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The map label for this gene is folC [H]

Identifier: 84625132

GI number: 84625132

Start: 3935299

End: 3936597

Strand: Reverse

Name: folC [H]

Synonym: XOO_3475

Alternate gene names: 84625132

Gene position: 3936597-3935299 (Counterclockwise)

Preceding gene: 84625133

Following gene: 84625131

Centisome position: 79.68

GC content: 67.28

Gene sequence:

>1299_bases
ATGACCACCCCCACCACACTCTCCGAGTGGCTCGCCTACATCGAGCAGCAACACCCCAGCAGTATCGCGATGGGATTGGA
GCGCGTGCGCGAGGTGGCTGCGCGCCTGCAGATCGCAGCGCCAGCCAAGCATGCCATCGTCGTGGGCGGGACCAATGGCA
AGGGCTCGACCGTGGCCTTTATCGAGGCGATCGGGCGTGCTGCCGGCTGGAAGATCGGTGCCTACACCTCGCCGCATCTG
CTGCGCTACAACGAGCGCGTGCGTATCGACGGCGAGGAGGCCAGCGACGCGCAGCTGGTCGATGCGTTTGCTGCGGTAGA
GGCAGCGCGCGGCGACACCGCGCTGACCTATTTCGAATTCGGCACGTTGGCGGCCTTGTGGCTGTTCCAGAGCGCCGCGC
TGGATCTGACGGTGCTGGAAATCGGCCTGGGCGGGCGCCTGGATGCGGTCAACATCGTCGATGCGGATGTGGCGGTGATC
ACCACCGTCGACATCGACCATACCGATTGGCTGGGCGAAGACCGCGAGGCCATCGGCACCGAGAAGGCCGGCATCATGCG
CGCCTGGAAGCCGGTGGTGCTGGGCGAGATCGACCCGCCATCCAGCGTGTTGCGGCGCGCCTACCAGCTGGGTGCCAATG
CGATCCGTGCCGGCAGCGATTATTTCTTCGAGCCGATTGAGGTGCAGCACCCCGAAAACCCGCAATCCGACGCGCCGCAA
TGGCGCTGGCGCGATGTGGCAGTGACATTGGAATTGCCGATGCCGGCATTGCACGCGCCGGTACAGCTGGCCAACGCAGC
CGCTGCGATCGCCGCATTGCAGGCGTTGCCGGTGGAGGTGCCCGCTGCAGCTTGGGTGCAGGGCATCGGCAACGCGCAAG
TGGCCGGGCGATTGCAGCGCCTTGCGGTCGATGGCCTTCAGGTGTTGCTGGATGTCGGCCACAACCCACAGGCCGCACGC
GCGCTGGCCGCCGCGCTCGGTGCGCAGGCGCACGCCGGCAGCACCTACGCGATCTACGCTGCTCTTGCCGACAAGGATGT
CGTGGGCGTGGTGGAGGCAGTCGCTGCGCAAATCGACCACTGGGCATTGGCGGGGCTGGAGGGCGCGCGTGGACAATCGG
CGCAGGCGCTGCACGCACGCCTGCAAGGGACTGCCGCCGCGCAGGCGCTGTGTCACCGCGACGTTGCCAGCGCAGTGGAG
GCGGTCCTGGCCACAGCCAGCCCCGGCGACCGCGTGCTGGTGTTCGGCTCGTTTCACACCGTGGCCGACGCGCTTAGCGC
ACTTCATTCAGCCTGTTGA

Upstream 100 bases:

>100_bases
CGCCATCTGCCCAGGCAATGCATCCAGTGTTGCGACCGTTGGTAGGCCACGCTGGCGTCACGCGCGCGATAATCTCGCTC
GCACGGCATCAGGTAACCCC

Downstream 100 bases:

>100_bases
GGTCGTCGAGGTGGCGCCGGCCTTATAATCGCCGCGGCACCCCGCCACGCCGCCTCTCGTCTCTTCCGTGGATACTGCTC
TGAAACAGCGACTGATTGGC

Product: folylpolyglutamate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTTPTTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAFIEAIGRAAGWKIGAYTSPHL
LRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVI
TTVDIDHTDWLGEDREAIGTEKAGIMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQ
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQRLAVDGLQVLLDVGHNPQAAR
ALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDHWALAGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVE
AVLATASPGDRVLVFGSFHTVADALSALHSAC

Sequences:

>Translated_432_residues
MTTPTTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAFIEAIGRAAGWKIGAYTSPHL
LRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVI
TTVDIDHTDWLGEDREAIGTEKAGIMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQ
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQRLAVDGLQVLLDVGHNPQAAR
ALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDHWALAGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVE
AVLATASPGDRVLVFGSFHTVADALSALHSAC
>Mature_431_residues
TTPTTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAFIEAIGRAAGWKIGAYTSPHLL
RYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVIT
TVDIDHTDWLGEDREAIGTEKAGIMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQW
RWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQRLAVDGLQVLLDVGHNPQAARA
LAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDHWALAGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVEA
VLATASPGDRVLVFGSFHTVADALSALHSAC

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=177, Percent_Identity=37.2881355932203, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI66932990, Length=177, Percent_Identity=37.2881355932203, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1788654, Length=425, Percent_Identity=44.7058823529412, Blast_Score=324, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17553148, Length=177, Percent_Identity=36.1581920903955, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71984923, Length=177, Percent_Identity=36.1581920903955, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553150, Length=177, Percent_Identity=36.1581920903955, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323760, Length=370, Percent_Identity=24.0540540540541, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324815, Length=209, Percent_Identity=33.4928229665072, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24641571, Length=150, Percent_Identity=37.3333333333333, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24581568, Length=145, Percent_Identity=37.2413793103448, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 45304; Mature: 45172

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAF
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCHHHH
IEAIGRAAGWKIGAYTSPHLLRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEF
HHHHHHHCCCEECCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHH
GTLAALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVITTVDIDHTDWLGEDREAIGT
HHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCEEEEEEEECCCCCCCCCCHHHHCC
EKAGIMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQ
CHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHEECCCCCCCCCEEECCCCCCCCCCCC
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQR
CEEEEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHH
LAVDGLQVLLDVGHNPQAARALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
WALAGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVEAVLATASPGDRVLVFGSFHT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
VADALSALHSAC
HHHHHHHHHHCC
>Mature Secondary Structure 
TTPTTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAF
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCHHHH
IEAIGRAAGWKIGAYTSPHLLRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEF
HHHHHHHCCCEECCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHH
GTLAALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVITTVDIDHTDWLGEDREAIGT
HHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCEEEEEEEECCCCCCCCCCHHHHCC
EKAGIMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQ
CHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHEECCCCCCCCCEEECCCCCCCCCCCC
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQR
CEEEEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHH
LAVDGLQVLLDVGHNPQAARALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
WALAGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVEAVLATASPGDRVLVFGSFHT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
VADALSALHSAC
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]