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The map label for this gene is kynA [H]

Identifier: 83719842

GI number: 83719842

Start: 818322

End: 819272

Strand: Reverse

Name: kynA [H]

Synonym: BTH_I0709

Alternate gene names: 83719842

Gene position: 819272-818322 (Counterclockwise)

Preceding gene: 83719525

Following gene: 83718942

Centisome position: 21.51

GC content: 67.72

Gene sequence:

>951_bases
ATGGAGACAATCGTGAATTCAGGTCACATGCAGCCGCCCCGCGACGACGACGCGCCCCGCTGCCCGTTCGCCGGCGCTCA
CGCGCCCGACGCGCCGCACGTGAGCCCCGCCGCCGGCGAAGACGACGCGCAGGCCGGCTGGCATCGCGCGCAGCTCGACT
TCTCGCAGTCGATGAGCTACGGCGATTATCTGTCGCTCGATCCGATCCTCGATGCGCAACATCCGCGCTCGCCCGATCAC
AACGAGATGCTGTTCATCATCCAGCATCAGACGAGCGAGCTGTGGATGAAGCTCGCGCTCTACGAGCTGCGCGCGGCGCT
CGCGTCGATCCGTGACGACGCGCTGCCGCCCGCGTTCAAGATGCTCGCGCGCGTGTCGCGCGTGCTCGAGCAGCTCGTGC
AGGCATGGAACGTGCTCGCGACGATGACGCCGTCCGAGTATTCGGCGATGCGGCCGTACCTGGGCGCGTCGTCGGGTTTC
CAGTCGTACCAGTATCGCGAGCTCGAGTTCATCCTCGGCAACAAGAACGCGCAGATGCTGCGTCCGCATGCGCACCGGCC
GGCGATCCACGCGCATCTCGAGGCGTCGCTGCAATCGCCTTCGCTGTACGACGAAGTGATTCGCCTGCTCGCGCGCCGCG
GCTTTCCGATCGCGCCCGAGCGGCTCGACGCGGACTGGACGCAGCCGACGCGCCACGATCCGACCGTCGAGGCCGCGTGG
CTCGCCGTGTACCGCGAGCCGAACGCGCACTGGGAGCTGTACGAGATGGCCGAAGAGCTCGTCGATCTCGAGGACGCGTT
CCGCCAATGGCGCTTCCGCCACGTGACGACGGTCGAGCGGATCATCGGCTTCAAGCAGGGCACGGGCGGCACGAGCGGCG
CGCCGTATCTGCGCAAGATGCTCGACGTCGTGCTGTTCCCCGAGCTCTGGCACGTGCGCACGACGCTGTAG

Upstream 100 bases:

>100_bases
GCGACGCGCGCCGCGGTGACCTGAGCCCGCGCGAGCGCCGCGCGATCCGCGCGGCGGCGCTCGGCCGGTTGACCGCCCCG
CGACGCCACACATTTATTCC

Downstream 100 bases:

>100_bases
CGCGCGCCCGCCGCACACACGCACGCGGGCGGGCGGCGAAGCGTCGGAACGTCAGGGGGCCGCGCGCGCGAGCTCGTCGC
TCGCCGGCAGCCCGCCGCGG

Product: tryptophan 2,3-dioxygenase family protein

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
METIVNSGHMQPPRDDDAPRCPFAGAHAPDAPHVSPAAGEDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDH
NEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGF
QSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQSPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDPTVEAAW
LAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_316_residues
METIVNSGHMQPPRDDDAPRCPFAGAHAPDAPHVSPAAGEDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDH
NEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGF
QSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQSPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDPTVEAAW
LAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_316_residues
METIVNSGHMQPPRDDDAPRCPFAGAHAPDAPHVSPAAGEDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDH
NEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGF
QSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQSPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDPTVEAAW
LAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=166, Percent_Identity=37.3493975903614, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32564651, Length=175, Percent_Identity=30.2857142857143, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=175, Percent_Identity=30.2857142857143, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17530891, Length=373, Percent_Identity=28.686327077748, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 35970; Mature: 35970

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIVNSGHMQPPRDDDAPRCPFAGAHAPDAPHVSPAAGEDDAQAGWHRAQLDFSQSMSY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHCCHHHCCCC
GDYLSLDPILDAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
MLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQML
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCHHHC
RPHAHRPAIHAHLEASLQSPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDPTVEAAW
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHH
LAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKM
HEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LDVVLFPELWHVRTTL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
METIVNSGHMQPPRDDDAPRCPFAGAHAPDAPHVSPAAGEDDAQAGWHRAQLDFSQSMSY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHCCHHHCCCC
GDYLSLDPILDAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
MLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQML
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCHHHC
RPHAHRPAIHAHLEASLQSPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDPTVEAAW
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHH
LAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKM
HEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LDVVLFPELWHVRTTL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA