMNL
CCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEECCHH
ARHENGLRIHAFAGDRCVYSQTYYSIGGGFIVEEAQFGQEVTCELSVPYSFNSAQQLLDH
HHCCCCCEEEEEECCEEEEECHHHCCCCCEEEEHHHCCCEEEEEEECCCCCCHHHHHHHH
CRDTALSVSGLVLRNELALHDRAVIDQYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
HHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRRMLIAGDNHSTDPMQVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPTVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIEPVSPDIWLRYFLASGAIGMLYKMNASISGAEVGCQGEVGVACSMAAAGLTELMGG
HHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRRTSAPRVS
CCCCEEEEEECCCCCCCCEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHCCCCCCC
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCCHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]