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The map label for this gene is pepP [H]

Identifier: 84622686

GI number: 84622686

Start: 1123870

End: 1125210

Strand: Direct

Name: pepP [H]

Synonym: XOO_1029

Alternate gene names: 84622686

Gene position: 1123870-1125210 (Clockwise)

Preceding gene: 84622685

Following gene: 84622698

Centisome position: 22.75

GC content: 65.85

Gene sequence:

>1341_bases
ATGAAAAAGCTCACCGGGATCGGCGCGGCCGAGTACGCGCGCCGGCGCAAGCAGCTGATGCAGATGGCTGGCGAGCAGGC
GATTCTGATTTTGCCGGCCGGGCCCGAGCGGGTGCGCAGCCACGATACGCATTACCCGTACCGGCAGGATTCGGATTTCT
GGTATCTGAGCGGGTTTCCGGAGCCTGACGCAGTGCTGGTGCTGGTGCCCGGGCGCAAGCATGGCGAAGCGATTCTGTTC
TGCCGCGAGCGCGACACCGAGCGCGAAGCCTGGGATGGCCCGCGCGAAGGTCAGGAAGGCGCGGTGGAGCGCTACGGCAT
GGACGACGCGTACCCCATCGACGATGTCGACGAGATCCTGCCCGGCCTGCTGGAAGGGCGCAGCCGGGTGTACTACCACT
TCGGGCGCGACGTCGATTTCGATCTCAAGTTGATCGGCTGGCTCAAGCGTGTGCGCGAGCAGGTGCGCCACGGTGCACAA
CCGCCGCACGAATTTCTTGAGCTCGGGCATCTGTTGCACGAGCAGCGGCTGTTCAAATCACGTGACGAAATCGCCTTGAT
GCAGCAGGCTGCCGACATCAGTGTGCGTGCGCATCGCGCGGCAATGCGGCTGGCGCGGCCGGGCGTGCATGAGTACGAAT
TGCAGGCCGAGGTCGAGCGCGAATTCCGCGCTGCCGACGCATGGCCGGCATACGGCAGCATCGTCGGCAGCGGCAGCAAC
GCCTGCGTGTTGCATTACCGCGCCAACAACGCGCGTAGTCGCGATGGCGAGCTGGTGCTGATCGATGCCGGTGCCGAATA
CCGCGGCTACGCGGCCGATATCACCCGCACCTTCCCGGTCAACGGCCGCTTCACGCCGGCGCAGCGCGCGCTGCACGATC
TGGTCGGTGCTGCGCAGGCGGCTGCACTCGCGCAGGCGCGCCCCGGCGTGGCCTACGAAGGGGGGCATCTGGCGGCGGTG
GAAACCTTGACCGAAGGCCTGCTGCGCCTGGGCCTGCTCAAGGGCAAGCTCGAGCGCAACATCGCCGATGGGCAGTACAA
GCGGTTTTATCGGCACAAGACCGGCCATTGGCTGGGTCTGGATGTGCACGATGTGGGCGACTACCGGCTGGCCGGCGACT
CACGGTTGCTCGAACCCGGCATGGTGTTCACCATCGAGCCGGGTCTGTACGTGTCTGCCGACGACACCTCGGTAGAGGCC
AAGTGGCGCGGCATCGGCATTCGTACTGAAGACAATGTGCTGATCACTGCCGATGGCCACCGCGTGCTCACCGATGCGTT
GGCGCGCAGTGCCGACGAGATTGAAGCGGAGATGGCGGATCGCGACGCAGCGCGCGCCTAG

Upstream 100 bases:

>100_bases
GCCGAGATCGAAGAATTCGTGCGCGTGGCGGTGCTGTTGCTGCATGGCGACTGCGTGATGGGGCCGCGTTTCCGCCAACG
TCTGAACTGATCGGTCCCCC

Downstream 100 bases:

>100_bases
CGCTGCAAGACCAACGAAAAACAGACGTGGCGCAGATCGGTGCAACGCGTTGCGAGCGCACTTGCGCTGCAGATGTCGTG
CCGACTACCCGGCACGCCCC

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAGPERVRSHDTHYPYRQDSDFWYLSGFPEPDAVLVLVPGRKHGEAILF
CRERDTEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRLARPGVHEYELQAEVEREFRAADAWPAYGSIVGSGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEGGHLAAV
ETLTEGLLRLGLLKGKLERNIADGQYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMADRDAARA

Sequences:

>Translated_446_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAGPERVRSHDTHYPYRQDSDFWYLSGFPEPDAVLVLVPGRKHGEAILF
CRERDTEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRLARPGVHEYELQAEVEREFRAADAWPAYGSIVGSGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEGGHLAAV
ETLTEGLLRLGLLKGKLERNIADGQYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMADRDAARA
>Mature_446_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAGPERVRSHDTHYPYRQDSDFWYLSGFPEPDAVLVLVPGRKHGEAILF
CRERDTEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRLARPGVHEYELQAEVEREFRAADAWPAYGSIVGSGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEGGHLAAV
ETLTEGLLRLGLLKGKLERNIADGQYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMADRDAARA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=451, Percent_Identity=36.8070953436807, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI149589008, Length=470, Percent_Identity=31.9148936170213, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=34.4262295081967, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI260593663, Length=464, Percent_Identity=28.2327586206897, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1789275, Length=439, Percent_Identity=45.3302961275626, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1790282, Length=285, Percent_Identity=31.9298245614035, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=32.2834645669291, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=464, Percent_Identity=31.8965517241379, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71989583, Length=370, Percent_Identity=27.5675675675676, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=451, Percent_Identity=29.7117516629712, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321118, Length=429, Percent_Identity=29.3706293706294, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19920384, Length=447, Percent_Identity=35.3467561521253, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21357079, Length=467, Percent_Identity=31.4775160599572, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49882; Mature: 49882

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAGPERVRSHDTHYPYRQDSDFWYLSGFP
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCEEEECCCC
EPDAVLVLVPGRKHGEAILFCRERDTEREAWDGPREGQEGAVERYGMDDAYPIDDVDEIL
CCCEEEEEECCCCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQPPHEFLELGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
RDEIALMQQAADISVRAHRAAMRLARPGVHEYELQAEVEREFRAADAWPAYGSIVGSGSN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQA
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
AALAQARPGVAYEGGHLAAVETLTEGLLRLGLLKGKLERNIADGQYKRFYRHKTGHWLGL
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
DVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEAKWRGIGIRTEDNVLITADGH
EEECCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEEEEEEECCCEEEEECCC
RVLTDALARSADEIEAEMADRDAARA
HHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAGPERVRSHDTHYPYRQDSDFWYLSGFP
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCEEEECCCC
EPDAVLVLVPGRKHGEAILFCRERDTEREAWDGPREGQEGAVERYGMDDAYPIDDVDEIL
CCCEEEEEECCCCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQPPHEFLELGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
RDEIALMQQAADISVRAHRAAMRLARPGVHEYELQAEVEREFRAADAWPAYGSIVGSGSN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQA
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
AALAQARPGVAYEGGHLAAVETLTEGLLRLGLLKGKLERNIADGQYKRFYRHKTGHWLGL
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
DVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEAKWRGIGIRTEDNVLITADGH
EEECCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEEEEEEECCCEEEEECCC
RVLTDALARSADEIEAEMADRDAARA
HHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]