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The map label for this gene is 84490319

Identifier: 84490319

GI number: 84490319

Start: 1720525

End: 1721748

Strand: Direct

Name: 84490319

Synonym: Msp_1541

Alternate gene names: NA

Gene position: 1720525-1721748 (Clockwise)

Preceding gene: 84490317

Following gene: 84490320

Centisome position: 97.35

GC content: 26.23

Gene sequence:

>1224_bases
ATGACAGAAAAAGAATATAATACAAGACAAACACAAAACTATGCTTTATGTCCTAAATGTCTATCTAGAATATATAGAAA
TCCAAAAGATAGAGACAATTCAATAATACCATTGATTAATAATACTCAAAAATGTAGTATTTGTAACAATCTACTTTTAA
ATGAAGATAAAATATTTAAACTTATTCTAAAAAAAATAAAGATGTTAAAAATTGAATTTGACACTTTTTTAATAGCAACA
CAAATAAATAATCAGACAATTACTAAAAATCAAAAAGAAATTTACAAAATAACAAATTATCATGGAAATAATGACATAAA
GCACCAAATAAGACGGGATATAAGTCGTTTAATTGAAGAAAAATTAGGTAAAACCTATGATTATAAAAATCCTGAAGTTG
TGATAATGGTAAAAATAAGAAAAAAACCATATAAACACAATCCATACCCAGAAATAAGTAATGTTAATATTTTTATTGAT
TCTAACCCAATATTTATTGAAGGTAAATATCGTAAGTTAGTACGTGGAATTCCACAAACAAAATGGCCATGTACACATTG
TAAAGGAAAAGGATGTGAAGCTTGTGATTATACAGGACAACAATATAAAGATACTGTTGAAGACCTAATATCAAGAGAGA
TACTTCCAATGACAAATGGAAACACGACAAAATTCCATGGATCTGGAAGAGAAGATATTGATGTTAGAATGTTAGGTGAA
GGTAGACCTTTTGTAATTGAAGTAAAACATCCCTTTAAAAGAAAAATCGATTTAAAATTTCTTAGAGTTCTTGTAAATAG
TCATAGTGATGGAAAAATAGAAATAAATGACTTAAAATACGTTACTAAAGAAAGAAAAGCAAGTATAAAAAATAGTTCTG
TTGAAAGTTACAAAATATACTCTGCAATAGCTGAATTTGAAAATGGAGTTACAAGTAAGGATATCTATAACATTGAAAAA
TTAAAAACCATAGATCAAAGAACTCCAATACGCGTAGAACATAGACGTGCTGATTTAATAAGAACAAGAGAAATTAAAAA
TATTGAAGTTGAACGGATAAATAGTAAAAAATTACATCTTATAATTAAATGTCAAGGTGGATTATATATCAAAGAACTTA
TATCTGGAGATAATAATCGTACAAAACCAAGTGTATCAAGTATAACCAATAATCAAGCAGAATGTACACAATTAGATGTT
TTAAAAGTACACATCCCAGAATAA

Upstream 100 bases:

>100_bases
TGCATAACCATTAACTTTTTAATAATAATTTATTTAATTAGATATATAAGAATTTAATAATAATATAGTATAATATAACA
TAGAATTATAGGAGTATTAA

Downstream 100 bases:

>100_bases
TAAAGATATAATTCAATTTCTATATAAACAATAGTTATACTTATAAACTATAAAATAAATAAATATTACACAATATTAAA
ACATAGAATATTATTCTAAT

Product: pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFKLILKKIKMLKIEFDTFLIAT
QINNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEEKLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFID
SNPIFIEGKYRKLVRGIPQTKWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGE
GRPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIYSAIAEFENGVTSKDIYNIEK
LKTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHLIIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDV
LKVHIPE

Sequences:

>Translated_407_residues
MTEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFKLILKKIKMLKIEFDTFLIAT
QINNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEEKLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFID
SNPIFIEGKYRKLVRGIPQTKWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGE
GRPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIYSAIAEFENGVTSKDIYNIEK
LKTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHLIIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDV
LKVHIPE
>Mature_406_residues
TEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFKLILKKIKMLKIEFDTFLIATQ
INNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEEKLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFIDS
NPIFIEGKYRKLVRGIPQTKWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGEG
RPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIYSAIAEFENGVTSKDIYNIEKL
KTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHLIIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDVL
KVHIPE

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=247, Percent_Identity=36.0323886639676, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17537241, Length=324, Percent_Identity=26.2345679012346, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920442, Length=251, Percent_Identity=34.6613545816733, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 47446; Mature: 47314

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFK
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHH
LILKKIKMLKIEFDTFLIATQINNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEE
HHHHHHHHEEEEEEEEEEEEECCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHH
KLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFIDSNPIFIEGKYRKLVRGIPQT
HHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCEEEEECHHHHHHCCCCCC
KWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCEEEEEECC
GRPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIY
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHH
SAIAEFENGVTSKDIYNIEKLKTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHL
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCEEEEECCCEEEE
IIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDVLKVHIPE
EEEECCCEEHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
TEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFK
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHH
LILKKIKMLKIEFDTFLIATQINNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEE
HHHHHHHHEEEEEEEEEEEEECCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHH
KLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFIDSNPIFIEGKYRKLVRGIPQT
HHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCEEEEECHHHHHHCCCCCC
KWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCEEEEEECC
GRPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIY
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHH
SAIAEFENGVTSKDIYNIEKLKTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHL
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCEEEEECCCEEEE
IIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDVLKVHIPE
EEEECCCEEHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]