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The map label for this gene is hemC [H]

Identifier: 83720099

GI number: 83720099

Start: 995144

End: 996133

Strand: Direct

Name: hemC [H]

Synonym: BTH_I0872

Alternate gene names: 83720099

Gene position: 995144-996133 (Clockwise)

Preceding gene: 83719907

Following gene: 83720469

Centisome position: 26.12

GC content: 73.23

Gene sequence:

>990_bases
ATGAACTCCGAGACTCTTCCGGCCGAGCTGCCCGCGACGCTGACGATCGCGTCGCGCGAGAGCCGCCTCGCCATGTGGCA
AGCCGAGCATGTGCGTGATGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGATGACGACGCGCGGCG
ATCAAATTCTCGATCGCACGCTGTCGAAGGTCGGCGGCAAGGGCTTGTTCGTGAAGGAGCTCGAGAGCGCGCTCGCCGAC
GGCCGCGCGGATCTCGCCGTGCATTCGCTGAAGGACGTGCCGATGGAGCTGCCCGCGGGCTTCGCGCTCGCGGCCGTGAT
GAGCCGCGAGGACCCGCGCGACGCGTTCGTGTCGAACGATTACGCGTCGCTCGACGCGCTGCCGGCGGGCGCCGTCGTCG
GCACGTCGAGCCTGCGCCGCGAGGCGATGCTGCGCGCGCGCTATCCGCGGCTCGACGTGCGGCCGCTGCGCGGCAATCTC
GACACGCGGCTCGCGAAGCTCGACCGCGGCGATTACGCGGCGATCATTCTCGCCGCCGCGGGCCTGAAGCGCCTCGGTCT
CGCCGCGAGGATCCGCGCGTTGCTCGACGTCGAAGACAGCCTGCCCGCCGCAGGCCAGGGCGCGCTCGGCATCGAGATCG
CCGCAGGCCGCGCGGACGTCGCCGCGTGGCTCGCGCCGTTGCACGATCATGCGACCGCGCTCGCGGTCGAGGCCGAACGC
GCGGTGTCGCGCGCGCTCGGCGGCAGCTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGGCGACGAGCTGCACCT
GACGGGCAGCGTGTCGACGACGGACGGCGCGCGCGTGCTCGCCGCGCGCGCGCAGTCGCGCGCGGCGACGGCCGCCGACG
CGCTCGCGCTCGGCCGCGCGGTGTCCGACGAGCTCGAGCGGCAGGGCGCGCGCGCGATCGTCGACGCGCTCGTCGCGGCG
AGCGCGCAAGCGCAGAAGGGCGGCGCGTGA

Upstream 100 bases:

>100_bases
GACCGTGCGGGCCGCTCGCGCAGCCCGCCAGGCGGGCGGTCGCGCGAGATGCGCGTGCTACCATAGTCTGTTCCTAATCC
CGCCTTTCGATGTCCCTGCA

Downstream 100 bases:

>100_bases
TGGCGGGCGCGCCGCGCACGTTCACCGCGGTGCTCACGCGTCCCGACGGACAGTCGGCGGCGCTCGCGGCGCAACTCGCC
GCAGCGGGCATCGACACGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAER
AVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRAVSDELERQGARAIVDALVAA
SAQAQKGGA

Sequences:

>Translated_329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAER
AVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRAVSDELERQGARAIVDALVAA
SAQAQKGGA
>Mature_329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAER
AVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRAVSDELERQGARAIVDALVAA
SAQAQKGGA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=277, Percent_Identity=45.1263537906137, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI66933009, Length=275, Percent_Identity=45.4545454545455, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI48994974, Length=315, Percent_Identity=53.015873015873, Blast_Score=300, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=38.5579937304075, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI20130425, Length=278, Percent_Identity=44.9640287769784, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34422; Mature: 34422

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELESALADGRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC
YASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAER
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
AVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRA
HHHHHCCCCCCCCHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSDELERQGARAIVDALVAASAQAQKGGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELESALADGRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC
YASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAER
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
AVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRA
HHHHHCCCCCCCCHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSDELERQGARAIVDALVAASAQAQKGGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA