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The map label for this gene is folK [H]

Identifier: 85058467

GI number: 85058467

Start: 846619

End: 847125

Strand: Reverse

Name: folK [H]

Synonym: SG0489

Alternate gene names: 85058467

Gene position: 847125-846619 (Counterclockwise)

Preceding gene: 85058468

Following gene: 85058466

Centisome position: 20.31

GC content: 61.14

Gene sequence:

>507_bases
ATGGAGTGCGTCTGGCTGGCTCTTGGCAGCAATCTGGCGGAACCTCTACAGCAGGTAAGCGCCGCCCTCGTGGCGCTGGC
GAGCCTGCCGCAAACCCGGTTGGTCGCCTGCTCATCCTATTATCGCAGTCGCCCGCTGGGCCCGCAGGATCAACCCGATT
TCCTTAACGCCGTCGTGGCATTGAACACAACCTTGGCACCGGAAACGCTGCTCGATCACACCCAAGCGATCGAACTGCGC
CAGGGACGTACGCGCAAGGCCGATCGCTTTGGGCCACGCACGCTGGATCTGGATATTTTGCTGTTCGGCGAGCGCATTAT
CGCTACCTCGCGTCTGACGGTACCGCATTACGACATGCACAACCGCGAGTTTATGCTCTATCCCCTCGCGGAGCTCGCCC
CGGATCTTCAGTTTCCCAACGGCGTCCCGCTGGCTGAACGTCTGCGTCAGGTGCCGCGCAACGGCCTCACCTATTGGGAT
GAGGAGCACAGTTACCACCAGGACTGA

Upstream 100 bases:

>100_bases
CCGCGCCGCCGCGGCAAAAAAATATGCTTACCACCCTTGGCGATGAGGGTCCGACTCGTTCCCGTCCGCGCCGTCGGGCG
CCCAATCGCGACAGCGCCTG

Downstream 100 bases:

>100_bases
GCGCTGCCGCCCGCACGCTGACGCCATGGCACACTAACGCCCGTGCGGCGGTCTCTGCCTTCTCTCGCCTCATGCCAGAG
GCCACGTCGCGGCCCGCCCT

Product: 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MECVWLALGSNLAEPLQQVSAALVALASLPQTRLVACSSYYRSRPLGPQDQPDFLNAVVALNTTLAPETLLDHTQAIELR
QGRTRKADRFGPRTLDLDILLFGERIIATSRLTVPHYDMHNREFMLYPLAELAPDLQFPNGVPLAERLRQVPRNGLTYWD
EEHSYHQD

Sequences:

>Translated_168_residues
MECVWLALGSNLAEPLQQVSAALVALASLPQTRLVACSSYYRSRPLGPQDQPDFLNAVVALNTTLAPETLLDHTQAIELR
QGRTRKADRFGPRTLDLDILLFGERIIATSRLTVPHYDMHNREFMLYPLAELAPDLQFPNGVPLAERLRQVPRNGLTYWD
EEHSYHQD
>Mature_168_residues
MECVWLALGSNLAEPLQQVSAALVALASLPQTRLVACSSYYRSRPLGPQDQPDFLNAVVALNTTLAPETLLDHTQAIELR
QGRTRKADRFGPRTLDLDILLFGERIIATSRLTVPHYDMHNREFMLYPLAELAPDLQFPNGVPLAERLRQVPRNGLTYWD
EEHSYHQD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=151, Percent_Identity=64.2384105960265, Blast_Score=203, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6324073, Length=166, Percent_Identity=34.3373493975904, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19021; Mature: 19021

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00622 HTH_LUXR_1 ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECVWLALGSNLAEPLQQVSAALVALASLPQTRLVACSSYYRSRPLGPQDQPDFLNAVVA
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LNTTLAPETLLDHTQAIELRQGRTRKADRFGPRTLDLDILLFGERIIATSRLTVPHYDMH
HCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEEEEEEECCHHHHCCCCCCCCCCCC
NREFMLYPLAELAPDLQFPNGVPLAERLRQVPRNGLTYWDEEHSYHQD
CCEEEEEEHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MECVWLALGSNLAEPLQQVSAALVALASLPQTRLVACSSYYRSRPLGPQDQPDFLNAVVA
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LNTTLAPETLLDHTQAIELRQGRTRKADRFGPRTLDLDILLFGERIIATSRLTVPHYDMH
HCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEEEEEEECCHHHHCCCCCCCCCCCC
NREFMLYPLAELAPDLQFPNGVPLAERLRQVPRNGLTYWDEEHSYHQD
CCEEEEEEHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]