Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 84622826

GI number: 84622826

Start: 1278122

End: 1279510

Strand: Direct

Name: gabP [H]

Synonym: XOO_1169

Alternate gene names: 84622826

Gene position: 1278122-1279510 (Clockwise)

Preceding gene: 84622825

Following gene: 84622828

Centisome position: 25.87

GC content: 66.38

Gene sequence:

>1389_bases
ATGCCGCTTCCGACCGACCCCGTTGCTGAGACCGCTGCGTCCGCCGCACCTGTACTGCGTCATGCGCTGAAGCCGCGGCA
ATTGATGATGATGGGGCTGGGCACGGCGATCGGCGCCGGGCTGTTTCTGGGTTCGGGCGTGGGCATCCATGCGGCCGGGC
CGGCCGCGCTGGTGTCCTACCTGATCGCCGGTGGCCTGGTGATCATCGTGATGAACGCGCTGGGCGAGATGGCGGCCGCC
AAGCCGACCAGCGGCGCATTCTCGGTCTACGCGGCCGATGCGATGGGTCCGACCGCCGGGGCAACAGTGGGCTGGTTGTG
GTGGCTGCAGATCGTGGTGGTGATCGCGGCCGAAGCAGTCGGTGCGGCTGGGCTGCTGGCGACGGTCTGGCCGGCGTTGC
CGGTGCCGCTGCTGGCGTTGCTGTTCATGGCCACGTTCACTGCGATCAATCTGCTCGGCGTGCGCAACTTCGGCGAGTTC
GAATTCTGGTTCGCCATTCTCAAGGTCCTGGCGATCGTGGTGTTTTTGCTGATCGGCATTGCCTTGCTGGCCGGCTGGTT
GCCTGGTGTCACTTCACCGGGGCTGTCCAATTTCACCCAGAACGGCGGGTTTGCGCCGAAGGGGCTGGCCGGTATCGGCT
CGGCGTTGCTGGTGGTGGTGTTCGCTTTCGGCGGCACCGAGATCGTGGCGGTGGCCGCAGCGGAAACCGCCGACCCGGGC
CGCAGCCTGGCGCGTACCATCCGCACCGTGGCCGGGCGCATCCTGGTGTTCTATATCGGTTCGATCAGCGTGATCGTGGC
GGTGGTGCCGTGGACCAGCACGGCGCTCAGCTCGCCGTTCGCTGCCGTGCTGCAAGTGGCACGCATTCCCGGTGCCGCCA
CGGCAATCACCCTGGTGGCGGTGGTGGCGCTGCTGTCGGCGCTCAATGCCAATCTGTATGGCGCATCGCGGATGATCTTC
TCGCTGGCACAGCGCGGCGAAGCGCCGCGGGTGCTGGCCAGGACCAGTAGCGAGCAGGTGCCGCTGGTGGCGGTGATCGC
CAGTGTGTTGTTCGGCTTCGCTGCCGCCGCGTTGGAGTTGCTGTATCCGAACAAGGTGTTGCCGATGCTGCTCAACATCG
TCGGCGCCACCTGCCTGCTGGTGTGGACGATCTCGCTGGTGTCGCAACTGATCTTGCGCGCCCGCGCCGACCGCGCCGGT
CTCGCGTTGCCGTTCCGCATGCGCGGCTTTCCGTTTCTGACGGTGCTGGCGCTGGCGATCCTGGCGGTGATCTTCGGATT
GTTGGCCTATTCGGCCGACACGCGCGCGCAGTTCCTGTCGATGGTCACTCTGACCGCCGTCATCGCAGTGGTCAGCGAAG
TTGCGCGACGCTTCCGTTCGCGGATGTAA

Upstream 100 bases:

>100_bases
TAGCCGCTCTTGGCCACTCCTTCTCCAGGCTGGCGTCAAGAGGCGCGGCAGGCGCCGCGACGCGGTATCGTGGCGCGATT
CACGTCATTCAAGCCTGTCC

Downstream 100 bases:

>100_bases
CCGATGGGGGCCGCGTCAGTGCGCTGGCGCGTCGTGTCCAATCACGGACGTATCAGCTACTACATGCGCGCGCCGCGCTG
AGGACCGATGATCAACCGGG

Product: amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPLPTDPVAETAASAAPVLRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAALVSYLIAGGLVIIVMNALGEMAAA
KPTSGAFSVYAADAMGPTAGATVGWLWWLQIVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGIALLAGWLPGVTSPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAGRILVFYIGSISVIVAVVPWTSTALSSPFAAVLQVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRVLARTSSEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGFPFLTVLALAILAVIFGLLAYSADTRAQFLSMVTLTAVIAVVSEVARRFRSRM

Sequences:

>Translated_462_residues
MPLPTDPVAETAASAAPVLRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAALVSYLIAGGLVIIVMNALGEMAAA
KPTSGAFSVYAADAMGPTAGATVGWLWWLQIVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGIALLAGWLPGVTSPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAGRILVFYIGSISVIVAVVPWTSTALSSPFAAVLQVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRVLARTSSEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGFPFLTVLALAILAVIFGLLAYSADTRAQFLSMVTLTAVIAVVSEVARRFRSRM
>Mature_461_residues
PLPTDPVAETAASAAPVLRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAALVSYLIAGGLVIIVMNALGEMAAAK
PTSGAFSVYAADAMGPTAGATVGWLWWLQIVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFE
FWFAILKVLAIVVFLLIGIALLAGWLPGVTSPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPGR
SLARTIRTVAGRILVFYIGSISVIVAVVPWTSTALSSPFAAVLQVARIPGAATAITLVAVVALLSALNANLYGASRMIFS
LAQRGEAPRVLARTSSEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGL
ALPFRMRGFPFLTVLALAILAVIFGLLAYSADTRAQFLSMVTLTAVIAVVSEVARRFRSRM

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=405, Percent_Identity=27.6543209876543, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507047, Length=432, Percent_Identity=24.0740740740741, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI114326544, Length=422, Percent_Identity=23.696682464455, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=422, Percent_Identity=23.696682464455, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=23.9782016348774, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258645169, Length=422, Percent_Identity=22.2748815165877, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614005, Length=423, Percent_Identity=21.9858156028369, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789017, Length=420, Percent_Identity=38.8095238095238, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1786602, Length=421, Percent_Identity=36.104513064133, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786302, Length=386, Percent_Identity=36.5284974093264, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI87081708, Length=435, Percent_Identity=36.551724137931, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788480, Length=435, Percent_Identity=34.9425287356322, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1790653, Length=437, Percent_Identity=32.7231121281465, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI48994972, Length=447, Percent_Identity=33.5570469798658, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=34.3283582089552, Blast_Score=219, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17532491, Length=413, Percent_Identity=25.181598062954, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=32.7272727272727, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6324061, Length=456, Percent_Identity=30.4824561403509, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=31.1546840958606, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=411, Percent_Identity=30.4136253041363, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=439, Percent_Identity=28.9293849658314, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=376, Percent_Identity=31.1170212765957, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=28.0871670702179, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=442, Percent_Identity=29.185520361991, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=402, Percent_Identity=27.363184079602, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=412, Percent_Identity=28.6407766990291, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324990, Length=411, Percent_Identity=28.4671532846715, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=416, Percent_Identity=27.4038461538462, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=408, Percent_Identity=26.7156862745098, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320251, Length=409, Percent_Identity=26.6503667481663, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=349, Percent_Identity=29.512893982808, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=28.463476070529, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=24.2562929061785, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=23.6111111111111, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668806, Length=425, Percent_Identity=24.7058823529412, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356285, Length=425, Percent_Identity=24.7058823529412, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668802, Length=425, Percent_Identity=24.7058823529412, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=23.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=23.3333333333333, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47680; Mature: 47548

Theoretical pI: Translated: 10.99; Mature: 10.99

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTDPVAETAASAAPVLRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAALVSY
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGGLVIIVMNALGEMAAAKPTSGAFSVYAADAMGPTAGATVGWLWWLQIVVVIAAEAV
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVTSPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAGRILVFYIGSISVIVAVVPWTSTALSSPFAAVLQVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRVLARTSSEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGFPFLTVLALAI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHH
LAVIFGLLAYSADTRAQFLSMVTLTAVIAVVSEVARRFRSRM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLPTDPVAETAASAAPVLRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAALVSY
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGGLVIIVMNALGEMAAAKPTSGAFSVYAADAMGPTAGATVGWLWWLQIVVVIAAEAV
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVTSPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAGRILVFYIGSISVIVAVVPWTSTALSSPFAAVLQVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRVLARTSSEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGFPFLTVLALAI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHH
LAVIFGLLAYSADTRAQFLSMVTLTAVIAVVSEVARRFRSRM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]