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The map label for this gene is cobC [H]

Identifier: 84625133

GI number: 84625133

Start: 3937570

End: 3938214

Strand: Reverse

Name: cobC [H]

Synonym: XOO_3476

Alternate gene names: 84625133

Gene position: 3938214-3937570 (Counterclockwise)

Preceding gene: 84625134

Following gene: 84625132

Centisome position: 79.72

GC content: 66.98

Gene sequence:

>645_bases
ATGCGCATCCTGCTTGCTCGTCACGGCGAGACGCCGTGGAACGCCGAAGGCCGTTACCAGGGCCAGATCGATATTCCGCT
GTCGCCGGTTGGCGAAGGTCAGGCGCGCGCGTTGGGCGAACGGCTACACGCGCTGCAGATCGACCGCGCAGTGGCGTCGC
CGCTGTCGCGTGCGCAGGCCACTGCCAAGGCTGCGCTGGGCGCGTCGCGCGAGGCGCTGTTGCAGACCGATGCCGATCTG
CAGGAAATTGCGCACGGCGAGTGGGAGGGCCTGCTGGCCAGCGAGATCAACGACAAGGATCCAGCACGTTTGCGCGCCTG
GCGCGAAGAGCCCGACACCGTGCTGATGCCGGGCGGCGAATCGTTGCGTCAGGTGCTGGACCGCAGCTGGCGCGGCCTGG
TGCGCGCCGCCGATGGACTGGGCGCCGACGACACCTTGCTGGTGGTCGCACACGATGCGGTCAATCGCGTGATCCTGTGC
AATATCCTGGGGCTGCCGCTGTCCAAGCTGTGGAGCTTCCGCCAGGCCCCGACCACGCTCAATCTGCTCGAAGGCGATGA
CGTCGAGCACCTCGAAGTGGTCCGCCTCAACGACTGCGCCCACCACACACCGTTCTTTGGTGAGGCCAAGCATCGGGCGT
TGTAG

Upstream 100 bases:

>100_bases
GTGCGCTGACGCGGGCGGCCGGCGGGGCGGCGTCAGGGGTATGATGCGGTCCGGTTTCGCTGCGGCGAGCCGGTCCCTCC
CCCCAAGGAACTCCCAGCGC

Downstream 100 bases:

>100_bases
CCTCTGGCAACCTCAGCGCAGGTCTACCAGGACGGAGACGAGTCATCATAGGCATGTTGCGAGACACAGGACGTCTGCAG
CGCGTCTGCCTCTTTCTGGC

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRILLARHGETPWNAEGRYQGQIDIPLSPVGEGQARALGERLHALQIDRAVASPLSRAQATAKAALGASREALLQTDADL
QEIAHGEWEGLLASEINDKDPARLRAWREEPDTVLMPGGESLRQVLDRSWRGLVRAADGLGADDTLLVVAHDAVNRVILC
NILGLPLSKLWSFRQAPTTLNLLEGDDVEHLEVVRLNDCAHHTPFFGEAKHRAL

Sequences:

>Translated_214_residues
MRILLARHGETPWNAEGRYQGQIDIPLSPVGEGQARALGERLHALQIDRAVASPLSRAQATAKAALGASREALLQTDADL
QEIAHGEWEGLLASEINDKDPARLRAWREEPDTVLMPGGESLRQVLDRSWRGLVRAADGLGADDTLLVVAHDAVNRVILC
NILGLPLSKLWSFRQAPTTLNLLEGDDVEHLEVVRLNDCAHHTPFFGEAKHRAL
>Mature_214_residues
MRILLARHGETPWNAEGRYQGQIDIPLSPVGEGQARALGERLHALQIDRAVASPLSRAQATAKAALGASREALLQTDADL
QEIAHGEWEGLLASEINDKDPARLRAWREEPDTVLMPGGESLRQVLDRSWRGLVRAADGLGADDTLLVVAHDAVNRVILC
NILGLPLSKLWSFRQAPTTLNLLEGDDVEHLEVVRLNDCAHHTPFFGEAKHRAL

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=174, Percent_Identity=31.0344827586207, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790856, Length=170, Percent_Identity=32.9411764705882, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322896, Length=191, Percent_Identity=29.8429319371728, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23470; Mature: 23470

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLARHGETPWNAEGRYQGQIDIPLSPVGEGQARALGERLHALQIDRAVASPLSRAQA
CEEEEEECCCCCCCCCCEECCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAKAALGASREALLQTDADLQEIAHGEWEGLLASEINDKDPARLRAWREEPDTVLMPGGE
HHHHHHCCCHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCH
SLRQVLDRSWRGLVRAADGLGADDTLLVVAHDAVNRVILCNILGLPLSKLWSFRQAPTTL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCEEEEHHHCCCHHHHHHHHCCCCEE
NLLEGDDVEHLEVVRLNDCAHHTPFFGEAKHRAL
EEECCCCCCEEEEEEECCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MRILLARHGETPWNAEGRYQGQIDIPLSPVGEGQARALGERLHALQIDRAVASPLSRAQA
CEEEEEECCCCCCCCCCEECCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAKAALGASREALLQTDADLQEIAHGEWEGLLASEINDKDPARLRAWREEPDTVLMPGGE
HHHHHHCCCHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCH
SLRQVLDRSWRGLVRAADGLGADDTLLVVAHDAVNRVILCNILGLPLSKLWSFRQAPTTL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCEEEEHHHCCCHHHHHHHHCCCCEE
NLLEGDDVEHLEVVRLNDCAHHTPFFGEAKHRAL
EEECCCCCCEEEEEEECCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]