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The map label for this gene is coaBC [H]

Identifier: 83595125

GI number: 83595125

Start: 4345606

End: 4346880

Strand: Reverse

Name: coaBC [H]

Synonym: Rru_A3796

Alternate gene names: 83595125

Gene position: 4346880-4345606 (Counterclockwise)

Preceding gene: 83595126

Following gene: 83595124

Centisome position: 99.86

GC content: 70.27

Gene sequence:

>1275_bases
GTGAACGACAAGCGCATCTTGTTGATCGTGGCGGGCGGCATCGCCGCCTATAAGTCGCTCGACCTCATCCGCCGCCTGCG
CGATCAAGGGGCCCGGGTCCGCTGCGTCCTGACCCGGGGTGGCAGCCAGTTCGTCACGCAGCTGTCGCTTGCGGCGCTGT
CGGGCGAGCCGGTCTATCAGGATCTGTTCTCGCTGACTGATGAAACCGAGATGGGCCATATCCGCCTGTCGCGCGAGGCC
GATATCGTCGTGGTTGCCCCGGCGACCGCCGATCTGCTGGCCAAGATGGCCGGGGGCCATGCCGATGATCTGGCCAGCAC
CACCTTGCTCGCCACCGACAAGCCGGTTCTCGTCGCCCCGACGATGAACCTGTTCATGTGGGCCCATCCGGCGACCAGGG
CCAATATGGCCCTGCTTGAAAGCCGTGGCATCCATCGCGTCGGCCCCGGATCGGGCGATATGGCTTGCGGGGAACAGGGC
GAGGGGCGGATGGCCGAGGTGCCCGAGATCCTCGCCGCCATCAAACGGGTGCTTGGCCTGTCGCCGGCCGCGCCCGGCCC
CTTAAGCGGCCGCCACGCCCTGGTGACCAGCGGCCCCACCCACGAACCGATCGATCCGGTGCGCTATATCGCCAACCGTT
CCTCGGGCCATCAGGGCCATGCCATCGCCGGGGCCCTGGCCCGGCTTGGCGCCCGCGTCACCCTGGTCAGCGGCCCGACA
GCCCTGGCCGATCCGCCGGGAACGACGGTGGTGCGCGTCACCACGGCGCGCGAGATGCTGGCCGCCTGCCAGCAGGCCCT
GCCCGCCGATATCGCCGTCTGCGCCGCCGCCGTCGCCGATTGGACGGTGACCCATCCGGCGACCCATAAAACCAAGAAGG
CCGCCGGCGCGCCGCCGCCGGTCCTCGCCCTCAGCCCCAATCCCGATATCCTGGCCAACCTCGCCGCCGCCGGACCCCAG
CGCCCCGCCCTGGTCGTCGGCTTCGCCGCCGAGACCGAGGAGGTCGTCGCCCAGGCCTCGGCCAAGCGCCTGCGCAAGGG
CTGCGACTGGATCATCGCCAATGACGTGTCCGAGGCTGGCAATGGCGGTCGCGGCACCGTCTTCGCCAGCCCCGACAACA
CGGTGCATGTGATCACCGCCGAAGGCGTCGAAGACTGGCCGACCCTGTCCAAGGACGTGGTCGCCCACCGCTTGGCCGGG
CGCATCGCCGCGACGCTGACCGACCGGGCCGCCGCCCCCTGCCCCTCCCCCGCGCAGAAGGGATCTTTGGCATGA

Upstream 100 bases:

>100_bases
AGTCCCCTTCTAACCCTTGCGGGTGGGGGACCATCGCCAGAACCGGCGAGTCCGGCGGCCTTGTGCTGTCGCCGCCCGAC
CGCAAACGGAGCCCCATAGC

Downstream 100 bases:

>100_bases
TCAGGCTTTCCAAAAAGATGCTCTTCGCCATCGAGGCGGTGCTTGATATCGCCTATCACGCCGGCGGCGAACCGGTGCAA
AGCCGCGAGATCACCCGCCG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNDKRILLIVAGGIAAYKSLDLIRRLRDQGARVRCVLTRGGSQFVTQLSLAALSGEPVYQDLFSLTDETEMGHIRLSREA
DIVVVAPATADLLAKMAGGHADDLASTTLLATDKPVLVAPTMNLFMWAHPATRANMALLESRGIHRVGPGSGDMACGEQG
EGRMAEVPEILAAIKRVLGLSPAAPGPLSGRHALVTSGPTHEPIDPVRYIANRSSGHQGHAIAGALARLGARVTLVSGPT
ALADPPGTTVVRVTTAREMLAACQQALPADIAVCAAAVADWTVTHPATHKTKKAAGAPPPVLALSPNPDILANLAAAGPQ
RPALVVGFAAETEEVVAQASAKRLRKGCDWIIANDVSEAGNGGRGTVFASPDNTVHVITAEGVEDWPTLSKDVVAHRLAG
RIAATLTDRAAAPCPSPAQKGSLA

Sequences:

>Translated_424_residues
MNDKRILLIVAGGIAAYKSLDLIRRLRDQGARVRCVLTRGGSQFVTQLSLAALSGEPVYQDLFSLTDETEMGHIRLSREA
DIVVVAPATADLLAKMAGGHADDLASTTLLATDKPVLVAPTMNLFMWAHPATRANMALLESRGIHRVGPGSGDMACGEQG
EGRMAEVPEILAAIKRVLGLSPAAPGPLSGRHALVTSGPTHEPIDPVRYIANRSSGHQGHAIAGALARLGARVTLVSGPT
ALADPPGTTVVRVTTAREMLAACQQALPADIAVCAAAVADWTVTHPATHKTKKAAGAPPPVLALSPNPDILANLAAAGPQ
RPALVVGFAAETEEVVAQASAKRLRKGCDWIIANDVSEAGNGGRGTVFASPDNTVHVITAEGVEDWPTLSKDVVAHRLAG
RIAATLTDRAAAPCPSPAQKGSLA
>Mature_424_residues
MNDKRILLIVAGGIAAYKSLDLIRRLRDQGARVRCVLTRGGSQFVTQLSLAALSGEPVYQDLFSLTDETEMGHIRLSREA
DIVVVAPATADLLAKMAGGHADDLASTTLLATDKPVLVAPTMNLFMWAHPATRANMALLESRGIHRVGPGSGDMACGEQG
EGRMAEVPEILAAIKRVLGLSPAAPGPLSGRHALVTSGPTHEPIDPVRYIANRSSGHQGHAIAGALARLGARVTLVSGPT
ALADPPGTTVVRVTTAREMLAACQQALPADIAVCAAAVADWTVTHPATHKTKKAAGAPPPVLALSPNPDILANLAAAGPQ
RPALVVGFAAETEEVVAQASAKRLRKGCDWIIANDVSEAGNGGRGTVFASPDNTVHVITAEGVEDWPTLSKDVVAHRLAG
RIAATLTDRAAAPCPSPAQKGSLA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=34.0540540540541, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI87082301, Length=408, Percent_Identity=45.0980392156863, Blast_Score=278, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17560194, Length=178, Percent_Identity=31.4606741573034, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=31.3186813186813, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43829; Mature: 43829

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKRILLIVAGGIAAYKSLDLIRRLRDQGARVRCVLTRGGSQFVTQLSLAALSGEPVYQ
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHH
DLFSLTDETEMGHIRLSREADIVVVAPATADLLAKMAGGHADDLASTTLLATDKPVLVAP
HHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHCEEEEECCCCEEEEC
TMNLFMWAHPATRANMALLESRGIHRVGPGSGDMACGEQGEGRMAEVPEILAAIKRVLGL
CCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
SPAAPGPLSGRHALVTSGPTHEPIDPVRYIANRSSGHQGHAIAGALARLGARVTLVSGPT
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCC
ALADPPGTTVVRVTTAREMLAACQQALPADIAVCAAAVADWTVTHPATHKTKKAAGAPPP
CCCCCCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCHHHCCCCCCC
VLALSPNPDILANLAAAGPQRPALVVGFAAETEEVVAQASAKRLRKGCDWIIANDVSEAG
EEEECCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCHHHCC
NGGRGTVFASPDNTVHVITAEGVEDWPTLSKDVVAHRLAGRIAATLTDRAAAPCPSPAQK
CCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GSLA
CCCC
>Mature Secondary Structure
MNDKRILLIVAGGIAAYKSLDLIRRLRDQGARVRCVLTRGGSQFVTQLSLAALSGEPVYQ
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHH
DLFSLTDETEMGHIRLSREADIVVVAPATADLLAKMAGGHADDLASTTLLATDKPVLVAP
HHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHCEEEEECCCCEEEEC
TMNLFMWAHPATRANMALLESRGIHRVGPGSGDMACGEQGEGRMAEVPEILAAIKRVLGL
CCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
SPAAPGPLSGRHALVTSGPTHEPIDPVRYIANRSSGHQGHAIAGALARLGARVTLVSGPT
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCC
ALADPPGTTVVRVTTAREMLAACQQALPADIAVCAAAVADWTVTHPATHKTKKAAGAPPP
CCCCCCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCHHHCCCCCCC
VLALSPNPDILANLAAAGPQRPALVVGFAAETEEVVAQASAKRLRKGCDWIIANDVSEAG
EEEECCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCHHHCC
NGGRGTVFASPDNTVHVITAEGVEDWPTLSKDVVAHRLAGRIAATLTDRAAAPCPSPAQK
CCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GSLA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA