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The map label for this gene is hemD [H]

Identifier: 83720469

GI number: 83720469

Start: 996133

End: 998112

Strand: Direct

Name: hemD [H]

Synonym: BTH_I0873

Alternate gene names: 83720469

Gene position: 996133-998112 (Clockwise)

Preceding gene: 83720099

Following gene: 83718445

Centisome position: 26.15

GC content: 69.29

Gene sequence:

>1980_bases
ATGGCGGGCGCGCCGCGCACGTTCACCGCGGTGCTCACGCGTCCCGACGGACAGTCGGCGGCGCTCGCGGCGCAACTCGC
CGCAGCGGGCATCGACACGCTCGACTTTCCGCTCATCGACATCGCGCCGCTTGCCGACGACGCGCCGCTCGCCGAGGCGT
TCGCGCGGCTCGATGCGTACGCGCTCGTCGTGTTCGTGTCGCCGAACGCGATCGATCGCGCGCTCGCGCGGCTCGGCGCG
ATCTGGCCGCATCCGCTGCCGATCGGCGTCGTCGGGCCGGGCAGCGTCGCCGCGCTCGCGCGGCACGGAGTCGCCGTGCC
CGCGCATCGTGTGATCGCGCCGCGCGCGCCCGACGACGGCGGCGAGCCGCACTACGATTCCGAGAGCCTGTTCGCCGAGA
TCGCGCGCGCGTTCGACGGCGAGGCGAAGCTCGCCGGCAAGCGCGTGCTGATCGTGCGCGGCGACGGCGGACGCGAATGG
CTCGCCGAGCGCCTGCGCGAAGCGGGCGCCGAAGTCGAGCTCGTCGCCGCGTATCGGCGCGTGAGCCCGGAGCCCTCGAT
CGGCACGTGGGAGCGCGTGCACGCGCTGCTGTCGGGCGCGCCGCACGCGTGGCTCGTGACGAGCTCGGAAGGCGTGCGCA
ATCTGCAGGAGCTCGCGCACGAGCATTTGAACGAAACCGAGATCGACGCGCTCAGGCGTGCGCAGTTCGTCGCGCCGCAT
CCGAGGATCGTCGAGACCGCGCGCGCACTCGGTTTTGATAGGATTACGCTGTCCGGCGCGGGCGATGAGCGTATCGTCCG
CACCTTTCGTACGTTGGCCGATCAGGCCGATCAACCGGCGACAGCCGCACCGATGCCTTCTCGCATGACAGACACCAACG
ATACCAAAGACGTCTCTTCCAAACAGGCTGCGGCCCCCGATGCGCCGCGGAATCAACCGTTTACGCCGTTTGAAACGAAA
GCGCGGCGCAGCGGCTCGAGCGCGGCGCTGTGGTTCGTGGTCGTCGTGATCGCGGCCGCGGCGGGCGTCGGCGGCTATGC
GCTGAACCGCAAGGTCGACCGCCTCGACCAGCATGCGTTCGAGCGCCAGAAGGTGCTCGACGCGCAGACGGCCGAGCTGC
GCACGAAGACCGATCAGGCGCTCGCGAGCGTGCGTCAGGCGGATTCGCAACTGTCGCAGCTCGAAGGCAAGCTCGCCGAT
GCGCAAACCGCGCAGACCGCGTTGCAGCAGCAATATCAGGACCTGTCGCGCAACCGCGACGCATGGATGATCGAGGAAGT
CGGCCAGATGCTGTCGAGCGCGAGCCAGCAGCTCCTCTTGACGGGCAACACGCAGCTCGCGCTGATCGCGCTGCAAAACG
CCGATTCGCGGCTCGCTTCGTCGCAGAGCGCGCAGGCCGTCGTCGTGCGCAAGGCGATCGCACAGGACATCGAACGATTG
AAGGCCGCGCCGTCGGCGGACCTCACCGGGCTTGCGATCAAGCTCGATGACGCAATCGCGAAAATCGACACGCTGCCGCT
CGCGGGCGAAGTGCTCGCGCCGCACGCGCAGGCGAAGCCCGACGTTGCCGCGAGCGCCGAGCAGGCGGCCGCGGCGGCGG
GCGAGCCGCGCTGGAAGGCGTGGTGGCGAGGCTTTTCGGCGGGCATCGGCGCGCAACTGAAGTCGCTCGTCGAAGTGCGC
CGCATCGATCAAGCGGACGCGATGCTCGCGTCGCCCGAGCAAGGCTACTTCGTGCGCGAGAACGTGAAGCTGCGGCTTCT
GAGCGCGCGGCTGTCGCTGCTCGCGCGCGACGACAGCGCGATGAAATCCGATCTGCATGCCGCGCAGGCGGCCGTCGCGC
GCTACTTCGACGGCGCGTCGAAGGACACCCGGATCGTTCAGGATCTGCTCAAGCAGGTCGACGCCGCGTCGCTCACGGTC
GCGGTGCCGAACCTCAACACGAGCCTGAACGCGGTTCAACAGTTCAAGAGCCGGGGTTGA

Upstream 100 bases:

>100_bases
TCGGCCGCGCGGTGTCCGACGAGCTCGAGCGGCAGGGCGCGCGCGCGATCGTCGACGCGCTCGTCGCGGCGAGCGCGCAA
GCGCAGAAGGGCGGCGCGTG

Downstream 100 bases:

>100_bases
CGCCATGACGCTGCGTGGAATCATTTGGCTCGCCGTGCTGTTCGCGATCGCCGCGGCGCTCGCGACGGTCGGGCGCTTCG
ATGCCGGCCAGGTGCTGATC

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAIDRALARLGA
IWPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDGGEPHYDSESLFAEIARAFDGEAKLAGKRVLIVRGDGGREW
LAERLREAGAEVELVAAYRRVSPEPSIGTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPH
PRIVETARALGFDRITLSGAGDERIVRTFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKQAAAPDAPRNQPFTPFETK
ARRSGSSAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAFERQKVLDAQTAELRTKTDQALASVRQADSQLSQLEGKLAD
AQTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADSRLASSQSAQAVVVRKAIAQDIERL
KAAPSADLTGLAIKLDDAIAKIDTLPLAGEVLAPHAQAKPDVAASAEQAAAAAGEPRWKAWWRGFSAGIGAQLKSLVEVR
RIDQADAMLASPEQGYFVRENVKLRLLSARLSLLARDDSAMKSDLHAAQAAVARYFDGASKDTRIVQDLLKQVDAASLTV
AVPNLNTSLNAVQQFKSRG

Sequences:

>Translated_659_residues
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAIDRALARLGA
IWPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDGGEPHYDSESLFAEIARAFDGEAKLAGKRVLIVRGDGGREW
LAERLREAGAEVELVAAYRRVSPEPSIGTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPH
PRIVETARALGFDRITLSGAGDERIVRTFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKQAAAPDAPRNQPFTPFETK
ARRSGSSAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAFERQKVLDAQTAELRTKTDQALASVRQADSQLSQLEGKLAD
AQTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADSRLASSQSAQAVVVRKAIAQDIERL
KAAPSADLTGLAIKLDDAIAKIDTLPLAGEVLAPHAQAKPDVAASAEQAAAAAGEPRWKAWWRGFSAGIGAQLKSLVEVR
RIDQADAMLASPEQGYFVRENVKLRLLSARLSLLARDDSAMKSDLHAAQAAVARYFDGASKDTRIVQDLLKQVDAASLTV
AVPNLNTSLNAVQQFKSRG
>Mature_658_residues
AGAPRTFTAVLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAIDRALARLGAI
WPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDGGEPHYDSESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWL
AERLREAGAEVELVAAYRRVSPEPSIGTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPHP
RIVETARALGFDRITLSGAGDERIVRTFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKQAAAPDAPRNQPFTPFETKA
RRSGSSAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAFERQKVLDAQTAELRTKTDQALASVRQADSQLSQLEGKLADA
QTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADSRLASSQSAQAVVVRKAIAQDIERLK
AAPSADLTGLAIKLDDAIAKIDTLPLAGEVLAPHAQAKPDVAASAEQAAAAAGEPRWKAWWRGFSAGIGAQLKSLVEVRR
IDQADAMLASPEQGYFVRENVKLRLLSARLSLLARDDSAMKSDLHAAQAAVARYFDGASKDTRIVQDLLKQVDAASLTVA
VPNLNTSLNAVQQFKSRG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790235, Length=284, Percent_Identity=23.943661971831, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790236, Length=268, Percent_Identity=27.2388059701493, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 70394; Mature: 70263

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAY
CCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCEE
ALVVFVSPNAIDRALARLGAIWPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDG
EEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHHEECCCCCCCC
GEPHYDSESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRR
CCCCCCHHHHHHHHHHHHCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VSPEPSIGTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPH
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
PRIVETARALGFDRITLSGAGDERIVRTFRTLADQADQPATAAPMPSRMTDTNDTKDVSS
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCH
KQAAAPDAPRNQPFTPFETKARRSGSSAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAF
HHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ERQKVLDAQTAELRTKTDQALASVRQADSQLSQLEGKLADAQTAQTALQQQYQDLSRNRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADSRLASSQSAQAVVVRKAIAQDIERL
CHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHH
KAAPSADLTGLAIKLDDAIAKIDTLPLAGEVLAPHAQAKPDVAASAEQAAAAAGEPRWKA
HCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHH
WWRGFSAGIGAQLKSLVEVRRIDQADAMLASPEQGYFVRENVKLRLLSARLSLLARDDSA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCHH
MKSDLHAAQAAVARYFDGASKDTRIVQDLLKQVDAASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AGAPRTFTAVLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAY
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCEE
ALVVFVSPNAIDRALARLGAIWPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDG
EEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHHEECCCCCCCC
GEPHYDSESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRR
CCCCCCHHHHHHHHHHHHCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VSPEPSIGTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPH
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
PRIVETARALGFDRITLSGAGDERIVRTFRTLADQADQPATAAPMPSRMTDTNDTKDVSS
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCH
KQAAAPDAPRNQPFTPFETKARRSGSSAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAF
HHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ERQKVLDAQTAELRTKTDQALASVRQADSQLSQLEGKLADAQTAQTALQQQYQDLSRNRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADSRLASSQSAQAVVVRKAIAQDIERL
CHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHH
KAAPSADLTGLAIKLDDAIAKIDTLPLAGEVLAPHAQAKPDVAASAEQAAAAAGEPRWKA
HCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHH
WWRGFSAGIGAQLKSLVEVRRIDQADAMLASPEQGYFVRENVKLRLLSARLSLLARDDSA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCHH
MKSDLHAAQAAVARYFDGASKDTRIVQDLLKQVDAASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]