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The map label for this gene is kynU [H]

Identifier: 83719525

GI number: 83719525

Start: 819349

End: 820599

Strand: Reverse

Name: kynU [H]

Synonym: BTH_I0710

Alternate gene names: 83719525

Gene position: 820599-819349 (Counterclockwise)

Preceding gene: 83720049

Following gene: 83719842

Centisome position: 21.54

GC content: 69.62

Gene sequence:

>1251_bases
ATGAAAACACGTGAAGAAGCGCTCGCGCTCGATCGCGACGACCCGCTCGCGCCATTGCGCGACCAGTTCGCGCTGCCCGC
CGGCGTGATCTACCTCGACGGCAATTCGCTCGGCGCGCAGCCGCGCGCGTCGGCCGCCCGCGCGCAGCAGGTGATCGGCG
CCGAATGGGGCGAAGGCCTCATCCGCAGCTGGAACACGGCCGGCTGGTTCGCGCTGCCGCGCCGGCTCGGCGACAGGCTC
GCGCCGATGATCGGCGCGGCGCAAGGCGAAGTCGCGATCACCGACACGATCTCGATCAACCTGTTCAAGCTGCTCTCCGC
GATGCTGCGGCATCAGGCCCGGCACGCGCCGAAGCGCCGCGTGATCGTGTCCGAACGCTCGAACTTCCCGACTGATCTGT
ACATCGCGCAGGGCCTGATCGCGCAGCTCGACCGCGACTACGAGCTGCGCCTCGTCGACGACCCGGCCGACCTGCCCGAC
GCGCTCGACGACGAAACCGCCGTCGCGATGATCACGCACGTGAACTACCGCACGGGCTACATGCACGACATGCCGTCCGT
CACGCAGACGGTCCACCAGGCGGGCGCGCTGATGCTGTGGGATCTCGCGCATTCGGCGGGCGCGGTGCCCGTCGATCTGA
ACGGCGCGCTCGCGGATGGCGCGCTCGGCTGCACGTACAAGTATCTGAACGGCGGCCCCGGCTCGCCCGCGTTCGTCTGG
GTGCCCAAGCGCCATCAGCAGGCGTTCGAGCAGCCGCTGTCCGGCTGGTGGGGCCACCGCGCGCCGTTCGCGATGCAGCC
CGCGTTCGAGCCCGATCCGGGCATCGCGCGCTTTCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCGAATGCG
GGCTCGACGTGTTCGCGCAAACCGACATGCACGCGATCCGCCGCAAGTCCCTCGCGCTGACCGACGCGTTCATCGCGCTC
GTCGAAGCGCGCTGCGCGGGCCAGCCGCTCAGGCTCGTCACGCCGCGCGCGCATCATCAGCGCGGCTCGCAGGCGAGCTT
CGAGCATCCGCACGGCTACGAAGTGATGCAGGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAGCCGCACATCC
TGCGCTTCGGCTTCACGCCGCTCTACACGCGCTTCGTCGACGTGTGGGACGCGGTCGAGACGCTGCGCGACATTCTCGAA
ACCGAAGCGTGGCGCGCGAGCGAATTCGCGACGCGCGCCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
CGATGCAAGCCCCGTGCGCGCGGTGCTGCGCGCGCTGCCCGACGCGCCGCGCTGAAGAAAAGCGGACGCGATCGCCCCTC
CCCCAACCAGGTTCGACATC

Downstream 100 bases:

>100_bases
GCCCGCGCGAGCGCCGCGCGATCCGCGCGGCGGCGCTCGGCCGGTTGACCGCCCCGCGACGCCACACATTTATTCCATGG
AGACAATCGTGAATTCAGGT

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTREEALALDRDDPLAPLRDQFALPAGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APMIGAAQGEVAITDTISINLFKLLSAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQLDRDYELRLVDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVHQAGALMLWDLAHSAGAVPVDLNGALADGALGCTYKYLNGGPGSPAFVW
VPKRHQQAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFIAL
VEARCAGQPLRLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPHILRFGFTPLYTRFVDVWDAVETLRDILE
TEAWRASEFATRAAVT

Sequences:

>Translated_416_residues
MKTREEALALDRDDPLAPLRDQFALPAGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APMIGAAQGEVAITDTISINLFKLLSAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQLDRDYELRLVDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVHQAGALMLWDLAHSAGAVPVDLNGALADGALGCTYKYLNGGPGSPAFVW
VPKRHQQAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFIAL
VEARCAGQPLRLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPHILRFGFTPLYTRFVDVWDAVETLRDILE
TEAWRASEFATRAAVT
>Mature_416_residues
MKTREEALALDRDDPLAPLRDQFALPAGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APMIGAAQGEVAITDTISINLFKLLSAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQLDRDYELRLVDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVHQAGALMLWDLAHSAGAVPVDLNGALADGALGCTYKYLNGGPGSPAFVW
VPKRHQQAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFIAL
VEARCAGQPLRLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPHILRFGFTPLYTRFVDVWDAVETLRDILE
TEAWRASEFATRAAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=444, Percent_Identity=27.4774774774775, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI74101437, Length=290, Percent_Identity=25.1724137931034, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17550466, Length=438, Percent_Identity=26.4840182648402, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=30.4824561403509, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45878; Mature: 45878

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTREEALALDRDDPLAPLRDQFALPAGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGL
CCCHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHH
IRSWNTAGWFALPRRLGDRLAPMIGAAQGEVAITDTISINLFKLLSAMLRHQARHAPKRR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQLDRDYELRLVDDPADLPDALDDETAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCC
MHDMPSVTQTVHQAGALMLWDLAHSAGAVPVDLNGALADGALGCTYKYLNGGPGSPAFVW
CCCCCHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEE
VPKRHQQAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
TDMHAIRRKSLALTDAFIALVEARCAGQPLRLVTPRAHHQRGSQASFEHPHGYEVMQALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPHILRFGFTPLYTRFVDVWDAVETLRDILETEAWRASEFATRAAVT
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKTREEALALDRDDPLAPLRDQFALPAGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGL
CCCHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHH
IRSWNTAGWFALPRRLGDRLAPMIGAAQGEVAITDTISINLFKLLSAMLRHQARHAPKRR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQLDRDYELRLVDDPADLPDALDDETAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCC
MHDMPSVTQTVHQAGALMLWDLAHSAGAVPVDLNGALADGALGCTYKYLNGGPGSPAFVW
CCCCCHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEE
VPKRHQQAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
TDMHAIRRKSLALTDAFIALVEARCAGQPLRLVTPRAHHQRGSQASFEHPHGYEVMQALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPHILRFGFTPLYTRFVDVWDAVETLRDILETEAWRASEFATRAAVT
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA