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The map label for this gene is hemE

Identifier: 83594945

GI number: 83594945

Start: 4154681

End: 4155727

Strand: Direct

Name: hemE

Synonym: Rru_A3616

Alternate gene names: 83594945

Gene position: 4154681-4155727 (Clockwise)

Preceding gene: 83594939

Following gene: 83594946

Centisome position: 95.45

GC content: 63.71

Gene sequence:

>1047_bases
GTGAGCGTGCCGTCCAAGACCCAAAAGCCCTTTCTCCAAGCCCTGGCCGGCGAAACCCTGAGTCCGCCGCCGGTATGGTT
GATGCGTCAGGCTGGACGCTACCTTCCCGAGTATCGGGCGACCCGGGAAGAGGCCGGTGGGTTCCTCGATCTGTGCTACA
CCCCGAAGTTGGCGGTGGAGGTCACCCTGCAGCCGCTGCGCCGTTACGCCTTCGACGCGGCGATCTTGTTTTCCGATATT
CTGGTGGTGCCCAACGCCATCGGTCGGCAGGTCGCTTTCAAGCAAGGCGAGGGACCGGTTCTTGATCCGCTGACCAGCCG
TGCCGATGTCGAGGCGCTTGAGCCCGGAAAACTGCGCGAGCGTCTGGGGCCGGTGTTTGAGACCGTGCGGGGTCTGGCGA
GCGCCATTCCGTCGACGACGGCGCTGATCGGTTTCGCCGGCGCGCCGTGGACGGTGGCGACCTATATGCTCGAAGGCGGG
TCGAGTAAGGATTTCTCGGTGGCCAAATCGTGGATCTACAGCCGTCCCGATGATTTCGCCGCCCTGATGGAGGTGCTGAT
CAGCGCCACCACCGATTATCTGATCGCCCAGATCGACGCCGGCGCCGAAGCCATCCAGATTTTCGACACCTGGGCCGGCG
TTCTGCCGGAAACGGAATTCCATCGCTGGGTGATCGAGCCGATCGGCCGGATCACCCGCGCCCTTCACGAACAGCGCCCC
GGGGTTCCGGTGATCGGTTTTCCCAAAGGCGCCGGGGTTCTTTACGAGACCTTCATCCGGGAAACCGGCGTGGACGGCGT
TGGGCTCGACGCCTCGGTTCCTTTGGCCTGGGCGGCCAAGACCCTGCAGCCGCTGTGCACCGTGCAGGGCAACATGGATC
CCTTGCTGCTGGTCGAGGGCGGTCCGCTGATGGAACAGGCGGTCAAGCGCCTTCTTGATACCCTTGGCCATGGACCCTTT
ATCTTCAATCTCGGGCATGGCATTGTGCCGCAGACCCCTCCCGAGAATGTTGCTCGCCTGATCGACTTGGTTCGCGCGCC
GCGTTAG

Upstream 100 bases:

>100_bases
CCACCTTTTCTTTTCTTTTCCTTTTATATTATGCAGGACCGACTGAACCGGATGGCGCCAGCCGCCGGGGAACCGACAAT
GCCAACAGGGGAGTGAACCC

Downstream 100 bases:

>100_bases
AACATTTCTGATCAAGCCCGGTAGGGCCTCGGGTCCGAGAGGTATATCGGTCGTTTTCCAGCCCCTGGGGGGCTGGAAGG
CGGCCGTCTTGGACCCTTTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSVPSKTQKPFLQALAGETLSPPPVWLMRQAGRYLPEYRATREEAGGFLDLCYTPKLAVEVTLQPLRRYAFDAAILFSDI
LVVPNAIGRQVAFKQGEGPVLDPLTSRADVEALEPGKLRERLGPVFETVRGLASAIPSTTALIGFAGAPWTVATYMLEGG
SSKDFSVAKSWIYSRPDDFAALMEVLISATTDYLIAQIDAGAEAIQIFDTWAGVLPETEFHRWVIEPIGRITRALHEQRP
GVPVIGFPKGAGVLYETFIRETGVDGVGLDASVPLAWAAKTLQPLCTVQGNMDPLLLVEGGPLMEQAVKRLLDTLGHGPF
IFNLGHGIVPQTPPENVARLIDLVRAPR

Sequences:

>Translated_348_residues
MSVPSKTQKPFLQALAGETLSPPPVWLMRQAGRYLPEYRATREEAGGFLDLCYTPKLAVEVTLQPLRRYAFDAAILFSDI
LVVPNAIGRQVAFKQGEGPVLDPLTSRADVEALEPGKLRERLGPVFETVRGLASAIPSTTALIGFAGAPWTVATYMLEGG
SSKDFSVAKSWIYSRPDDFAALMEVLISATTDYLIAQIDAGAEAIQIFDTWAGVLPETEFHRWVIEPIGRITRALHEQRP
GVPVIGFPKGAGVLYETFIRETGVDGVGLDASVPLAWAAKTLQPLCTVQGNMDPLLLVEGGPLMEQAVKRLLDTLGHGPF
IFNLGHGIVPQTPPENVARLIDLVRAPR
>Mature_347_residues
SVPSKTQKPFLQALAGETLSPPPVWLMRQAGRYLPEYRATREEAGGFLDLCYTPKLAVEVTLQPLRRYAFDAAILFSDIL
VVPNAIGRQVAFKQGEGPVLDPLTSRADVEALEPGKLRERLGPVFETVRGLASAIPSTTALIGFAGAPWTVATYMLEGGS
SKDFSVAKSWIYSRPDDFAALMEVLISATTDYLIAQIDAGAEAIQIFDTWAGVLPETEFHRWVIEPIGRITRALHEQRPG
VPVIGFPKGAGVLYETFIRETGVDGVGLDASVPLAWAAKTLQPLCTVQGNMDPLLLVEGGPLMEQAVKRLLDTLGHGPFI
FNLGHGIVPQTPPENVARLIDLVRAPR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=40.4011461318052, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI2367337, Length=339, Percent_Identity=45.7227138643068, Blast_Score=281, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=32.7683615819209, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI221330099, Length=349, Percent_Identity=39.2550143266476, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI19921920, Length=355, Percent_Identity=39.4366197183099, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RHORT (Q2RN85)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428697.1
- ProteinModelPortal:   Q2RN85
- SMR:   Q2RN85
- STRING:   Q2RN85
- GeneID:   3837072
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3616
- NMPDR:   fig|1085.1.peg.1300
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q2RN85
- ProtClustDB:   PRK00115
- BioCyc:   RRUB269796:RRU_A3616-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37764; Mature: 37633

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 79-79 BINDING 155-155 BINDING 210-210 BINDING 326-326

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPSKTQKPFLQALAGETLSPPPVWLMRQAGRYLPEYRATREEAGGFLDLCYTPKLAVE
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCEEEE
VTLQPLRRYAFDAAILFSDILVVPNAIGRQVAFKQGEGPVLDPLTSRADVEALEPGKLRE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
RLGPVFETVRGLASAIPSTTALIGFAGAPWTVATYMLEGGSSKDFSVAKSWIYSRPDDFA
HHHHHHHHHHHHHHHCCCHHHHEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
ALMEVLISATTDYLIAQIDAGAEAIQIFDTWAGVLPETEFHRWVIEPIGRITRALHEQRP
HHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
GVPVIGFPKGAGVLYETFIRETGVDGVGLDASVPLAWAAKTLQPLCTVQGNMDPLLLVEG
CCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
GPLMEQAVKRLLDTLGHGPFIFNLGHGIVPQTPPENVARLIDLVRAPR
CHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVPSKTQKPFLQALAGETLSPPPVWLMRQAGRYLPEYRATREEAGGFLDLCYTPKLAVE
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCEEEE
VTLQPLRRYAFDAAILFSDILVVPNAIGRQVAFKQGEGPVLDPLTSRADVEALEPGKLRE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
RLGPVFETVRGLASAIPSTTALIGFAGAPWTVATYMLEGGSSKDFSVAKSWIYSRPDDFA
HHHHHHHHHHHHHHHCCCHHHHEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
ALMEVLISATTDYLIAQIDAGAEAIQIFDTWAGVLPETEFHRWVIEPIGRITRALHEQRP
HHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
GVPVIGFPKGAGVLYETFIRETGVDGVGLDASVPLAWAAKTLQPLCTVQGNMDPLLLVEG
CCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
GPLMEQAVKRLLDTLGHGPFIFNLGHGIVPQTPPENVARLIDLVRAPR
CHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA