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The map label for this gene is trpC [H]

Identifier: 84625592

GI number: 84625592

Start: 4433538

End: 4434335

Strand: Reverse

Name: trpC [H]

Synonym: XOO_3935

Alternate gene names: 84625592

Gene position: 4434335-4433538 (Counterclockwise)

Preceding gene: 84625593

Following gene: 84625591

Centisome position: 89.76

GC content: 64.29

Gene sequence:

>798_bases
ATGAGCGACATCCTCAACACCATTCTTGCCCGCAAGGCCGACGAAGTCGCCGAGCGCAGTGCGCGCGTGCCGCTGGCCGA
GTTGATCGCGCGCAGCGCCGACCTGCCGCTCACGCGCGGTTTTGCGGCTGCCATGCAGGCCAGCATCGCCGCCGGCGATC
CGGCCGTGATTGCCGAAGTGAAGAAGGCCAGCCCGTCCAAGGGCGTGATCCGGCCCGACTTCCATCCGGCCGATATCGCG
GTCAGCTATGAGTTCGGCGGCGCGACGTGCCTGTCGGTGCTCACCGATGTGGATTTCTTCCAGGGATCCGATGCCTATCT
ACGGCAGGCGCGCGACGCCTGCACCCTGCCGGTGCTGCGCAAGGATTTCACCGTCGACCCGTATCAGGTCTATGAAGCCC
GCGTGCTCGGTGCCGACTGCATCCTGTTGATCGTCTCCGCATTGAAAGATGCCCAATTGGCCGATTTGTCGGGGCTGGCC
ATGCAGCTGGGCCTGGACGTGCTGGTGGAAGTGCACGATGTCGACGAGCTCGAGCGTGCGGTGCAGGTGCCGGTGCCGTT
GATCGGCATCAATAATCGCAACCTGCGCACTTTCGAGGTCACGCTGCAGACCACCCTGGACATGCGCGCCGCGGTGCCGC
GCGACCGCGTGCTGGTTACCGAAAGCGGCATCGTCACCCAGGCCGATGTGCAACTGATGCGCAGCAACGATGTGAACGCG
TTTCTGGTTGGCGAGACCTTCATGCGCGCGGCCGAACCCGGCGAGTCACTGCGTCAGCTATTCTTCGCGCATGACTGA

Upstream 100 bases:

>100_bases
CCGGCATCCGCACAGTGACGCTGGCATGCTGCGCGGCATGCAGCTGCCCTCCAGTGCGGTTATCTTGACCGATAATGCCC
GACCGCCAGGACCCAATACG

Downstream 100 bases:

>100_bases
GTCGTATCCCGCACCGCGCGAAGACGCACCGCTGGTGGTGTTCGACTTCGACCACACCCTGTACGACGGCGATTCCGGCA
GTCATCTGTTCGCCTGGCTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFHPADIA
VSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALKDAQLADLSGLA
MQLGLDVLVEVHDVDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRAAVPRDRVLVTESGIVTQADVQLMRSNDVNA
FLVGETFMRAAEPGESLRQLFFAHD

Sequences:

>Translated_265_residues
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFHPADIA
VSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALKDAQLADLSGLA
MQLGLDVLVEVHDVDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRAAVPRDRVLVTESGIVTQADVQLMRSNDVNA
FLVGETFMRAAEPGESLRQLFFAHD
>Mature_264_residues
SDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFHPADIAV
SYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALKDAQLADLSGLAM
QLGLDVLVEVHDVDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRAAVPRDRVLVTESGIVTQADVQLMRSNDVNAF
LVGETFMRAAEPGESLRQLFFAHD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=248, Percent_Identity=41.1290322580645, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=272, Percent_Identity=35.2941176470588, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28724; Mature: 28593

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEV
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVIRPDFHPADIAVSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLR
HHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
KDFTVDPYQVYEARVLGADCILLIVSALKDAQLADLSGLAMQLGLDVLVEVHDVDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEECCHHHHHHH
VQVPVPLIGINNRNLRTFEVTLQTTLDMRAAVPRDRVLVTESGIVTQADVQLMRSNDVNA
HHCCCEEEECCCCCEEEEEEEEEEHHHHHHCCCCCEEEEECCCCEEHHHHHHHHCCCCCE
FLVGETFMRAAEPGESLRQLFFAHD
EEECHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVIRPDFHPADIAVSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLR
HHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
KDFTVDPYQVYEARVLGADCILLIVSALKDAQLADLSGLAMQLGLDVLVEVHDVDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEECCHHHHHHH
VQVPVPLIGINNRNLRTFEVTLQTTLDMRAAVPRDRVLVTESGIVTQADVQLMRSNDVNA
HHCCCEEEECCCCCEEEEEEEEEEHHHHHHCCCCCEEEEECCCCEEHHHHHHHHCCCCCE
FLVGETFMRAAEPGESLRQLFFAHD
EEECHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]