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The map label for this gene is ubiB [H]

Identifier: 83595126

GI number: 83595126

Start: 4347212

End: 4348771

Strand: Reverse

Name: ubiB [H]

Synonym: Rru_A3797

Alternate gene names: 83595126

Gene position: 4348771-4347212 (Counterclockwise)

Preceding gene: 83595127

Following gene: 83595125

Centisome position: 99.91

GC content: 65.96

Gene sequence:

>1560_bases
ATGATTGGCCACCTCCGTAATCTGACCCGGTTGATCACCATCGCCCGGGTTCTGGCGCGTCACGATGCCCTGTTCCCGCT
GGAGCGCCTGGGGGTGGCCAAACCGGCCGTCTGGATCGCCAAGGCGGCCAGCCGCCGCAATGTGCCAGGCCGTCCGGGCG
AAAAGCTCGCCGCCGCCTTTGGCGAATTGGGTCCGTCCTTCATCAAGCTTGGCCAAGCATTGTCGACGCGGGCCGATCTG
ATGGGCGAAGAGGTCGCGGCCGACCTGTCCAATCTGCAAGACTCGCTGCCGCCCTTCCCCTTCGAGGATGTCCGCCGCAC
GGTGGAAACCGAACTGGACCGGCCCCTTGAAAGCGCCTTCAGCGTTTTCGATCCGGTGCCGGTGGCGGCGGCGTCGATCG
CCCAGGTTCATTTCGCCATCACCGCCCCCGATGCCGAGGGCCATACCCGCGAAGTCGCGGTCAAGGTTCTGCGCCCCGGC
GTCGAGGAGGCCTTCCGCCGCGATATCGATCTGCTGTTCTGGCTCTCGCGGCTGGTGGAATTCGCCCAGCCCCAGTGGCG
CCGGCTGCGCCCGGTGGAAAACGCCCGAGCCTTCGAGGAATCGGTCGTCATCGAGATGGACCTGCGCTTCGAAGCCGCCG
CCGCCTGCGAACTGGCCGAGAATTTCGCCGATGATCCGACCTTCCGCGTGCCGGCCATCGACTGGCAGCGCACCGGCCGG
CGAATCATGACCCAAGAACGGGTGCGCGGCCTGCGCATCGACGAGCCCGACAAGCTGATCGCCGCCGGCCTCGATCCCCG
GGTGCTGGTCGGCAACGCCGCCAACGCCTTCTTCAGCATGGTCTTCCGCGACGGCTTCTTCCACGCCGACCTCCACCCCG
GCAATATGTTCGTCGATGCCGAGGGGGTTCTGGTCGCCGTCGATTTCGGCATCATGGGCCGAATCGACCGCCAGACCCGG
CGCTATCTGGGCGAGATGCTGCTGGGCTTCCTGACGGGCAATTATCGCCGCGCCGCCGAGGTCCATTTCGAGGCCGGCTG
GGTTCCCGCCGATAAATCGGTCGAGGGCTTCACCCAGGCCTGCCGTTCGATCGCCGAACCGATCATGGGCCGGCCGCTCA
ACGAGATTTCCGTCGCCCGCCTGCTTGGTCAGTTGTTCCAGGTCACCGAGACCTTTGACATGCAGGCCCAGCCCCAGTTG
CTGCTTTTGCAAAAAAGCATGCTGGTGACCGAGGGCGTCGGCCGCACCCTGGCCCCCGATGTCAATATGTGGGAGCTTTC
CCGCCCGCTGATCGAATCGTGGATGGCCGACAACCTCGGTCCCCAGGCCCGGTTGGCCGATGGCATGAAGACGCTCAGCG
ACTCGGTGGGCCGGCTGCCGCGTCTGCTGGAATCGGCCGAGAACCTGCTGGGCGGCATGGATAAGGGCGGCTTCCGCCTG
CACCCGGAAACGGTCAAGGCCCTGCGCGGCAATCGCGGCCCCTTGAGCGGGGTGATCACCGTCGCCCCCTGGCTGATCGC
CATCGTGCTGGGCGTACTGCTTTTCCTCAAAGAGTCCTAA

Upstream 100 bases:

>100_bases
GAACTTCTGGCGCGCATGGAAGCCGCCGGCCTTGGTCAGGTCCGCTATCGGAACCTGTCGGGCGGCATCGCCGCCATGCA
TTCGGGACGGCGCCTCTGAC

Downstream 100 bases:

>100_bases
GCACCCCCGGGCGATCGCCGGCCCCGGCCTTGCCGCCGGGAGCGCCTCCCCAGCGCTCTGAACCAGAGTGCGACGACGAT
TTTCTTCACTCTCGAATTGC

Product: 2-octaprenylphenol hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MIGHLRNLTRLITIARVLARHDALFPLERLGVAKPAVWIAKAASRRNVPGRPGEKLAAAFGELGPSFIKLGQALSTRADL
MGEEVAADLSNLQDSLPPFPFEDVRRTVETELDRPLESAFSVFDPVPVAAASIAQVHFAITAPDAEGHTREVAVKVLRPG
VEEAFRRDIDLLFWLSRLVEFAQPQWRRLRPVENARAFEESVVIEMDLRFEAAAACELAENFADDPTFRVPAIDWQRTGR
RIMTQERVRGLRIDEPDKLIAAGLDPRVLVGNAANAFFSMVFRDGFFHADLHPGNMFVDAEGVLVAVDFGIMGRIDRQTR
RYLGEMLLGFLTGNYRRAAEVHFEAGWVPADKSVEGFTQACRSIAEPIMGRPLNEISVARLLGQLFQVTETFDMQAQPQL
LLLQKSMLVTEGVGRTLAPDVNMWELSRPLIESWMADNLGPQARLADGMKTLSDSVGRLPRLLESAENLLGGMDKGGFRL
HPETVKALRGNRGPLSGVITVAPWLIAIVLGVLLFLKES

Sequences:

>Translated_519_residues
MIGHLRNLTRLITIARVLARHDALFPLERLGVAKPAVWIAKAASRRNVPGRPGEKLAAAFGELGPSFIKLGQALSTRADL
MGEEVAADLSNLQDSLPPFPFEDVRRTVETELDRPLESAFSVFDPVPVAAASIAQVHFAITAPDAEGHTREVAVKVLRPG
VEEAFRRDIDLLFWLSRLVEFAQPQWRRLRPVENARAFEESVVIEMDLRFEAAAACELAENFADDPTFRVPAIDWQRTGR
RIMTQERVRGLRIDEPDKLIAAGLDPRVLVGNAANAFFSMVFRDGFFHADLHPGNMFVDAEGVLVAVDFGIMGRIDRQTR
RYLGEMLLGFLTGNYRRAAEVHFEAGWVPADKSVEGFTQACRSIAEPIMGRPLNEISVARLLGQLFQVTETFDMQAQPQL
LLLQKSMLVTEGVGRTLAPDVNMWELSRPLIESWMADNLGPQARLADGMKTLSDSVGRLPRLLESAENLLGGMDKGGFRL
HPETVKALRGNRGPLSGVITVAPWLIAIVLGVLLFLKES
>Mature_519_residues
MIGHLRNLTRLITIARVLARHDALFPLERLGVAKPAVWIAKAASRRNVPGRPGEKLAAAFGELGPSFIKLGQALSTRADL
MGEEVAADLSNLQDSLPPFPFEDVRRTVETELDRPLESAFSVFDPVPVAAASIAQVHFAITAPDAEGHTREVAVKVLRPG
VEEAFRRDIDLLFWLSRLVEFAQPQWRRLRPVENARAFEESVVIEMDLRFEAAAACELAENFADDPTFRVPAIDWQRTGR
RIMTQERVRGLRIDEPDKLIAAGLDPRVLVGNAANAFFSMVFRDGFFHADLHPGNMFVDAEGVLVAVDFGIMGRIDRQTR
RYLGEMLLGFLTGNYRRAAEVHFEAGWVPADKSVEGFTQACRSIAEPIMGRPLNEISVARLLGQLFQVTETFDMQAQPQL
LLLQKSMLVTEGVGRTLAPDVNMWELSRPLIESWMADNLGPQARLADGMKTLSDSVGRLPRLLESAENLLGGMDKGGFRL
HPETVKALRGNRGPLSGVITVAPWLIAIVLGVLLFLKES

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=301, Percent_Identity=25.2491694352159, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI41393593, Length=280, Percent_Identity=28.2142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI32261307, Length=322, Percent_Identity=24.5341614906832, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI217035081, Length=235, Percent_Identity=25.1063829787234, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI27363457, Length=249, Percent_Identity=26.5060240963855, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI34147522, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217416386, Length=210, Percent_Identity=28.0952380952381, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI2367309, Length=393, Percent_Identity=39.6946564885496, Blast_Score=307, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17559152, Length=305, Percent_Identity=28.8524590163934, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325148, Length=448, Percent_Identity=23.8839285714286, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323282, Length=405, Percent_Identity=23.4567901234568, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=201, Percent_Identity=29.3532338308458, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI22024280, Length=419, Percent_Identity=24.3436754176611, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24662575, Length=306, Percent_Identity=28.1045751633987, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57450; Mature: 57450

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGHLRNLTRLITIARVLARHDALFPLERLGVAKPAVWIAKAASRRNVPGRPGEKLAAAF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
GELGPSFIKLGQALSTRADLMGEEVAADLSNLQDSLPPFPFEDVRRTVETELDRPLESAF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHH
SVFDPVPVAAASIAQVHFAITAPDAEGHTREVAVKVLRPGVEEAFRRDIDLLFWLSRLVE
HHHCCCHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FAQPQWRRLRPVENARAFEESVVIEMDLRFEAAAACELAENFADDPTFRVPAIDWQRTGR
HCCCHHHHCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCHHHHCH
RIMTQERVRGLRIDEPDKLIAAGLDPRVLVGNAANAFFSMVFRDGFFHADLHPGNMFVDA
HHHHHHHHCCCCCCCCCHHHCCCCCCCEEECCHHHHHHHHHHHCCCEEEECCCCCEEEEC
EGVLVAVDFGIMGRIDRQTRRYLGEMLLGFLTGNYRRAAEVHFEAGWVPADKSVEGFTQA
CCEEEEECCCHHCCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCHHHHHHH
CRSIAEPIMGRPLNEISVARLLGQLFQVTETFDMQAQPQLLLLQKSMLVTEGVGRTLAPD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VNMWELSRPLIESWMADNLGPQARLADGMKTLSDSVGRLPRLLESAENLLGGMDKGGFRL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HPETVKALRGNRGPLSGVITVAPWLIAIVLGVLLFLKES
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIGHLRNLTRLITIARVLARHDALFPLERLGVAKPAVWIAKAASRRNVPGRPGEKLAAAF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
GELGPSFIKLGQALSTRADLMGEEVAADLSNLQDSLPPFPFEDVRRTVETELDRPLESAF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHH
SVFDPVPVAAASIAQVHFAITAPDAEGHTREVAVKVLRPGVEEAFRRDIDLLFWLSRLVE
HHHCCCHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FAQPQWRRLRPVENARAFEESVVIEMDLRFEAAAACELAENFADDPTFRVPAIDWQRTGR
HCCCHHHHCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCHHHHCH
RIMTQERVRGLRIDEPDKLIAAGLDPRVLVGNAANAFFSMVFRDGFFHADLHPGNMFVDA
HHHHHHHHCCCCCCCCCHHHCCCCCCCEEECCHHHHHHHHHHHCCCEEEECCCCCEEEEC
EGVLVAVDFGIMGRIDRQTRRYLGEMLLGFLTGNYRRAAEVHFEAGWVPADKSVEGFTQA
CCEEEEECCCHHCCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCHHHHHHH
CRSIAEPIMGRPLNEISVARLLGQLFQVTETFDMQAQPQLLLLQKSMLVTEGVGRTLAPD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VNMWELSRPLIESWMADNLGPQARLADGMKTLSDSVGRLPRLLESAENLLGGMDKGGFRL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HPETVKALRGNRGPLSGVITVAPWLIAIVLGVLLFLKES
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA