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The map label for this gene is lrp [H]

Identifier: 83718642

GI number: 83718642

Start: 821415

End: 821918

Strand: Direct

Name: lrp [H]

Synonym: BTH_I0712

Alternate gene names: 83718642

Gene position: 821415-821918 (Clockwise)

Preceding gene: 83719097

Following gene: 83720505

Centisome position: 21.56

GC content: 64.48

Gene sequence:

>504_bases
ATGCATGCGATCACGCTGGATGCAACCGATTGCCGTATTCTCGCGGTCCTTCAGCAGGAAGGACGGATCAGCAACCTCGA
TCTGGCCGAGCGCATTTCGCTGTCGCCGTCCGCGTGCCTGCGGCGGATGCGACTCCTCGAAGAGCAGGGGGTGATCGAAC
GCTATCGCGCGTGCCTGAGCCGCGAGAAGCTCGGGTTCGAGCTGGAGGCGTTCGTGCAGGTGTCGATGCGCAACGATCAG
ACGCAGTGGCACGAGCGTTTCGCGCAAGCGGTGCGCGAATGGCCGGAGGTGGTCGGCGCGTTCGTCGTGACGGGCGAGAC
GCACTATCTGCTGCGCGTGCTCGCGCACAACCTGAAGCACTACTCCGATTTCGTGCTGAATCAGCTGTACAAGACGCCCG
GCGTGCTCGACATCCGCTCGAACATCGTGCTGCAGACGCTGAAGGACGACGTGGGGCCGCCTGTCGCGCTCGCGCGCACG
GGGCCCACGGTCAAAGCCGTGTGA

Upstream 100 bases:

>100_bases
CATGATAGGCAAACCTGCGGAGCAGGTGCTTGCGAAATAAGCATGGACAATCCACCGATATGGCAGATAATTCGAAACAG
ATCTAAAACGGAGACCAAAA

Downstream 100 bases:

>100_bases
GGCCGTGGAAGCTGCCGCTCTGGAACACGAGCGGCGCGAGCGCTGCGGCGTCGGGGTGCACGCCGCAGCGCTCGACCTCG
CCGACGAAGATCACGTGATC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MHAITLDATDCRILAVLQQEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLSREKLGFELEAFVQVSMRNDQ
TQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKHYSDFVLNQLYKTPGVLDIRSNIVLQTLKDDVGPPVALART
GPTVKAV

Sequences:

>Translated_167_residues
MHAITLDATDCRILAVLQQEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLSREKLGFELEAFVQVSMRNDQ
TQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKHYSDFVLNQLYKTPGVLDIRSNIVLQTLKDDVGPPVALART
GPTVKAV
>Mature_167_residues
MHAITLDATDCRILAVLQQEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLSREKLGFELEAFVQVSMRNDQ
TQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKHYSDFVLNQLYKTPGVLDIRSNIVLQTLKDDVGPPVALART
GPTVKAV

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787116, Length=143, Percent_Identity=36.3636363636364, Blast_Score=98, Evalue=3e-22,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18953; Mature: 18953

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAITLDATDCRILAVLQQEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLS
CCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
REKLGFELEAFVQVSMRNDQTQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKH
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
YSDFVLNQLYKTPGVLDIRSNIVLQTLKDDVGPPVALARTGPTVKAV
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MHAITLDATDCRILAVLQQEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLS
CCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
REKLGFELEAFVQVSMRNDQTQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKH
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
YSDFVLNQLYKTPGVLDIRSNIVLQTLKDDVGPPVALARTGPTVKAV
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]