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The map label for this gene is coaBC [H]

Identifier: 83718888

GI number: 83718888

Start: 883568

End: 884779

Strand: Reverse

Name: coaBC [H]

Synonym: BTH_I0768

Alternate gene names: 83718888

Gene position: 884779-883568 (Counterclockwise)

Preceding gene: 83721661

Following gene: 83718436

Centisome position: 23.23

GC content: 69.55

Gene sequence:

>1212_bases
TTGGCACACGCAGAACTCGCAGGAAAACACCTCGTCCTCGGCCTCACGGGCGGCATCGCCTGCTACAAGATCGCCGAGCT
CACGCGCCTCTTGACGAAGGCGGGCGCGACCGTGCAGATCGTGATGACCGACGCCGCGACGCAGTTCATCACCCCCGTCA
CGATGCAGGCGCTGTCCGGCCGCCCCGTCTACACGAGCCAGTGGGACGCGCGGATGCCGAACAACATGGCGCACATCGAT
CTGTCGCGCGAAGCCGACGCGATCGTGATCGCGCCCGCGTCGACCGATTTCCTCGCGAAGCTCTCGCACGGCTTCGCCGA
CGATCTGCTGTCGACGCTGTGCATCGCGCGCGACTGCCCGCTCCTCGTCGTGCCGGCGATGAACCGCCAGATGTGGCAGA
ACCCGGCGACGCAGCGCAACGTCGCGCAACTGCGCCGCGACGGCGTCGCGGTGCTCGGCCCCGATTCGGGCGCGCAGGCG
TGCGGCGAGATCGGCGACGGCCGGATGCTCGAGCCGGAAGCGATCTACGAAGCGATCGTCACGCATTTCCAGCCGAAGGT
GTTCGCGCATCGCCGCGTGCTGATCACGGCCGGCCCCACCTTCGAGCCGCTCGATCCGGTTCGCGGCCTGACGAACCGCT
CGAGCGGCAAGATGGGCTTCGCGCTCGCGCGCGCCGCGCAGCAGGCGGGCGCCGACGTGCATCTCGTCGCCGGCCCCGTT
CACCTGCCGACGCCGTGGGGCGTGTACCGCGAGGACGTGCGGACCGCGCAGCAGATGTACGACGCGGTGATGAACGCGGT
GCCGGACGCGGACGTGTTCATCGCGGTCGCCGCGGTCGCCGACTGGCGCGCCGCGCAGCCCGCCGAGCACAAGATCAAGA
AGACGGCCGACCACAAGATGCCGGCGCTCACGTTCGTCGAGAACCCGGACATTCTCGCGAGCGTCGCCGCGCTGCCCGAT
GCGCCCTACTGCGTCGGCTTCGCGGCGGAAAGCGGCGATCTCGACGTGCACGGCGAGGAAAAGCGCGTGCGCAAGAAGGT
GCCGCTGCTGATCGGCAACCTCGGGCCGCTCACGTTCGGGCTCGACGACAACGAAGTCGTGCTGTTCGAAGCGTGCGGCG
CGACGCGGCTGCCGCGCGCCGACAAGATGACGCTCGCGCACGCGCTCGTCGCCGAGATCGCAAAGCGCCTGCCCGACGCG
AGCCTCATCTGA

Upstream 100 bases:

>100_bases
ATCTACGACGAGTTGCGTCGCGTGCGCGGCGCGCGCTAGGCGCATACACTTCGCGCAGGGGCCGGCGCGCGCCGGCCCCA
CGTGCTTTCGGAGGCCTCAG

Downstream 100 bases:

>100_bases
CGCGTCGCCGCGCCGCTCATCGTTCAACTCTCAACTCTCGCCACCGATTCTCGCCGCATGAAACTCGACCTGAAGATTCT
CGACGCGCGCATGCGCGACT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQIVMTDAATQFITPVTMQALSGRPVYTSQWDARMPNNMAHID
LSREADAIVIAPASTDFLAKLSHGFADDLLSTLCIARDCPLLVVPAMNRQMWQNPATQRNVAQLRRDGVAVLGPDSGAQA
CGEIGDGRMLEPEAIYEAIVTHFQPKVFAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HLPTPWGVYREDVRTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKMPALTFVENPDILASVAALPD
APYCVGFAAESGDLDVHGEEKRVRKKVPLLIGNLGPLTFGLDDNEVVLFEACGATRLPRADKMTLAHALVAEIAKRLPDA
SLI

Sequences:

>Translated_403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQIVMTDAATQFITPVTMQALSGRPVYTSQWDARMPNNMAHID
LSREADAIVIAPASTDFLAKLSHGFADDLLSTLCIARDCPLLVVPAMNRQMWQNPATQRNVAQLRRDGVAVLGPDSGAQA
CGEIGDGRMLEPEAIYEAIVTHFQPKVFAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HLPTPWGVYREDVRTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKMPALTFVENPDILASVAALPD
APYCVGFAAESGDLDVHGEEKRVRKKVPLLIGNLGPLTFGLDDNEVVLFEACGATRLPRADKMTLAHALVAEIAKRLPDA
SLI
>Mature_402_residues
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQIVMTDAATQFITPVTMQALSGRPVYTSQWDARMPNNMAHIDL
SREADAIVIAPASTDFLAKLSHGFADDLLSTLCIARDCPLLVVPAMNRQMWQNPATQRNVAQLRRDGVAVLGPDSGAQAC
GEIGDGRMLEPEAIYEAIVTHFQPKVFAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVH
LPTPWGVYREDVRTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKMPALTFVENPDILASVAALPDA
PYCVGFAAESGDLDVHGEEKRVRKKVPLLIGNLGPLTFGLDDNEVVLFEACGATRLPRADKMTLAHALVAEIAKRLPDAS
LI

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=48.7437185929648, Blast_Score=332, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=31.638418079096, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=30.6878306878307, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=31.0526315789474, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43206; Mature: 43075

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQIVMTDAATQFITPVTMQALSG
CCCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCC
RPVYTSQWDARMPNNMAHIDLSREADAIVIAPASTDFLAKLSHGFADDLLSTLCIARDCP
CCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNVAQLRRDGVAVLGPDSGAQACGEIGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHCCCCCEECHHHHHHHHH
THFQPKVFAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HHCCCCHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCE
HLPTPWGVYREDVRTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKM
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHHCCCCCCHHHHHHHHHCCCC
PALTFVENPDILASVAALPDAPYCVGFAAESGDLDVHGEEKRVRKKVPLLIGNLGPLTFG
CEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCEEEECCCCEEEC
LDDNEVVLFEACGATRLPRADKMTLAHALVAEIAKRLPDASLI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQIVMTDAATQFITPVTMQALSG
CCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCC
RPVYTSQWDARMPNNMAHIDLSREADAIVIAPASTDFLAKLSHGFADDLLSTLCIARDCP
CCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNVAQLRRDGVAVLGPDSGAQACGEIGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHCCCCCEECHHHHHHHHH
THFQPKVFAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HHCCCCHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCE
HLPTPWGVYREDVRTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKM
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHHCCCCCCHHHHHHHHHCCCC
PALTFVENPDILASVAALPDAPYCVGFAAESGDLDVHGEEKRVRKKVPLLIGNLGPLTFG
CEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCEEEECCCCEEEC
LDDNEVVLFEACGATRLPRADKMTLAHALVAEIAKRLPDASLI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]