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The map label for this gene is glxR [H]

Identifier: 83718596

GI number: 83718596

Start: 2445940

End: 2446845

Strand: Reverse

Name: glxR [H]

Synonym: BTH_I2171

Alternate gene names: 83718596

Gene position: 2446845-2445940 (Counterclockwise)

Preceding gene: 83721098

Following gene: 83719465

Centisome position: 64.24

GC content: 69.54

Gene sequence:

>906_bases
ATGGCAACGATCGGCTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTGCTCAAGGGCGGTCACCGCCT
CGTCGTGAACGGCGCGTATCCGGTGCCCGCCGATCTGCGCGAGCGCACGCAGGTCGCCGCGAATTCGACGGCCGTCGCGC
GGGCGGCGGACATCGTGATCTCGATGGTGCCCGACACGCCCGACGTGCGCAACGTGCTGTTCGCCGACGACGGCGTCGCG
AAGGGCCTGTCGGCCGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCGCGAGTTCGCGAAGGAGAT
CAACGCGCTCGGCTGCGACTATCTCGACGCGCCCGTGTCGGGCGGCGAGGTCGGCGCACGCGACGCGACGCTCACGATCA
TGGTCGGCGGCCCGCAGCGCGCGTTCGAGCAGGCGAAGCCGCTCCTCGAACTGATGGGCAAGAACGTCTCGCTGATCGGC
GAGAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCGGTCGCGGAGGCGCT
CCTCTTCGCCGCGCGCTCGGGCGCGGACCCGGAGCGCGTGCGGCGCGCGCTGATGGGCGGCTTCGCGTCGTCGCGGATTC
TCGAGCTGCACGGCGAGCGGATGACGAAGCGCACGTTCGATCCGGGCTTCCGGATCGACCTGCATCGCAAGGATCTGAAC
CTCGCGCTCGACGGCGCGCGCCGGATGAACATCGCGCTGCCCCACACGGCAAGCGCGCAGCAGCTCTTCAGCGTGTGCGC
GGCGAACGGCGGCGGCGCATGGGACCACTCGGCGATCGTGCGCGCGCTCGAGATCATGTCGAACTTCGAGATCGGCGAGC
CGCAGCGTGACGAGAAGCTCGCGTGA

Upstream 100 bases:

>100_bases
GCGTCGACGCGCCGCGCGATCGCACCGACGCGTGACCCGGCACGCGCCCTCATCCACCCGTTCCGCATTCGACATTCACG
GACTTACAGGAGACACCGCA

Downstream 100 bases:

>100_bases
GCGAACGTGTCGGCGCGTCGAGTCGCGCCGATGCGGGCAAGCCTGGAGAGCGTGAAGTCGCGGTGAAGCGGCACGGTGAG
GCGGCACGGAGAAGCGCCGC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLRERTQVAANSTAVARAADIVISMVPDTPDVRNVLFADDGVA
KGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFEQAKPLLELMGKNVSLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFDPGFRIDLHRKDLN
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNFEIGEPQRDEKLA

Sequences:

>Translated_301_residues
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLRERTQVAANSTAVARAADIVISMVPDTPDVRNVLFADDGVA
KGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFEQAKPLLELMGKNVSLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFDPGFRIDLHRKDLN
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNFEIGEPQRDEKLA
>Mature_300_residues
ATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLRERTQVAANSTAVARAADIVISMVPDTPDVRNVLFADDGVAK
GLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFEQAKPLLELMGKNVSLIGE
NGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFDPGFRIDLHRKDLNL
ALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNFEIGEPQRDEKLA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=32.4590163934426, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=28.0141843971631, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=61.5916955017301, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=42.7586206896552, Blast_Score=235, Evalue=2e-63,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=35.8620689655172, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=31.6901408450704, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=34.0277777777778, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=34.0350877192982, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=34.0350877192982, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=27.5618374558304, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31920; Mature: 31789

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLRERTQVAANSTAVARAADIVI
CCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHEEE
SMVPDTPDVRNVLFADDGVAKGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVS
EECCCCCCHHEEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPQRAFEQAKPLLELMGKNVSLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCEEEEEEEH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFDPGFRIDLHRKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNFEIGEPQRDEKL
EEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLRERTQVAANSTAVARAADIVI
CEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHEEE
SMVPDTPDVRNVLFADDGVAKGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVS
EECCCCCCHHEEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPQRAFEQAKPLLELMGKNVSLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCEEEEEEEH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFDPGFRIDLHRKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNFEIGEPQRDEKL
EEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]