Click here to switch to the map view.

The map label for this gene is hyi [H]

Identifier: 83721098

GI number: 83721098

Start: 2446911

End: 2447720

Strand: Reverse

Name: hyi [H]

Synonym: BTH_I2172

Alternate gene names: 83721098

Gene position: 2447720-2446911 (Counterclockwise)

Preceding gene: 83721511

Following gene: 83718596

Centisome position: 64.26

GC content: 66.79

Gene sequence:

>810_bases
ATGCCGAAATTCGCAGCCAACCTGACGATGCTGTTCAACGAAATGCCGTTCCTCGACCGCTTCGAGGCGGCGGCCGATGC
GGGATTCGGCGCCGTCGAGTTCCTGTTCCCGTATCCGTACGCGAAAGACGAGCTCGCCGAGCGTCTCGACGCCAATCGCC
TGCGCCTCGTGCTGCACAACCTGCCTGCGGGCAACTGGGATCAGGGCGAGCGCGGCATCGCCTGCCTGCCCGATCGCGTC
GGCGAATTCCAGGACGGTGTCGGCCGCGCGATCGACTATGCGCGCGCGCTGAAGGTGCCGCAGCTGAACTGCCTCGTTGG
CATTGCGCCCGCGAGCGTCGAGCGCGACACGGCGCTCGCGACGATCGTCGATAACCTGCGCTTCGCAGCCGCGGAACTGA
AGAAGGCGGGCCTGCGCCTTCTCGTCGAGCCGTGCAATGCGTACGACATCCCCGGCTTCGCGCTGAACCGCTCCGCCGAA
ACGCTCGACGTGATCCGCGCGGTTGGCGCCGACAACCTGTTCCTGCAGTACGACATCTACCACATGCAACGGATGGAGGG
CGAGCTCGCGGCGACGATTCGCAAGCACATCGGCTCGATCGCGCACATCCAGCTCGCGGACAATCCGGGCCGCCACGAGC
CCGGCACGGGCGAGATCAATTACGCGTACCTGTTCGATCTGCTCGACGCGCTCGGCTACGAAGGCTACGTCGGCTGCGAA
TACAAGCCGCGCGCGACGACGGCCGAAGGTCTCGGCTGGCTGCGGCAGATCGCGCGCGTCGACGCGCCGCGCGATCGCAC
CGACGCGTGA

Upstream 100 bases:

>100_bases
GCGCCTCGCGCCCATCGCTTCGCCTGCTTGATTGATCAGCATCGCTGATCAGCTTGACCGCTTCGACTTGCACAACCGAC
CGACCAGCGAGATGACCGAC

Downstream 100 bases:

>100_bases
CCCGGCACGCGCCCTCATCCACCCGTTCCGCATTCGACATTCACGGACTTACAGGAGACACCGCAATGGCAACGATCGGC
TTCATCGGCCTCGGCATCAT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPKFAANLTMLFNEMPFLDRFEAAADAGFGAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGNWDQGERGIACLPDRV
GEFQDGVGRAIDYARALKVPQLNCLVGIAPASVERDTALATIVDNLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAE
TLDVIRAVGADNLFLQYDIYHMQRMEGELAATIRKHIGSIAHIQLADNPGRHEPGTGEINYAYLFDLLDALGYEGYVGCE
YKPRATTAEGLGWLRQIARVDAPRDRTDA

Sequences:

>Translated_269_residues
MPKFAANLTMLFNEMPFLDRFEAAADAGFGAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGNWDQGERGIACLPDRV
GEFQDGVGRAIDYARALKVPQLNCLVGIAPASVERDTALATIVDNLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAE
TLDVIRAVGADNLFLQYDIYHMQRMEGELAATIRKHIGSIAHIQLADNPGRHEPGTGEINYAYLFDLLDALGYEGYVGCE
YKPRATTAEGLGWLRQIARVDAPRDRTDA
>Mature_268_residues
PKFAANLTMLFNEMPFLDRFEAAADAGFGAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGNWDQGERGIACLPDRVG
EFQDGVGRAIDYARALKVPQLNCLVGIAPASVERDTALATIVDNLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAET
LDVIRAVGADNLFLQYDIYHMQRMEGELAATIRKHIGSIAHIQLADNPGRHEPGTGEINYAYLFDLLDALGYEGYVGCEY
KPRATTAEGLGWLRQIARVDAPRDRTDA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=260, Percent_Identity=40.7692307692308, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=38.6831275720165, Blast_Score=157, Evalue=7e-39,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=55.9055118110236, Blast_Score=289, Evalue=1e-79,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=43.7007874015748, Blast_Score=233, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17552022, Length=254, Percent_Identity=38.5826771653543, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17530883, Length=260, Percent_Identity=33.8461538461538, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29714; Mature: 29583

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLFNEMPFLDRFEAAADAGFGAVEFLFPYPYAKDELAERLDANRLRLVLHN
CCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHH
LPAGNWDQGERGIACLPDRVGEFQDGVGRAIDYARALKVPQLNCLVGIAPASVERDTALA
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
TIVDNLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAETLDVIRAVGADNLFLQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATIRKHIGSIAHIQLADNPGRHEPGTGEINYAYLFDLLDALGYEGYVGCE
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPRATTAEGLGWLRQIARVDAPRDRTDA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PKFAANLTMLFNEMPFLDRFEAAADAGFGAVEFLFPYPYAKDELAERLDANRLRLVLHN
CCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHH
LPAGNWDQGERGIACLPDRVGEFQDGVGRAIDYARALKVPQLNCLVGIAPASVERDTALA
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
TIVDNLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAETLDVIRAVGADNLFLQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATIRKHIGSIAHIQLADNPGRHEPGTGEINYAYLFDLLDALGYEGYVGCE
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPRATTAEGLGWLRQIARVDAPRDRTDA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]