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The map label for this gene is guaAA

Identifier: 84490099

GI number: 84490099

Start: 1476148

End: 1476708

Strand: Direct

Name: guaAA

Synonym: Msp_1311

Alternate gene names: 84490099

Gene position: 1476148-1476708 (Clockwise)

Preceding gene: 84490096

Following gene: 84490100

Centisome position: 83.52

GC content: 28.88

Gene sequence:

>561_bases
ATGAGCATTGTTATTATTAATAATTTTGGACAGTATAATCATAGAATATCTAGAACTTTGAAGTATTTGAATATAGAAAA
TAGTCTTATACCAAATACTACTAGTTTTGAAGAAATAGAGCAAATGAACCCTAAAGGCATTATTTTAGGTGGAGGTCCAT
CTATTGAACGTATAGGTAATTGTAAGGAAATTATCTTAAATATGGACATTCCAATTTTGGGAATATGTTTAGGACATCAA
ATTATAGCTGATGTCTTTGGTGGAGAAACTAAATCTGCAGAGATTGAAAGTTATGCACAAATAGAACTTAATATTCTTAA
GGAAAATGGTCTATTTAAAGGTATTGGTGATTCTCTTAAAGTATGGGCTTCTCATAAAGATGAAGTTGTTACTTTACCTG
AAAATTTTGAAATACTTGCAAACTCAGATAAATGTGATATTGAAGCTATGAAACATGAAGATAAAAATATATATGGTATT
CAATTCCACCCTGAAGTACAACACACACCACGTGGTGGAGAAATATTTGAAAACTTCAATAAAATATGTGAAAATTATTA
A

Upstream 100 bases:

>100_bases
ATAATATAATATATAGATAAAAGTAATATATAATAAATTATTAAATCAGTAATTTTTTTATTATAAAACTTATTTTAAAA
AAAAAATATGGGAATTTATC

Downstream 100 bases:

>100_bases
ATTAATTTAAAGGTTGAGTGAAATAAGATGATGATGGACACTACTAAATTTATAGAAGAATCAATAAAAAGTATAAAAGA
AGAAGTTAAGGATGAAAAAG

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSIVIINNFGQYNHRISRTLKYLNIENSLIPNTTSFEEIEQMNPKGIILGGGPSIERIGNCKEIILNMDIPILGICLGHQ
IIADVFGGETKSAEIESYAQIELNILKENGLFKGIGDSLKVWASHKDEVVTLPENFEILANSDKCDIEAMKHEDKNIYGI
QFHPEVQHTPRGGEIFENFNKICENY

Sequences:

>Translated_186_residues
MSIVIINNFGQYNHRISRTLKYLNIENSLIPNTTSFEEIEQMNPKGIILGGGPSIERIGNCKEIILNMDIPILGICLGHQ
IIADVFGGETKSAEIESYAQIELNILKENGLFKGIGDSLKVWASHKDEVVTLPENFEILANSDKCDIEAMKHEDKNIYGI
QFHPEVQHTPRGGEIFENFNKICENY
>Mature_185_residues
SIVIINNFGQYNHRISRTLKYLNIENSLIPNTTSFEEIEQMNPKGIILGGGPSIERIGNCKEIILNMDIPILGICLGHQI
IADVFGGETKSAEIESYAQIELNILKENGLFKGIGDSLKVWASHKDEVVTLPENFEILANSDKCDIEAMKHEDKNIYGIQ
FHPEVQHTPRGGEIFENFNKICENY

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=181, Percent_Identity=29.2817679558011, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1788854, Length=194, Percent_Identity=30.9278350515464, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789760, Length=183, Percent_Identity=26.775956284153, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787517, Length=192, Percent_Identity=25.5208333333333, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786215, Length=195, Percent_Identity=27.1794871794872, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=183, Percent_Identity=32.2404371584699, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992710, Length=183, Percent_Identity=32.2404371584699, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI133901714, Length=183, Percent_Identity=32.2404371584699, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323873, Length=182, Percent_Identity=37.3626373626374, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281365319, Length=186, Percent_Identity=32.7956989247312, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_METST (Q2NER5)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448331.1
- ProteinModelPortal:   Q2NER5
- SMR:   Q2NER5
- STRING:   Q2NER5
- GeneID:   3855939
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1311
- NMPDR:   fig|339860.6.peg.1257
- eggNOG:   arNOG05587
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BioCyc:   MSTA339860:MSP_1311-MONOMER
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 20948; Mature: 20817

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 76-76 ACT_SITE 163-163 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVIINNFGQYNHRISRTLKYLNIENSLIPNTTSFEEIEQMNPKGIILGGGPSIERIGN
CEEEEEECCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHCC
CKEIILNMDIPILGICLGHQIIADVFGGETKSAEIESYAQIELNILKENGLFKGIGDSLK
HHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEECCCCCEE
VWASHKDEVVTLPENFEILANSDKCDIEAMKHEDKNIYGIQFHPEVQHTPRGGEIFENFN
EEECCCCCEEECCCCCEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
KICENY
HHHCCC
>Mature Secondary Structure 
SIVIINNFGQYNHRISRTLKYLNIENSLIPNTTSFEEIEQMNPKGIILGGGPSIERIGN
EEEEEECCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHCC
CKEIILNMDIPILGICLGHQIIADVFGGETKSAEIESYAQIELNILKENGLFKGIGDSLK
HHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEECCCCCEE
VWASHKDEVVTLPENFEILANSDKCDIEAMKHEDKNIYGIQFHPEVQHTPRGGEIFENFN
EEECCCCCEEECCCCCEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
KICENY
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA