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The map label for this gene is guaAB [H]

Identifier: 84490100

GI number: 84490100

Start: 1476739

End: 1477665

Strand: Direct

Name: guaAB [H]

Synonym: Msp_1312

Alternate gene names: 84490100

Gene position: 1476739-1477665 (Clockwise)

Preceding gene: 84490099

Following gene: 84490101

Centisome position: 83.55

GC content: 32.25

Gene sequence:

>927_bases
ATGATGGACACTACTAAATTTATAGAAGAATCAATAAAAAGTATAAAAGAAGAAGTTAAGGATGAAAAAGTCATTATTGC
CTTATCTGGTGGAGTAGATAGTTCTGTTGCTTCAATTCTTGCATCAAAAGCTATTGGAAATCAACTCGAAGCAGTATTTG
TAGATCATGGTTTACTTAGAAAGAATGAAGCTAAAGAAGTTGAAGATACATTTAAAGATAGATTAAATTTTAAATTAGTT
AATGCCCAAGATGAATTTATAGAAGCATTAGATGGTGTAACAGATCCTGAAAAGAAACGTGAAATTATTGGTCACAAATT
TATTGAAGTATTTGAAAGAGAAGCTAAAAAATCAGGAGCTAAATACTTACTTCAAGGAACTATAGCACCAGACTGGATTG
AAAGTAAAGGAAATATAAAATCACACCACAATCTTACATTACCTGAAGGTTTAGTATTGAAAATTATAGAACCTTTACGT
GAATTATACAAAGATGAAGTAAGAGAAGTAGGTACTGCACTTGAATTACCTGATGCTATTGTTCACAGACAACCATTCCC
AGGGCCTGGACTTGCAGTAAGAGTTCTTGGAAACATTACAAAAGAAAAACTAGAAATTTGTAGAGAAGCTAATGCTATTC
TTACACAACACGTTGAAAACGAAGGATTAGATAAAGATTTATGGCAATATTTCGTAGTTTTAACAGATAGTAAAGTAACT
GGAGTAAAAGGAGATCAAAGAGACTTTGGATACCTTGTTGTTATACGAATGGTTCAATCATTCGATGCTATGACAGCAAA
TGTACCAGACATTCCATGGCCATTCCTACATAAAGTATCACAGGAAATTACTGCTAATGTTCCCGAAATAACACACGTAT
CTCTCTCATTAAGTAATAAACCACCTAGTACAATAGAATTTGAATAA

Upstream 100 bases:

>100_bases
TGAAGTACAACACACACCACGTGGTGGAGAAATATTTGAAAACTTCAATAAAATATGTGAAAATTATTAAATTAATTTAA
AGGTTGAGTGAAATAAGATG

Downstream 100 bases:

>100_bases
TTCTATAACCTCCTTTTAATTTTTATTAGTCTAATTAATTTTTAATTATAATACAAAAAATATTTAATTACTTTTTTTAA
AAAAAATAAAAAAAATAATA

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MMDTTKFIEESIKSIKEEVKDEKVIIALSGGVDSSVASILASKAIGNQLEAVFVDHGLLRKNEAKEVEDTFKDRLNFKLV
NAQDEFIEALDGVTDPEKKREIIGHKFIEVFEREAKKSGAKYLLQGTIAPDWIESKGNIKSHHNLTLPEGLVLKIIEPLR
ELYKDEVREVGTALELPDAIVHRQPFPGPGLAVRVLGNITKEKLEICREANAILTQHVENEGLDKDLWQYFVVLTDSKVT
GVKGDQRDFGYLVVIRMVQSFDAMTANVPDIPWPFLHKVSQEITANVPEITHVSLSLSNKPPSTIEFE

Sequences:

>Translated_308_residues
MMDTTKFIEESIKSIKEEVKDEKVIIALSGGVDSSVASILASKAIGNQLEAVFVDHGLLRKNEAKEVEDTFKDRLNFKLV
NAQDEFIEALDGVTDPEKKREIIGHKFIEVFEREAKKSGAKYLLQGTIAPDWIESKGNIKSHHNLTLPEGLVLKIIEPLR
ELYKDEVREVGTALELPDAIVHRQPFPGPGLAVRVLGNITKEKLEICREANAILTQHVENEGLDKDLWQYFVVLTDSKVT
GVKGDQRDFGYLVVIRMVQSFDAMTANVPDIPWPFLHKVSQEITANVPEITHVSLSLSNKPPSTIEFE
>Mature_308_residues
MMDTTKFIEESIKSIKEEVKDEKVIIALSGGVDSSVASILASKAIGNQLEAVFVDHGLLRKNEAKEVEDTFKDRLNFKLV
NAQDEFIEALDGVTDPEKKREIIGHKFIEVFEREAKKSGAKYLLQGTIAPDWIESKGNIKSHHNLTLPEGLVLKIIEPLR
ELYKDEVREVGTALELPDAIVHRQPFPGPGLAVRVLGNITKEKLEICREANAILTQHVENEGLDKDLWQYFVVLTDSKVT
GVKGDQRDFGYLVVIRMVQSFDAMTANVPDIPWPFLHKVSQEITANVPEITHVSLSLSNKPPSTIEFE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=367, Percent_Identity=32.425068119891, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1788854, Length=315, Percent_Identity=46.031746031746, Blast_Score=270, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI133901714, Length=368, Percent_Identity=30.4347826086957, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71992710, Length=368, Percent_Identity=30.4347826086957, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71992717, Length=368, Percent_Identity=30.4347826086957, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323873, Length=318, Percent_Identity=46.5408805031447, Blast_Score=258, Evalue=8e-70,
Organism=Drosophila melanogaster, GI281365319, Length=346, Percent_Identity=33.2369942196532, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 34508; Mature: 34508

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDTTKFIEESIKSIKEEVKDEKVIIALSGGVDSSVASILASKAIGNQLEAVFVDHGLLR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHC
KNEAKEVEDTFKDRLNFKLVNAQDEFIEALDGVTDPEKKREIIGHKFIEVFEREAKKSGA
CCHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KYLLQGTIAPDWIESKGNIKSHHNLTLPEGLVLKIIEPLRELYKDEVREVGTALELPDAI
CEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VHRQPFPGPGLAVRVLGNITKEKLEICREANAILTQHVENEGLDKDLWQYFVVLTDSKVT
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCC
GVKGDQRDFGYLVVIRMVQSFDAMTANVPDIPWPFLHKVSQEITANVPEITHVSLSLSNK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCC
PPSTIEFE
CCCCCCCC
>Mature Secondary Structure
MMDTTKFIEESIKSIKEEVKDEKVIIALSGGVDSSVASILASKAIGNQLEAVFVDHGLLR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHC
KNEAKEVEDTFKDRLNFKLVNAQDEFIEALDGVTDPEKKREIIGHKFIEVFEREAKKSGA
CCHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KYLLQGTIAPDWIESKGNIKSHHNLTLPEGLVLKIIEPLRELYKDEVREVGTALELPDAI
CEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VHRQPFPGPGLAVRVLGNITKEKLEICREANAILTQHVENEGLDKDLWQYFVVLTDSKVT
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCC
GVKGDQRDFGYLVVIRMVQSFDAMTANVPDIPWPFLHKVSQEITANVPEITHVSLSLSNK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCC
PPSTIEFE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]