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The map label for this gene is ubiE [H]

Identifier: 83595127

GI number: 83595127

Start: 4348773

End: 4349585

Strand: Reverse

Name: ubiE [H]

Synonym: Rru_A3798

Alternate gene names: 83595127

Gene position: 4349585-4348773 (Counterclockwise)

Preceding gene: NA

Following gene: 83595126

Centisome position: 99.93

GC content: 64.7

Gene sequence:

>813_bases
GTGTGGCGTGGCCCCGTCGCTTATACTAAGGTGCGCGGCATGACGCAGGAAACTGATACGACACACTTTGGCTTCCGTAC
CGTCAAGGCGGCGGAAAAGGCCAGTCTCGTGCGCGGAGTCTTCGACTCCGTCGCTCCCCGCTACGACCTGATGAACGACC
TGATGAGCGGTGGCATTCACCGGGTCTGGAAGGACGCCTTCGTCGATTGGCTCGATCCCCGCCCGGGGCGCGCCTATCTC
GACTTGGCCGGCGGCACCGGCGATATCGCCTTCCGCATTCTGGAACGCAGCCGCCGCAAAGTGGCCGAGGGCGTCGCCCC
GGCCCATGTGACGGTTTGCGACATCAACAAGGAAATGCTCAGCGTCGGCCGTGATCGCGCGATCGATCGCGGCATCGTCA
GCGGCCTGTCATGGACCTGCGGCGACGCCGAGGCCGTTCCCTTGCCCGACCGCAGCGTCGATGCCTATACCATCGCCTTC
GGCCTGCGCAACGTCACCCATATCGACGCCGCCCTGGCCGAGGCGCGGCGCGTGCTCAAGCCCGGCGGCCGTTTCCTGTG
CCTGGAATTCAGCAAGGTGGTGGTGCCGGTCCTTGACCAGCTTTACGACCTTTATTCCTTCAAGATGTTGCCGATCATGG
GCCGCTACGTCGCCCGTGACGAGGAAGCCTATCGCTATCTGGCCGAGAGCATCCGCAAGTTCCCGCCCCAGGAAGAACTT
CTGGCGCGCATGGAAGCCGCCGGCCTTGGTCAGGTCCGCTATCGGAACCTGTCGGGCGGCATCGCCGCCATGCATTCGGG
ACGGCGCCTCTGA

Upstream 100 bases:

>100_bases
GGTTTCCACTTCGGGTAATTCTGGCATATGGTCCGCTTCCCTTGGGGTTCCCCGCCAAGATGGCGCGGGACGCACCCCGT
TCTCCGGGGCGCCAACGTTC

Downstream 100 bases:

>100_bases
CATGATTGGCCACCTCCGTAATCTGACCCGGTTGATCACCATCGCCCGGGTTCTGGCGCGTCACGATGCCCTGTTCCCGC
TGGAGCGCCTGGGGGTGGCC

Product: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MWRGPVAYTKVRGMTQETDTTHFGFRTVKAAEKASLVRGVFDSVAPRYDLMNDLMSGGIHRVWKDAFVDWLDPRPGRAYL
DLAGGTGDIAFRILERSRRKVAEGVAPAHVTVCDINKEMLSVGRDRAIDRGIVSGLSWTCGDAEAVPLPDRSVDAYTIAF
GLRNVTHIDAALAEARRVLKPGGRFLCLEFSKVVVPVLDQLYDLYSFKMLPIMGRYVARDEEAYRYLAESIRKFPPQEEL
LARMEAAGLGQVRYRNLSGGIAAMHSGRRL

Sequences:

>Translated_270_residues
MWRGPVAYTKVRGMTQETDTTHFGFRTVKAAEKASLVRGVFDSVAPRYDLMNDLMSGGIHRVWKDAFVDWLDPRPGRAYL
DLAGGTGDIAFRILERSRRKVAEGVAPAHVTVCDINKEMLSVGRDRAIDRGIVSGLSWTCGDAEAVPLPDRSVDAYTIAF
GLRNVTHIDAALAEARRVLKPGGRFLCLEFSKVVVPVLDQLYDLYSFKMLPIMGRYVARDEEAYRYLAESIRKFPPQEEL
LARMEAAGLGQVRYRNLSGGIAAMHSGRRL
>Mature_270_residues
MWRGPVAYTKVRGMTQETDTTHFGFRTVKAAEKASLVRGVFDSVAPRYDLMNDLMSGGIHRVWKDAFVDWLDPRPGRAYL
DLAGGTGDIAFRILERSRRKVAEGVAPAHVTVCDINKEMLSVGRDRAIDRGIVSGLSWTCGDAEAVPLPDRSVDAYTIAF
GLRNVTHIDAALAEARRVLKPGGRFLCLEFSKVVVPVLDQLYDLYSFKMLPIMGRYVARDEEAYRYLAESIRKFPPQEEL
LARMEAAGLGQVRYRNLSGGIAAMHSGRRL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=295, Percent_Identity=48.4745762711864, Blast_Score=287, Evalue=8e-78,
Organism=Escherichia coli, GI48994983, Length=255, Percent_Identity=48.2352941176471, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17557039, Length=251, Percent_Identity=47.4103585657371, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=264, Percent_Identity=43.5606060606061, Blast_Score=208, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24641702, Length=257, Percent_Identity=52.1400778210117, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30110; Mature: 30110

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRGPVAYTKVRGMTQETDTTHFGFRTVKAAEKASLVRGVFDSVAPRYDLMNDLMSGGIH
CCCCCCHHHHHCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHH
RVWKDAFVDWLDPRPGRAYLDLAGGTGDIAFRILERSRRKVAEGVAPAHVTVCDINKEML
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
SVGRDRAIDRGIVSGLSWTCGDAEAVPLPDRSVDAYTIAFGLRNVTHIDAALAEARRVLK
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
PGGRFLCLEFSKVVVPVLDQLYDLYSFKMLPIMGRYVARDEEAYRYLAESIRKFPPQEEL
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
LARMEAAGLGQVRYRNLSGGIAAMHSGRRL
HHHHHHCCCCCEEEECCCCCHHHHCCCCCC
>Mature Secondary Structure
MWRGPVAYTKVRGMTQETDTTHFGFRTVKAAEKASLVRGVFDSVAPRYDLMNDLMSGGIH
CCCCCCHHHHHCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHH
RVWKDAFVDWLDPRPGRAYLDLAGGTGDIAFRILERSRRKVAEGVAPAHVTVCDINKEML
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
SVGRDRAIDRGIVSGLSWTCGDAEAVPLPDRSVDAYTIAFGLRNVTHIDAALAEARRVLK
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
PGGRFLCLEFSKVVVPVLDQLYDLYSFKMLPIMGRYVARDEEAYRYLAESIRKFPPQEEL
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
LARMEAAGLGQVRYRNLSGGIAAMHSGRRL
HHHHHHCCCCCEEEECCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA