Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 84624053

GI number: 84624053

Start: 2661056

End: 2662261

Strand: Direct

Name: fadA [H]

Synonym: XOO_2396

Alternate gene names: 84624053

Gene position: 2661056-2662261 (Clockwise)

Preceding gene: 84624052

Following gene: 84624054

Centisome position: 53.87

GC content: 65.84

Gene sequence:

>1206_bases
ATGAGCAAGCAGATTCAAGACGCCTATATCGTTGCCGCCACGCGTACGCCGGTGGGCAAGGCGCCGAAAGGCGTGTTCCG
CAACACCCGTCCCGACGACATGCTGGCGCACGTGCTGCGCGCGGTGGTGGCGCAGGCGCCGGGCATCGACACCTCGCGCA
TCGACGACGCCATCATCGGCTGCGCCATGCCCGAGGGCGAGCAAGGCATGAACGTGGCGCGTATCGGCGTGCTGCTGGCA
GGCCTGCCGAATTCGGTGGCCGGTCAGACCATCAACCGGTTCTGTTCGTCCGGCATCCAGGCCATCGCCATGGCGGCCGA
CCAGATCCGTCTGGGCAATGCCGATCTGATGCTGGCCGGCGGCACCGAGTCGATGTCGATGGTGCCGATGATGGGCAACA
AGGTGGCGATGTCGCCGAGCGTGTTCGCCGACGACCATGTGGCCATTGCCTATGGCATGGGCATCACCGCCGAGAAGGTC
GCAGAAGAATGGAAGGTGTCGCGCGAAGATCAGGATGCCTTCGCACTGGCCTCGCATCAGAAGGCCATCGCCGCGATTGC
CGCCGGCGAGTTCCGCGACGAAATCACCCCGTACGAAATTCACTCGCATCAGCCCGATCTGGCAGGCAACGTCATCGCGC
TGCGCAAGCACCTGGTCGATACCGACGAAGGCCCGCGTCCGGATAGCTCGCTTGAAGGCCTGGCCAAGCTGCGCCCGGTG
TTCCGCAACGGCCAGTTCGGCGGCAGCGTCACCGCCGGTAACTCCTCGCAGATGAGCGATGGCGCCGGCGCGGTGCTGCT
GGCGTCGGAACAGGCGATCAAGGATTACGGCCTGACCCCGCTGGCGCGTTTCGTCAGCTTCTCGGTCGCCGGTGTACGCC
CGGAAGTGATGGGCATCGGCCCGATCGCTGCGATTCCCAAGGCGCTCAAGCAGGCCGGCATGACCAAGGGCCAGATCGAC
TGGATCGAGCTCAACGAAGCCTTCGCCGCGCAGGCACTGGCGGTGATCCGCGATAGCGAGCTGGATCCGTCCAAGGTCAA
TCCGCTGGGCGGCGCCATTGCGCTCGGCCATCCGCTGGGCGCCACCGGCGCGATCCGTGCTGCCACGCTGGTGCATGGCC
TGCGCCGTCTGCAGCAGAAGTACGGCATGGTCACCATGTGCATCGGCACCGGCATGGGCGCGGCTGGCATCATCGAAGCG
CTGTAA

Upstream 100 bases:

>100_bases
CACCAAATTTATCCGCCGGGTTGGACCATTCGGACATCGGGATTCGCTTTGACGAATCCCAAATCTCGAATCCCGAATCC
CGGCCATCGGAGATAGCCAA

Downstream 100 bases:

>100_bases
GGACCAACGCCCGAGCCACCCTGGCGGGTAGATCAGGATGCTACAGCGGCCGGAGAGCCATCGCTCGCCGGCCGTTTTCC
ATGCGGATGAATGGCGTCGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKQIQDAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKHLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGMTKGQID
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRLQQKYGMVTMCIGTGMGAAGIIEA
L

Sequences:

>Translated_401_residues
MSKQIQDAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKHLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGMTKGQID
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRLQQKYGMVTMCIGTGMGAAGIIEA
L
>Mature_400_residues
SKQIQDAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLAG
LPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVA
EEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKHLVDTDEGPRPDSSLEGLAKLRPVF
RNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGMTKGQIDW
IELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRLQQKYGMVTMCIGTGMGAAGIIEAL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.0632911392405, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI167614485, Length=409, Percent_Identity=40.5867970660147, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=38.5572139303483, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=35.7843137254902, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=31.1659192825112, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI194353979, Length=247, Percent_Identity=36.0323886639676, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=44.1747572815534, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=43.25, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=41.1330049261084, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=41.4634146341463, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1788683, Length=443, Percent_Identity=31.8284424379233, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=38.6699507389163, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=405, Percent_Identity=34.5679012345679, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=32.512315270936, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=28.4424379232506, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=30.2267002518892, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=41.3366336633663, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=36.6504854368932, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24655093, Length=407, Percent_Identity=39.8034398034398, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17648125, Length=418, Percent_Identity=39.2344497607655, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.2298288508557, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.447963800905, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41828; Mature: 41696

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQIQDAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCCCEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKHLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGMTKGQIDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRLQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHCC
>Mature Secondary Structure 
SKQIQDAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCCEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKHLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGMTKGQIDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRLQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]