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The map label for this gene is msrA [H]

Identifier: 83720505

GI number: 83720505

Start: 822489

End: 823322

Strand: Direct

Name: msrA [H]

Synonym: BTH_I0714

Alternate gene names: 83720505

Gene position: 822489-823322 (Clockwise)

Preceding gene: 83718642

Following gene: 83720758

Centisome position: 21.59

GC content: 66.43

Gene sequence:

>834_bases
ATGGCGGGAAGTGAGCAGGGCAGTCATCGGAAAATTCGTCGGGTTGGCGACGATTTTAGCGGCAATCGTGCAAGGCTGCG
ACGGACCGCCGCGCCCGGCGAGTGGCCGGCGCCACATTTTTCGCGGAACGCCGTGCGCGTCGCGATGCGGCGCGGCCGAC
GAAAAGCGCGAAGGCGGCGCGATGCGCGGACGCGGCACAAACCGTGTGCGGCGGCGGCCGGGGCAGGCGCGGCGCGCGGG
CCGCACGACGAACGTAACGAACGAAAGGAATCCGATATGAGTGAAGCAACGAACGAAATCGCGACGCTGGGCGGCGGCTG
CTTCTGGTGCCAGGAGGCGGTGTTCCTCGACGTCAACGGCGTGACGGCCGTCGAATCGGGCTACGCGGGCGGCCATACGC
GCAATCCCGGCTACCGCGACGTGTGCGACGGCGAAACGGGCCACGCGGAGGTCGTCAACGTGACGTTCGACCCGAGCCGG
ATCGGCTATCGCGAGATCGTCGAGATTTTTTTCGCGACGCACGATCCGACGCAACTGAACCGGCAGGGCAATGATGTCGG
CACGCAATACCGGTCGGTGATCTTCACGCGCTCGGATGCGCAGCGCGACGTCGCGCTCGACGTGATCCGCGCGCTCGAGC
GCGACAAGCTGTACGACGCGCCGATCGTCACGCAGGTCGAGCCGCTGAACGACAACTACTGGCCAGCGGAGGCGTATCAC
CAGAACTATTACGCGCGCAATCCGGGGCAGGGTTACTGCGCGGTCGTGATCGGCCCGAAGCTCGCGAAGTTCCGGCAGAA
GTTCGCGCATCGGCTGAAGTCGCGCGGCGCGTGA

Upstream 100 bases:

>100_bases
AAATTTGGCGGGCTGGCCTGTCCGTGTTTCATTGCGTGACGGCCTCGAGCGATGGGCGCGCGCGGCGGCGGGCGGAACGG
GCGGCGGCGCCGCGGGCGAA

Downstream 100 bases:

>100_bases
CGCGATGCGGAGACGCCCGTGTGCGTCGCGCGGCGTCCTGTTGCGTGATCGCGCGCCGGGCGGGCCTGGACGGCGCGCGT
ATCGCCCGCCGGCGGCGGGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MAGSEQGSHRKIRRVGDDFSGNRARLRRTAAPGEWPAPHFSRNAVRVAMRRGRRKARRRRDARTRHKPCAAAAGAGAARG
PHDERNERKESDMSEATNEIATLGGGCFWCQEAVFLDVNGVTAVESGYAGGHTRNPGYRDVCDGETGHAEVVNVTFDPSR
IGYREIVEIFFATHDPTQLNRQGNDVGTQYRSVIFTRSDAQRDVALDVIRALERDKLYDAPIVTQVEPLNDNYWPAEAYH
QNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA

Sequences:

>Translated_277_residues
MAGSEQGSHRKIRRVGDDFSGNRARLRRTAAPGEWPAPHFSRNAVRVAMRRGRRKARRRRDARTRHKPCAAAAGAGAARG
PHDERNERKESDMSEATNEIATLGGGCFWCQEAVFLDVNGVTAVESGYAGGHTRNPGYRDVCDGETGHAEVVNVTFDPSR
IGYREIVEIFFATHDPTQLNRQGNDVGTQYRSVIFTRSDAQRDVALDVIRALERDKLYDAPIVTQVEPLNDNYWPAEAYH
QNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
>Mature_276_residues
AGSEQGSHRKIRRVGDDFSGNRARLRRTAAPGEWPAPHFSRNAVRVAMRRGRRKARRRRDARTRHKPCAAAAGAGAARGP
HDERNERKESDMSEATNEIATLGGGCFWCQEAVFLDVNGVTAVESGYAGGHTRNPGYRDVCDGETGHAEVVNVTFDPSRI
GYREIVEIFFATHDPTQLNRQGNDVGTQYRSVIFTRSDAQRDVALDVIRALERDKLYDAPIVTQVEPLNDNYWPAEAYHQ
NYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=178, Percent_Identity=40.4494382022472, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI208609995, Length=178, Percent_Identity=40.4494382022472, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=41.7391304347826, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=43.1372549019608, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=38.7878787878788, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=187, Percent_Identity=32.0855614973262, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24664631, Length=188, Percent_Identity=31.3829787234043, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=31.055900621118, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 30955; Mature: 30824

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSEQGSHRKIRRVGDDFSGNRARLRRTAAPGEWPAPHFSRNAVRVAMRRGRRKARRRR
CCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DARTRHKPCAAAAGAGAARGPHDERNERKESDMSEATNEIATLGGGCFWCQEAVFLDVNG
HHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCC
VTAVESGYAGGHTRNPGYRDVCDGETGHAEVVNVTFDPSRIGYREIVEIFFATHDPTQLN
CEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHCCHHHHHHHHHCCCCCHHHC
RQGNDVGTQYRSVIFTRSDAQRDVALDVIRALERDKLYDAPIVTQVEPLNDNYWPAEAYH
CCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
QNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGSEQGSHRKIRRVGDDFSGNRARLRRTAAPGEWPAPHFSRNAVRVAMRRGRRKARRRR
CCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DARTRHKPCAAAAGAGAARGPHDERNERKESDMSEATNEIATLGGGCFWCQEAVFLDVNG
HHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCC
VTAVESGYAGGHTRNPGYRDVCDGETGHAEVVNVTFDPSRIGYREIVEIFFATHDPTQLN
CEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHCCHHHHHHHHHCCCCCHHHC
RQGNDVGTQYRSVIFTRSDAQRDVALDVIRALERDKLYDAPIVTQVEPLNDNYWPAEAYH
CCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
QNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]