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The map label for this gene is phoP [H]

Identifier: 85059060

GI number: 85059060

Start: 1790919

End: 1791590

Strand: Reverse

Name: phoP [H]

Synonym: SG1082

Alternate gene names: 85059060

Gene position: 1791590-1790919 (Counterclockwise)

Preceding gene: 85059061

Following gene: 85059059

Centisome position: 42.95

GC content: 52.08

Gene sequence:

>672_bases
ATGCGAGTTCTGGTAATAGAAGATAATTCTCTTCTTCGTCATCATCTGATGGTACAGATGCGTGAAATGGGGCACCAGGT
GGATGCCGCCGCGGACGCCCGGGAGGCGGACTACTTTCTAAATGAGCATCCACCCGATATCGCTATTGTCGATTTAGGCC
TGCCCGATGAGGACGGTCTCAATCTTATTCGCCGCTGGCGAAGCCATCAGGTGAAAATTCCCCTGCTGGTGCTCACTGCC
CGGGAAGGCTGGCAGGACAAAGTCACGGTTCTGGAAGCCGGCGCTGATGACTATGTCACAAAGCCTTTTCATCTGGAAGA
GGTGGTAGCACGCATGCAGGCGTTAATGCGCCGCAACAGCGGTCTGGCGTCGCAGGTTATCGAACTGCCACCTTTCCTCA
TTGATCTTTCGCGCCGTGAGCTTATGATTAATGAGGTTAATATCAGGCTCACTGCGTTTGAATATACCATTATCGAGACA
CTGATACGCAACGCCGGCAAAGTCGTCAGCAAGGATTCGCTGATGCTGCAACTTTATCCCGACGCTGAATTGCGCGAGAG
TCACACCATCGACGTGTTAATGGGGCGTCTGCGGAAAAAAATGCAGGCCAATTACCCGTATGAAGTGATCACCACAGTTC
GCGGTCAGGGCTACCGTTTTGATGTTAACTAG

Upstream 100 bases:

>100_bases
TCTTATCCGGTAAGATATTCCTTCCAACCGGGAGGATAACCGCTTAACAAGACGGATTGCGCCACCGGATCCGTTAAGGG
TGATTTTATTAGGAGCTGCA

Downstream 100 bases:

>100_bases
GCTCTATGACCCTATTTCCGTTACGCCACAAAAAACCGTTTTCCCTGCGCGTCAGATTCTTGCTGGCGGCAGCCTGCGTA
GTTCTGGCTCTCTCTCTGTG

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVIEDNSLLRHHLMVQMREMGHQVDAAADAREADYFLNEHPPDIAIVDLGLPDEDGLNLIRRWRSHQVKIPLLVLTA
REGWQDKVTVLEAGADDYVTKPFHLEEVVARMQALMRRNSGLASQVIELPPFLIDLSRRELMINEVNIRLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKMQANYPYEVITTVRGQGYRFDVN

Sequences:

>Translated_223_residues
MRVLVIEDNSLLRHHLMVQMREMGHQVDAAADAREADYFLNEHPPDIAIVDLGLPDEDGLNLIRRWRSHQVKIPLLVLTA
REGWQDKVTVLEAGADDYVTKPFHLEEVVARMQALMRRNSGLASQVIELPPFLIDLSRRELMINEVNIRLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKMQANYPYEVITTVRGQGYRFDVN
>Mature_223_residues
MRVLVIEDNSLLRHHLMVQMREMGHQVDAAADAREADYFLNEHPPDIAIVDLGLPDEDGLNLIRRWRSHQVKIPLLVLTA
REGWQDKVTVLEAGADDYVTKPFHLEEVVARMQALMRRNSGLASQVIELPPFLIDLSRRELMINEVNIRLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKMQANYPYEVITTVRGQGYRFDVN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=82.4324324324324, Blast_Score=379, Evalue=1e-107,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=36.697247706422, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.2342342342342, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=33.9285714285714, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=32.1428571428571, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=32.4200913242009, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.1310043668122, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.7777777777778, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI2367329, Length=177, Percent_Identity=31.0734463276836, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=25, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=31.1320754716981, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25702; Mature: 25702

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVIEDNSLLRHHLMVQMREMGHQVDAAADAREADYFLNEHPPDIAIVDLGLPDEDGL
CEEEEEECCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCHH
NLIRRWRSHQVKIPLLVLTAREGWQDKVTVLEAGADDYVTKPFHLEEVVARMQALMRRNS
HHHHHHHCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVIELPPFLIDLSRRELMINEVNIRLTAFEYTIIETLIRNAGKVVSKDSLMLQLYP
CHHHHHHHCCCCEEECCCCEEEEEEEEEEEEEHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKMQANYPYEVITTVRGQGYRFDVN
CCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECC
>Mature Secondary Structure
MRVLVIEDNSLLRHHLMVQMREMGHQVDAAADAREADYFLNEHPPDIAIVDLGLPDEDGL
CEEEEEECCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCHH
NLIRRWRSHQVKIPLLVLTAREGWQDKVTVLEAGADDYVTKPFHLEEVVARMQALMRRNS
HHHHHHHCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVIELPPFLIDLSRRELMINEVNIRLTAFEYTIIETLIRNAGKVVSKDSLMLQLYP
CHHHHHHHCCCCEEECCCCEEEEEEEEEEEEEHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKMQANYPYEVITTVRGQGYRFDVN
CCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA