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The map label for this gene is phoQ [H]

Identifier: 85059059

GI number: 85059059

Start: 1789447

End: 1790913

Strand: Reverse

Name: phoQ [H]

Synonym: SG1081

Alternate gene names: 85059059

Gene position: 1790913-1789447 (Counterclockwise)

Preceding gene: 85059060

Following gene: 85059058

Centisome position: 42.94

GC content: 56.99

Gene sequence:

>1467_bases
ATGACCCTATTTCCGTTACGCCACAAAAAACCGTTTTCCCTGCGCGTCAGATTCTTGCTGGCGGCAGCCTGCGTAGTTCT
GGCTCTCTCTCTGTGCTACGGCATGGTGGCCGTCATTGGCTACAGCGTCAGCTTTGATAAAACGTCATTCCGCCTGCTGC
GCGGCGAAAGTAATCTTTTTTTCAGTCTGGCGCAGTGGAAGGACAATAAGCTGTCAATCGCCGTGCCGCCGAATATCGAT
ATCAATTTTGCCGCCCTGGTGCTGATCTATGATGAAAATGGCCATATTCTCTGGCGCCAGCGCTATGTACCGGCGCTGGA
GTCGCGCTTACAGCAGGACTGGCTGACCAAGACTGGCTATTTTGAGCTCGATACCGATACGCGCACCAGTAGCGCGGTGG
TGGGGGATAATCCCAGCGCCCAGGTTCAGCTGAAAGAGTTCGACAGCAGCAACGACAATGCTCTGACCCACTCCGTGGCG
GTCAACCGCTATCCGGCTACCGGCCGCCTGCCGCCGCTGACCATTGTGGTCGTCGATACCATTCCTCATGAGCTGCAGCG
CACCGATCTGGTGTGGGAATGGTTCAGCTACGTTCTGCTTGCCAATCTGCTGCTGGTGGTGCCGCTGCTGTGGCTGGCGG
CGCACTGGAGCCTGCGCCCCATCAAGGATTTAGTTCGCCAGGTGCGCGAGCTGGAGGTGGGCGAGCGGGAACGCCTTGAC
GAGAACCCGCCGTGTGAGCTGGACATTCTGGTGCGCAACCTGAGTATCCTGCTGAATAACGAACGTCAGCGCTATCAGAA
GTACCGCTCGACCCTGTCGGATTTGACCCACAGCCTGAAAACGCCGCTGGCGGTGCTGCAGACCACGCTGCGCTCCCTGC
GTACCGATCGCGACACCAATATCGAAATGGCGGAGCCGATTATGCTGGAGCAAATCAGCCGGATTTCCCAACAGATAGGC
TATTACCTGCATCGTGCCACCGTTCACTCGGATCATAATGTGCTGAGCCGTGAACTGCATTCCGTGCCGCCGCTGCTCGA
TAGCCTGTGCTCCGCGCTCAACAAGGTGTATCAACGTAAAGGCGTTTCTCTGTCACTGGATATTTCACCGGAGTTGACGT
TTATCGGCGAGAAAAACGACTTTATGGAAGTGATGGGTAATATTTTGGACAACGCCTGCAAGTATTGCCTGGAGTTTGTC
GAAGTCAGCGCCCGCGAAAGGGAAAGCGCGCTGCATATAATTATCGAAGATGATGGCCCCGGCATCCCCGAGTCCAAACG
CACGCTCATCTTCCAGCGCGGTCAGCGCGCCGATACGCTGCGGCCCGGTCAGGGCCTGGGCCTTTCGGTGGCAGCGGAAA
TTCTTGAGCAATACGACGGCGACATCGTGATTGGCGAAAGTGCCCTAGGCGGGGCGTTGGTCGAAGTCATTTTCAAGCGG
CAGGGGCCTCAGCCCGAAGACAACTGA

Upstream 100 bases:

>100_bases
TAATGGGGCGTCTGCGGAAAAAAATGCAGGCCAATTACCCGTATGAAGTGATCACCACAGTTCGCGGTCAGGGCTACCGT
TTTGATGTTAACTAGGCTCT

Downstream 100 bases:

>100_bases
GGTCGGTCACGGGCGCTCCGTCACGTTTGACGCACCGCAGGTAAAATTATCCGGCCTGTGCGGCGGCGCTATCCGTTATA
ATTCCTCTCAATCTCCCTGC

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTLFPLRHKKPFSLRVRFLLAAACVVLALSLCYGMVAVIGYSVSFDKTSFRLLRGESNLFFSLAQWKDNKLSIAVPPNID
INFAALVLIYDENGHILWRQRYVPALESRLQQDWLTKTGYFELDTDTRTSSAVVGDNPSAQVQLKEFDSSNDNALTHSVA
VNRYPATGRLPPLTIVVVDTIPHELQRTDLVWEWFSYVLLANLLLVVPLLWLAAHWSLRPIKDLVRQVRELEVGERERLD
ENPPCELDILVRNLSILLNNERQRYQKYRSTLSDLTHSLKTPLAVLQTTLRSLRTDRDTNIEMAEPIMLEQISRISQQIG
YYLHRATVHSDHNVLSRELHSVPPLLDSLCSALNKVYQRKGVSLSLDISPELTFIGEKNDFMEVMGNILDNACKYCLEFV
EVSARERESALHIIIEDDGPGIPESKRTLIFQRGQRADTLRPGQGLGLSVAAEILEQYDGDIVIGESALGGALVEVIFKR
QGPQPEDN

Sequences:

>Translated_488_residues
MTLFPLRHKKPFSLRVRFLLAAACVVLALSLCYGMVAVIGYSVSFDKTSFRLLRGESNLFFSLAQWKDNKLSIAVPPNID
INFAALVLIYDENGHILWRQRYVPALESRLQQDWLTKTGYFELDTDTRTSSAVVGDNPSAQVQLKEFDSSNDNALTHSVA
VNRYPATGRLPPLTIVVVDTIPHELQRTDLVWEWFSYVLLANLLLVVPLLWLAAHWSLRPIKDLVRQVRELEVGERERLD
ENPPCELDILVRNLSILLNNERQRYQKYRSTLSDLTHSLKTPLAVLQTTLRSLRTDRDTNIEMAEPIMLEQISRISQQIG
YYLHRATVHSDHNVLSRELHSVPPLLDSLCSALNKVYQRKGVSLSLDISPELTFIGEKNDFMEVMGNILDNACKYCLEFV
EVSARERESALHIIIEDDGPGIPESKRTLIFQRGQRADTLRPGQGLGLSVAAEILEQYDGDIVIGESALGGALVEVIFKR
QGPQPEDN
>Mature_487_residues
TLFPLRHKKPFSLRVRFLLAAACVVLALSLCYGMVAVIGYSVSFDKTSFRLLRGESNLFFSLAQWKDNKLSIAVPPNIDI
NFAALVLIYDENGHILWRQRYVPALESRLQQDWLTKTGYFELDTDTRTSSAVVGDNPSAQVQLKEFDSSNDNALTHSVAV
NRYPATGRLPPLTIVVVDTIPHELQRTDLVWEWFSYVLLANLLLVVPLLWLAAHWSLRPIKDLVRQVRELEVGERERLDE
NPPCELDILVRNLSILLNNERQRYQKYRSTLSDLTHSLKTPLAVLQTTLRSLRTDRDTNIEMAEPIMLEQISRISQQIGY
YLHRATVHSDHNVLSRELHSVPPLLDSLCSALNKVYQRKGVSLSLDISPELTFIGEKNDFMEVMGNILDNACKYCLEFVE
VSARERESALHIIIEDDGPGIPESKRTLIFQRGQRADTLRPGQGLGLSVAAEILEQYDGDIVIGESALGGALVEVIFKRQ
GPQPEDN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=483, Percent_Identity=65.2173913043478, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=24.8175182481752, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=27.0588235294118, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=276, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=288, Percent_Identity=23.6111111111111, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=289, Percent_Identity=24.5674740484429, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55242; Mature: 55111

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFPLRHKKPFSLRVRFLLAAACVVLALSLCYGMVAVIGYSVSFDKTSFRLLRGESNLF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCEE
FSLAQWKDNKLSIAVPPNIDINFAALVLIYDENGHILWRQRYVPALESRLQQDWLTKTGY
EEEEECCCCEEEEEECCCCCCCEEEEEEEEECCCCEEEEHHCCHHHHHHHHHHHCCCCCC
FELDTDTRTSSAVVGDNPSAQVQLKEFDSSNDNALTHSVAVNRYPATGRLPPLTIVVVDT
EEECCCCCCCCEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEC
IPHELQRTDLVWEWFSYVLLANLLLVVPLLWLAAHWSLRPIKDLVRQVRELEVGERERLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCC
ENPPCELDILVRNLSILLNNERQRYQKYRSTLSDLTHSLKTPLAVLQTTLRSLRTDRDTN
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCC
IEMAEPIMLEQISRISQQIGYYLHRATVHSDHNVLSRELHSVPPLLDSLCSALNKVYQRK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GVSLSLDISPELTFIGEKNDFMEVMGNILDNACKYCLEFVEVSARERESALHIIIEDDGP
CCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GIPESKRTLIFQRGQRADTLRPGQGLGLSVAAEILEQYDGDIVIGESALGGALVEVIFKR
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
QGPQPEDN
CCCCCCCC
>Mature Secondary Structure 
TLFPLRHKKPFSLRVRFLLAAACVVLALSLCYGMVAVIGYSVSFDKTSFRLLRGESNLF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCEE
FSLAQWKDNKLSIAVPPNIDINFAALVLIYDENGHILWRQRYVPALESRLQQDWLTKTGY
EEEEECCCCEEEEEECCCCCCCEEEEEEEEECCCCEEEEHHCCHHHHHHHHHHHCCCCCC
FELDTDTRTSSAVVGDNPSAQVQLKEFDSSNDNALTHSVAVNRYPATGRLPPLTIVVVDT
EEECCCCCCCCEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEC
IPHELQRTDLVWEWFSYVLLANLLLVVPLLWLAAHWSLRPIKDLVRQVRELEVGERERLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCC
ENPPCELDILVRNLSILLNNERQRYQKYRSTLSDLTHSLKTPLAVLQTTLRSLRTDRDTN
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCC
IEMAEPIMLEQISRISQQIGYYLHRATVHSDHNVLSRELHSVPPLLDSLCSALNKVYQRK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GVSLSLDISPELTFIGEKNDFMEVMGNILDNACKYCLEFVEVSARERESALHIIIEDDGP
CCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GIPESKRTLIFQRGQRADTLRPGQGLGLSVAAEILEQYDGDIVIGESALGGALVEVIFKR
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
QGPQPEDN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA