Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 83594966

GI number: 83594966

Start: 4178175

End: 4179329

Strand: Reverse

Name: ribA [H]

Synonym: Rru_A3637

Alternate gene names: 83594966

Gene position: 4179329-4178175 (Counterclockwise)

Preceding gene: 83594968

Following gene: 83594965

Centisome position: 96.01

GC content: 69.52

Gene sequence:

>1155_bases
GTGACCGATAACGCCCCTTGCGTCCCCTTCGCCTCCGCCGCCGCCGATCCGCTCGCCGACACCGGCCGATTGCTCGCCCG
CGTCGACCGGGGATTGGCCGAATTGCGCCTGGGCGCGGCGGTGACGATTACCGGCGATGACGGCCGATTGATGGCGCTGG
CGGCGGAATCCGCCTCGGCGCAGACCCTGGCCGATCTGGCCGCCCTCGGCCCTTCGCCCAGGGTGATTCTGACCGGCCGG
CGGGCCTCGGTGCTCGGTCTGGCGCCGGCGGCGACAACGCCGGTGGCCGTCACCCTGAAGGGCGGGCTGGACGTTGGAGC
GATTTGCCGGCTGGCCGATCCCTGCCTTGATCTGGACGGGCCCTTGCCGGCGATCGCCGCCGTCGACCCGATCGCCGGCG
ATGGATCGGCCGGAGCGGCGGTGGTTCTGGCCAAGCTGGCCCGCCTGTTGCCCGCCGCCGTGGTGGTCGCCCTGGAGGGC
GCCGGCCCGCCGGCGACCGACCCCGCCGCCCCCCTCGCCTTCGCTCTGGCCGCCACGGATATCTTGCGTTACCAGACCGC
CGCCGCCCGGTCGCTGCGCAAGGTGAGCGAGGCGCGGGTTCCCTTGGCCGGGGCCGAGCACACCCGCATCCTGGCCTTCC
GCCCTTCGGACGGCGGAACCGAGCATCTGGCGATCATCGTCGGCGAGCCCGATTCCTTGCAGCCGGTTCTCACCCGCCTG
CATTCCGAATGTTTCACCGGCGATCTTCTGGGGTCGCTGCGCTGCGATTGCGGCGACCAGCTGCGCGGTGCCCTTGACGC
CATCGCCGCGGAGGGCAGCGGCGTGCTGCTGTATCTGGCCCAGGAAGGCCGGGGCATCGGGCTGGTCAACAAGCTGCGCG
CCTATCAGCTGCAAGACCAGGGCTTTGATACCCTTGATGCCAATGGCCAGCTTGGCTTCGATGACGACGAGCGCATCTAT
CTGCCCGCCGCCGAGATCCTGCGCCAGCTTGGCATTTCGCGGGTCCGGCTTCTGACCAATAATCCGCTGAAGGTCGAGGC
GCTTGGCCGCCACGCCATCACCGTGGTCGAGCGCGTTCCCCATATCTATGAACCCAACCCCTATAACCTGCGCTACCTGC
AGACCAAGGCCCGGCGCAGCGGTCATCTGTTTTAG

Upstream 100 bases:

>100_bases
GGCCTTTCCATAGCCCCCCTCCCCGCCCTATCTATGAGCCGGCCCCCGACCCGGCGCCTTTTTCCGGCGCGGCTTTTCGC
ACCCAAGTTGGACAGGTTCC

Downstream 100 bases:

>100_bases
GGGGGTGTTTTAGGGCGGATGTTTTGGGGTGGGCGCCGGTCGTTCCTGCCCCTTGCGCCGGCCCGGATCGGCATATCCTG
CCCACCTCGGGGTTTTTTCC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTDNAPCVPFASAAADPLADTGRLLARVDRGLAELRLGAAVTITGDDGRLMALAAESASAQTLADLAALGPSPRVILTGR
RASVLGLAPAATTPVAVTLKGGLDVGAICRLADPCLDLDGPLPAIAAVDPIAGDGSAGAAVVLAKLARLLPAAVVVALEG
AGPPATDPAAPLAFALAATDILRYQTAAARSLRKVSEARVPLAGAEHTRILAFRPSDGGTEHLAIIVGEPDSLQPVLTRL
HSECFTGDLLGSLRCDCGDQLRGALDAIAAEGSGVLLYLAQEGRGIGLVNKLRAYQLQDQGFDTLDANGQLGFDDDERIY
LPAAEILRQLGISRVRLLTNNPLKVEALGRHAITVVERVPHIYEPNPYNLRYLQTKARRSGHLF

Sequences:

>Translated_384_residues
MTDNAPCVPFASAAADPLADTGRLLARVDRGLAELRLGAAVTITGDDGRLMALAAESASAQTLADLAALGPSPRVILTGR
RASVLGLAPAATTPVAVTLKGGLDVGAICRLADPCLDLDGPLPAIAAVDPIAGDGSAGAAVVLAKLARLLPAAVVVALEG
AGPPATDPAAPLAFALAATDILRYQTAAARSLRKVSEARVPLAGAEHTRILAFRPSDGGTEHLAIIVGEPDSLQPVLTRL
HSECFTGDLLGSLRCDCGDQLRGALDAIAAEGSGVLLYLAQEGRGIGLVNKLRAYQLQDQGFDTLDANGQLGFDDDERIY
LPAAEILRQLGISRVRLLTNNPLKVEALGRHAITVVERVPHIYEPNPYNLRYLQTKARRSGHLF
>Mature_383_residues
TDNAPCVPFASAAADPLADTGRLLARVDRGLAELRLGAAVTITGDDGRLMALAAESASAQTLADLAALGPSPRVILTGRR
ASVLGLAPAATTPVAVTLKGGLDVGAICRLADPCLDLDGPLPAIAAVDPIAGDGSAGAAVVLAKLARLLPAAVVVALEGA
GPPATDPAAPLAFALAATDILRYQTAAARSLRKVSEARVPLAGAEHTRILAFRPSDGGTEHLAIIVGEPDSLQPVLTRLH
SECFTGDLLGSLRCDCGDQLRGALDAIAAEGSGVLLYLAQEGRGIGLVNKLRAYQLQDQGFDTLDANGQLGFDDDERIYL
PAAEILRQLGISRVRLLTNNPLKVEALGRHAITVVERVPHIYEPNPYNLRYLQTKARRSGHLF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=52.5773195876289, Blast_Score=201, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6319438, Length=196, Percent_Identity=42.8571428571429, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 39884; Mature: 39753

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNAPCVPFASAAADPLADTGRLLARVDRGLAELRLGAAVTITGDDGRLMALAAESASA
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHHCCCEEEEEECCCCEEEEEEECCCCH
QTLADLAALGPSPRVILTGRRASVLGLAPAATTPVAVTLKGGLDVGAICRLADPCLDLDG
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCC
PLPAIAAVDPIAGDGSAGAAVVLAKLARLLPAAVVVALEGAGPPATDPAAPLAFALAATD
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHH
ILRYQTAAARSLRKVSEARVPLAGAEHTRILAFRPSDGGTEHLAIIVGEPDSLQPVLTRL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHH
HSECFTGDLLGSLRCDCGDQLRGALDAIAAEGSGVLLYLAQEGRGIGLVNKLRAYQLQDQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHEECCC
GFDTLDANGQLGFDDDERIYLPAAEILRQLGISRVRLLTNNPLKVEALGRHAITVVERVP
CCCEECCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHCC
HIYEPNPYNLRYLQTKARRSGHLF
CCCCCCCCCEEEEEEHHHHCCCCC
>Mature Secondary Structure 
TDNAPCVPFASAAADPLADTGRLLARVDRGLAELRLGAAVTITGDDGRLMALAAESASA
CCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHHCCCEEEEEECCCCEEEEEEECCCCH
QTLADLAALGPSPRVILTGRRASVLGLAPAATTPVAVTLKGGLDVGAICRLADPCLDLDG
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCC
PLPAIAAVDPIAGDGSAGAAVVLAKLARLLPAAVVVALEGAGPPATDPAAPLAFALAATD
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHH
ILRYQTAAARSLRKVSEARVPLAGAEHTRILAFRPSDGGTEHLAIIVGEPDSLQPVLTRL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHH
HSECFTGDLLGSLRCDCGDQLRGALDAIAAEGSGVLLYLAQEGRGIGLVNKLRAYQLQDQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHEECCC
GFDTLDANGQLGFDDDERIYLPAAEILRQLGISRVRLLTNNPLKVEALGRHAITVVERVP
CCCEECCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHCC
HIYEPNPYNLRYLQTKARRSGHLF
CCCCCCCCCEEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]