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The map label for this gene is srp54

Identifier: 84490317

GI number: 84490317

Start: 1716177

End: 1717511

Strand: Direct

Name: srp54

Synonym: Msp_1539

Alternate gene names: 84490317

Gene position: 1716177-1717511 (Clockwise)

Preceding gene: 84490300

Following gene: 84490319

Centisome position: 97.1

GC content: 32.66

Gene sequence:

>1335_bases
ATGCTAGAAGGATTAAGTGAGAGTCTAACACAAACAATGAAAAAATTAGCGGGAATGTCTATAATCGATAAAAAAACATT
GAAAGATGTTACAAAGGATATACAAAGAGCACTCATACAATCAGATGTAAATGTTAAAGTAGTATTTGGTCTTACAAAAA
AAATAGAAAAACGAGCACTTGAAGAAGAATTACCAAAAGGACTAAGTCCTAAAGAACATGTAATGCGTATTGTATACCAA
GAGCTAGTAAATTTAATTGGTGAAAAACCTGAAGAACTAAAAATTAACAGGAAACCATACAAAATAATGATGTTAGGTCT
ACAAGGTAGTGGTAAAACAACTACAACAGCAAAATTAGTGAAACATCTGAAGAAAAAAGGACATACATCAGCAATAGTAT
GTACAGATACTTGGAGACCTGCAGCATATGAACAGTTAAGACAACTAACAGAACCATTAGATGTACCAGTATTTGGAGAT
CCTGAAAATAAGGATGCAATTGATCTTGCCAAGAAAGGACTTGAAAAATGTGGTTCTAAATACGATGTAATATTAGTTGA
TACAGCAGGAAGACATAAAGAAGAAAAAGACCTACTTGACGAAATGGCTGAATTAAGCCAAATAGTTCAACCTGATGAAG
TAATACTTGTTATAGATGGAACAATAGGACAACAAGCACGTAGCCAAGCAGAAACATTCAAGAAAACAACAGATATTGGT
TCAATTATAGTAAGTAAACTTGATGGATCTGCAAAAGGTGGAGGTGCATTATCTGCTGTAGCTGAAATAAGAGCACCAAT
AAAATTTATAGGTACAGGAGAACGTGTGGATGACTTTGAAGCATTTGATCCTGAAAGATTTATTTCACGATTACTTGGAA
TGGGCGACCTTGACACATTAATAGAAAAAGCTGCAGAAGTAACTTCAGAGAAATCTGATAAAGAAATGATAGATTCCATC
ATAAGTGGTAAATTTACATTAAAAGATATGGAAAATCAGTTAGAAATGATGAATAAAATGGGACCTATCCAACAAATAAT
GAAATTAATACCAGGTCTTGGTAATCAACTACCAGCCAATGCATCAAAAGTAACAGAAGAGAAACTAGGAATGTATAAAA
TACTAATGAATTCAATGACAACATATGAATTGGAAAATCCTGAAGTAATTAAAAAATCAAGAATAAATCGTATAAGTAGA
GGAGCAGGACTTACAAATGATGATGTTAAAGACCTACTTAAATACTATAATGTAACTAAGAAAGCCTTAAAAGGTATGGG
TAAACGTAACATGAGTGGACCTATGGGTAAACTTATGCGACATATGCAAAGATAA

Upstream 100 bases:

>100_bases
AATAGGAAAATATTTAGATAATTTTATTAAATTCATAATATCAATATAAAAGTAGATAAAAATAGTATTTAATTATAATC
TATTACCAAGGAGGTCAAAA

Downstream 100 bases:

>100_bases
CCCCCATTCACCTTTTATTTACCACACTTTTTTTCATAATCATCAATAATTTTATCAACACGTTTCTTAAATGTATGCTC
TTTTACAAGACTTGGATTAA

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLEGLSESLTQTMKKLAGMSIIDKKTLKDVTKDIQRALIQSDVNVKVVFGLTKKIEKRALEEELPKGLSPKEHVMRIVYQ
ELVNLIGEKPEELKINRKPYKIMMLGLQGSGKTTTTAKLVKHLKKKGHTSAIVCTDTWRPAAYEQLRQLTEPLDVPVFGD
PENKDAIDLAKKGLEKCGSKYDVILVDTAGRHKEEKDLLDEMAELSQIVQPDEVILVIDGTIGQQARSQAETFKKTTDIG
SIIVSKLDGSAKGGGALSAVAEIRAPIKFIGTGERVDDFEAFDPERFISRLLGMGDLDTLIEKAAEVTSEKSDKEMIDSI
ISGKFTLKDMENQLEMMNKMGPIQQIMKLIPGLGNQLPANASKVTEEKLGMYKILMNSMTTYELENPEVIKKSRINRISR
GAGLTNDDVKDLLKYYNVTKKALKGMGKRNMSGPMGKLMRHMQR

Sequences:

>Translated_444_residues
MLEGLSESLTQTMKKLAGMSIIDKKTLKDVTKDIQRALIQSDVNVKVVFGLTKKIEKRALEEELPKGLSPKEHVMRIVYQ
ELVNLIGEKPEELKINRKPYKIMMLGLQGSGKTTTTAKLVKHLKKKGHTSAIVCTDTWRPAAYEQLRQLTEPLDVPVFGD
PENKDAIDLAKKGLEKCGSKYDVILVDTAGRHKEEKDLLDEMAELSQIVQPDEVILVIDGTIGQQARSQAETFKKTTDIG
SIIVSKLDGSAKGGGALSAVAEIRAPIKFIGTGERVDDFEAFDPERFISRLLGMGDLDTLIEKAAEVTSEKSDKEMIDSI
ISGKFTLKDMENQLEMMNKMGPIQQIMKLIPGLGNQLPANASKVTEEKLGMYKILMNSMTTYELENPEVIKKSRINRISR
GAGLTNDDVKDLLKYYNVTKKALKGMGKRNMSGPMGKLMRHMQR
>Mature_444_residues
MLEGLSESLTQTMKKLAGMSIIDKKTLKDVTKDIQRALIQSDVNVKVVFGLTKKIEKRALEEELPKGLSPKEHVMRIVYQ
ELVNLIGEKPEELKINRKPYKIMMLGLQGSGKTTTTAKLVKHLKKKGHTSAIVCTDTWRPAAYEQLRQLTEPLDVPVFGD
PENKDAIDLAKKGLEKCGSKYDVILVDTAGRHKEEKDLLDEMAELSQIVQPDEVILVIDGTIGQQARSQAETFKKTTDIG
SIIVSKLDGSAKGGGALSAVAEIRAPIKFIGTGERVDDFEAFDPERFISRLLGMGDLDTLIEKAAEVTSEKSDKEMIDSI
ISGKFTLKDMENQLEMMNKMGPIQQIMKLIPGLGNQLPANASKVTEEKLGMYKILMNSMTTYELENPEVIKKSRINRISR
GAGLTNDDVKDLLKYYNVTKKALKGMGKRNMSGPMGKLMRHMQR

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=437, Percent_Identity=38.2151029748284, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI226371618, Length=376, Percent_Identity=39.8936170212766, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=51.3888888888889, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI23308697, Length=328, Percent_Identity=27.4390243902439, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI295424842, Length=328, Percent_Identity=27.4390243902439, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=34.3601895734597, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=31.4393939393939, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=436, Percent_Identity=36.697247706422, Blast_Score=305, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=28.0405405405405, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=394, Percent_Identity=37.8172588832487, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6320498, Length=325, Percent_Identity=25.8461538461538, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647949, Length=438, Percent_Identity=38.3561643835616, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24641198, Length=261, Percent_Identity=29.5019157088123, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_METST (Q2NE47)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448549.1
- ProteinModelPortal:   Q2NE47
- SMR:   Q2NE47
- STRING:   Q2NE47
- GeneID:   3854844
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1539
- NMPDR:   fig|339860.6.peg.1472
- eggNOG:   arNOG04631
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- PhylomeDB:   Q2NE47
- ProtClustDB:   PRK00771
- BioCyc:   MSTA339860:MSP_1539-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR008764
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- ProDom:   PD127708
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49395; Mature: 49395

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEGLSESLTQTMKKLAGMSIIDKKTLKDVTKDIQRALIQSDVNVKVVFGLTKKIEKRAL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
EEELPKGLSPKEHVMRIVYQELVNLIGEKPEELKINRKPYKIMMLGLQGSGKTTTTAKLV
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEEEECCCCCCHHHHHHH
KHLKKKGHTSAIVCTDTWRPAAYEQLRQLTEPLDVPVFGDPENKDAIDLAKKGLEKCGSK
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
YDVILVDTAGRHKEEKDLLDEMAELSQIVQPDEVILVIDGTIGQQARSQAETFKKTTDIG
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
SIIVSKLDGSAKGGGALSAVAEIRAPIKFIGTGERVDDFEAFDPERFISRLLGMGDLDTL
HHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCHHCCCHHHHHHHHHCCCCHHHH
IEKAAEVTSEKSDKEMIDSIISGKFTLKDMENQLEMMNKMGPIQQIMKLIPGLGNQLPAN
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
ASKVTEEKLGMYKILMNSMTTYELENPEVIKKSRINRISRGAGLTNDDVKDLLKYYNVTK
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KALKGMGKRNMSGPMGKLMRHMQR
HHHHCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLEGLSESLTQTMKKLAGMSIIDKKTLKDVTKDIQRALIQSDVNVKVVFGLTKKIEKRAL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
EEELPKGLSPKEHVMRIVYQELVNLIGEKPEELKINRKPYKIMMLGLQGSGKTTTTAKLV
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEEEECCCCCCHHHHHHH
KHLKKKGHTSAIVCTDTWRPAAYEQLRQLTEPLDVPVFGDPENKDAIDLAKKGLEKCGSK
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
YDVILVDTAGRHKEEKDLLDEMAELSQIVQPDEVILVIDGTIGQQARSQAETFKKTTDIG
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
SIIVSKLDGSAKGGGALSAVAEIRAPIKFIGTGERVDDFEAFDPERFISRLLGMGDLDTL
HHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCHHCCCHHHHHHHHHCCCCHHHH
IEKAAEVTSEKSDKEMIDSIISGKFTLKDMENQLEMMNKMGPIQQIMKLIPGLGNQLPAN
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
ASKVTEEKLGMYKILMNSMTTYELENPEVIKKSRINRISRGAGLTNDDVKDLLKYYNVTK
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KALKGMGKRNMSGPMGKLMRHMQR
HHHHCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA