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The map label for this gene is coaA

Identifier: 85058104

GI number: 85058104

Start: 210405

End: 211355

Strand: Reverse

Name: coaA

Synonym: SG0126

Alternate gene names: 85058104

Gene position: 211355-210405 (Counterclockwise)

Preceding gene: 85058114

Following gene: 85058093

Centisome position: 5.07

GC content: 54.36

Gene sequence:

>951_bases
ATGATTAAAGCTGTGCAATCTCCCCCCACACCATACCTGCAATTCAGCCGCAAACAGTGGGCCGCGTTGCGTAATTCCGT
GCCGCTGACGCTCACCGAAGCGGAAATCGTCAATCTCAAGGGGATAAATGAAGATCTTTCCCTTGAAGAAGTGGCAGAGA
TTTATCTGCCGCTGTCGCGTTTGCTCAATTTTTATATTAGTTCCAATCTGCGCCGCCAGGCCGTGCTGGAGCAGTTCCTT
GGCACCGACGGCCAGCGTATTCCCTATATCATCGGCATCGCCGGCAGCGTGGCGGTAGGCAAGAGCACCACGGCGCGCGT
GCTGCAGGCGCTGTTGAGCCGCTGGCCCGAACACCGCACGGTAGAGCTGGTGACGACCGACGGGTTTTTGCATCCCAACA
GCGTACTCAAGCAGCGGGATCTCATGAAGAAAAAGGGCTTTCCGGAGTCCTATGATATTCGCAGCCTGGTCAATTTCGTC
TCGAAAGTGAAATCAGGCACGCCGCGCGTGACGGCCCCGGTCTATTCCCACTTGATTTACGACGTTGTGCCCGACGAACA
GAAAGTCATTTCCCAACCGGACATTCTGATATTGGAAGGATTAAACGTGTTGCAAAGCGGCAGCGATTATAACCATGATC
CCCACCACGTGTTCGTCTCCGACTTTGTCGATTTTTCCATCTATGTCGATGCGCCTGAGACGCTGCTGCAGAGCTGGTAT
ATCAATCGTTTTCTAAAATTTCGCCAGGGAGCGTTTTCCGATCCCGACTCCTATTTCCACCATTATTCCCAGCTTTCCGA
GCAAGAGGCGGTCGCCATCGCCAGCCAGCTGTGGAGCGAAATCAACGGCCGCAACCTGCAGCAAAACATTCTGCCTACCC
GCGAGCGCGCGAGTCTTATCCTTGGCAAAAGCGCCAATCATGCGGTGGAGAGAGTCCGGCTGCGCAAATAG

Upstream 100 bases:

>100_bases
TCTACGCTGGGTACGAGGCTGTCTATACTATGCAGCTTGTTTTCTTTCCGGGTTAGCGTCCTGCGCCCTGAATAGACTGT
GCAACGGGCTGGCTCACGTT

Downstream 100 bases:

>100_bases
GGTCGTGCCGCTACTGCGGCAGACCCACCTTACTCCTCCTCCGGCATCGCGTCAGCGCGAATCTGCACGCCGCCGCAGAT
CCCTATCCATGCCCAATGCG

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIKAVQSPPTPYLQFSRKQWAALRNSVPLTLTEAEIVNLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFL
GTDGQRIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRTVELVTTDGFLHPNSVLKQRDLMKKKGFPESYDIRSLVNFV
SKVKSGTPRVTAPVYSHLIYDVVPDEQKVISQPDILILEGLNVLQSGSDYNHDPHHVFVSDFVDFSIYVDAPETLLQSWY
INRFLKFRQGAFSDPDSYFHHYSQLSEQEAVAIASQLWSEINGRNLQQNILPTRERASLILGKSANHAVERVRLRK

Sequences:

>Translated_316_residues
MIKAVQSPPTPYLQFSRKQWAALRNSVPLTLTEAEIVNLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFL
GTDGQRIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRTVELVTTDGFLHPNSVLKQRDLMKKKGFPESYDIRSLVNFV
SKVKSGTPRVTAPVYSHLIYDVVPDEQKVISQPDILILEGLNVLQSGSDYNHDPHHVFVSDFVDFSIYVDAPETLLQSWY
INRFLKFRQGAFSDPDSYFHHYSQLSEQEAVAIASQLWSEINGRNLQQNILPTRERASLILGKSANHAVERVRLRK
>Mature_316_residues
MIKAVQSPPTPYLQFSRKQWAALRNSVPLTLTEAEIVNLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFL
GTDGQRIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRTVELVTTDGFLHPNSVLKQRDLMKKKGFPESYDIRSLVNFV
SKVKSGTPRVTAPVYSHLIYDVVPDEQKVISQPDILILEGLNVLQSGSDYNHDPHHVFVSDFVDFSIYVDAPETLLQSWY
INRFLKFRQGAFSDPDSYFHHYSQLSEQEAVAIASQLWSEINGRNLQQNILPTRERASLILGKSANHAVERVRLRK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=311, Percent_Identity=82.3151125401929, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI1789296, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_SODGM (Q2NWS4)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_453806.1
- ProteinModelPortal:   Q2NWS4
- SMR:   Q2NWS4
- STRING:   Q2NWS4
- GeneID:   3867960
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0126
- NMPDR:   fig|343509.6.peg.261
- eggNOG:   COG1072
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- PhylomeDB:   Q2NWS4
- ProtClustDB:   PRK05439
- BioCyc:   SGLO343509:SG0126-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 35857; Mature: 35857

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKAVQSPPTPYLQFSRKQWAALRNSVPLTLTEAEIVNLKGINEDLSLEEVAEIYLPLSR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHEEEECCCCCCCCHHHHHHHHHHHHH
LLNFYISSNLRRQAVLEQFLGTDGQRIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRT
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
VELVTTDGFLHPNSVLKQRDLMKKKGFPESYDIRSLVNFVSKVKSGTPRVTAPVYSHLIY
EEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHH
DVVPDEQKVISQPDILILEGLNVLQSGSDYNHDPHHVFVSDFVDFSIYVDAPETLLQSWY
HCCCCHHHHHCCCCEEEECCCHHHHCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHH
INRFLKFRQGAFSDPDSYFHHYSQLSEQEAVAIASQLWSEINGRNLQQNILPTRERASLI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHEE
LGKSANHAVERVRLRK
ECCCHHHHHHHHHCCC
>Mature Secondary Structure
MIKAVQSPPTPYLQFSRKQWAALRNSVPLTLTEAEIVNLKGINEDLSLEEVAEIYLPLSR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHEEEECCCCCCCCHHHHHHHHHHHHH
LLNFYISSNLRRQAVLEQFLGTDGQRIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRT
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
VELVTTDGFLHPNSVLKQRDLMKKKGFPESYDIRSLVNFVSKVKSGTPRVTAPVYSHLIY
EEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHH
DVVPDEQKVISQPDILILEGLNVLQSGSDYNHDPHHVFVSDFVDFSIYVDAPETLLQSWY
HCCCCHHHHHCCCCEEEECCCHHHHCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHH
INRFLKFRQGAFSDPDSYFHHYSQLSEQEAVAIASQLWSEINGRNLQQNILPTRERASLI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHEE
LGKSANHAVERVRLRK
ECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA