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The map label for this gene is hemH [H]

Identifier: 83594946

GI number: 83594946

Start: 4155853

End: 4156941

Strand: Direct

Name: hemH [H]

Synonym: Rru_A3617

Alternate gene names: 83594946

Gene position: 4155853-4156941 (Clockwise)

Preceding gene: 83594945

Following gene: 83594947

Centisome position: 95.47

GC content: 66.48

Gene sequence:

>1089_bases
ATGGCCCGTATCGCCGTCGTCCTGTTCAATCTGGGCGGACCGGACAGTCCTGAAGCCGTGCGGCCGTTTCTGTTCAATCT
TTTCAACGACCCCGCGATCATCGAGGGGCCGAGCCTGACCCGTTGGGTGCTCGCCCGGCTGATTTCCTGGCGGCGAGCGC
CGATCGCCCGCGAGATCTACGGTCATCTCGGCGGACGCTCGCCCCTGCTCGAACAGACCGAGGGCCAGGCGAGAGCCCTG
GAAAAGGCCCTGAGCGAGCGCGGACATGACGCCCGTTGCCTGATCGCCATGCGCTACTGGAAGCCTTTGACCCGCGAAGC
GGTCAAGGCGGCCAAGGCGTGGAACCCCGATCAGGTGGTGTTATTGCCGCTCTATCCGCAGTTTTCGGGCACCACCTCGG
GATCGTCGTTGAACCAATGGACGGTCGAGGCCGAGAAGGCCGGGCTGACGGCGCAGACCCATACGGTATGTTGTTACGCC
ACCGAGGTCGGCTTGATCACCGCCCTGGCCGAACGCACCCTGGGGGGTCTGGAGCAGGTGCGCGAAAGCACCGTTGGTCT
GCCGGCGCCCCGGGTGCTGTTCTCCGCCCATGGGCTGCCCCGCAAGGTGGTGGATGCCGGTGACCCCTACCAATCCCACG
TCGAGGCGACCGTGAACGCCGTGGTGGCCGCCATGGCCGTGGAGGGCCTGGATTACCAGGTCTGCTATCAAAGCCGGGTG
GGGCCGCTGGAATGGATCGGCCCCAGCACCGAAGACGAGATCGCCAAGGCCGGACGCGAGGGGCGGCCGCTGGTGGTGGT
GCCGGTGGCCTTTGTTTCGGAGCATTCGGAAACCCTGGTCGAGCTTGATATCGAATACGGCGAGCTGGCCGAGGAGCGGG
GCGTGCCCAAATACGTGCGCGTACCCACGGTGCGCGAGCATCCGGCCTTCATCGGCGGTCTGGCCGGGCTGGTCGAACGG
GCCATGCGCAGCGATGGCCGGCCCTGTTCCCACCTCAATCGCCGGGTTTGCGAAGGACGCTGGGGGCGGTGTCTGCACCT
TTCCTCGCGCAAAGCCGAGGCCCAGTCGCGCGGCGGCGACACAAAATAG

Upstream 100 bases:

>100_bases
GCCTCGGGTCCGAGAGGTATATCGGTCGTTTTCCAGCCCCTGGGGGGCTGGAAGGCGGCCGTCTTGGACCCTTTTCGCTT
TTGGCCTTGAAAGGTTTGGC

Downstream 100 bases:

>100_bases
ACGCGGTTCCTGGCCGGGGGTCCGCCAAAAGGCTTGACGACCTGTCGTGGTGTCGCGGACACCTTGACGAGGGTTGGCGC
CGCCAGAGGGGATCAACGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MARIAVVLFNLGGPDSPEAVRPFLFNLFNDPAIIEGPSLTRWVLARLISWRRAPIAREIYGHLGGRSPLLEQTEGQARAL
EKALSERGHDARCLIAMRYWKPLTREAVKAAKAWNPDQVVLLPLYPQFSGTTSGSSLNQWTVEAEKAGLTAQTHTVCCYA
TEVGLITALAERTLGGLEQVRESTVGLPAPRVLFSAHGLPRKVVDAGDPYQSHVEATVNAVVAAMAVEGLDYQVCYQSRV
GPLEWIGPSTEDEIAKAGREGRPLVVVPVAFVSEHSETLVELDIEYGELAEERGVPKYVRVPTVREHPAFIGGLAGLVER
AMRSDGRPCSHLNRRVCEGRWGRCLHLSSRKAEAQSRGGDTK

Sequences:

>Translated_362_residues
MARIAVVLFNLGGPDSPEAVRPFLFNLFNDPAIIEGPSLTRWVLARLISWRRAPIAREIYGHLGGRSPLLEQTEGQARAL
EKALSERGHDARCLIAMRYWKPLTREAVKAAKAWNPDQVVLLPLYPQFSGTTSGSSLNQWTVEAEKAGLTAQTHTVCCYA
TEVGLITALAERTLGGLEQVRESTVGLPAPRVLFSAHGLPRKVVDAGDPYQSHVEATVNAVVAAMAVEGLDYQVCYQSRV
GPLEWIGPSTEDEIAKAGREGRPLVVVPVAFVSEHSETLVELDIEYGELAEERGVPKYVRVPTVREHPAFIGGLAGLVER
AMRSDGRPCSHLNRRVCEGRWGRCLHLSSRKAEAQSRGGDTK
>Mature_361_residues
ARIAVVLFNLGGPDSPEAVRPFLFNLFNDPAIIEGPSLTRWVLARLISWRRAPIAREIYGHLGGRSPLLEQTEGQARALE
KALSERGHDARCLIAMRYWKPLTREAVKAAKAWNPDQVVLLPLYPQFSGTTSGSSLNQWTVEAEKAGLTAQTHTVCCYAT
EVGLITALAERTLGGLEQVRESTVGLPAPRVLFSAHGLPRKVVDAGDPYQSHVEATVNAVVAAMAVEGLDYQVCYQSRVG
PLEWIGPSTEDEIAKAGREGRPLVVVPVAFVSEHSETLVELDIEYGELAEERGVPKYVRVPTVREHPAFIGGLAGLVERA
MRSDGRPCSHLNRRVCEGRWGRCLHLSSRKAEAQSRGGDTK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=34.7305389221557, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=34.7305389221557, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786681, Length=323, Percent_Identity=28.4829721362229, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324750, Length=329, Percent_Identity=32.2188449848024, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=34.0425531914894, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=31.1284046692607, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45552018, Length=168, Percent_Identity=39.2857142857143, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39601; Mature: 39469

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIAVVLFNLGGPDSPEAVRPFLFNLFNDPAIIEGPSLTRWVLARLISWRRAPIAREIY
CCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHH
GHLGGRSPLLEQTEGQARALEKALSERGHDARCLIAMRYWKPLTREAVKAAKAWNPDQVV
HHCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCCCCEE
LLPLYPQFSGTTSGSSLNQWTVEAEKAGLTAQTHTVCCYATEVGLITALAERTLGGLEQV
EEECCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
RESTVGLPAPRVLFSAHGLPRKVVDAGDPYQSHVEATVNAVVAAMAVEGLDYQVCYQSRV
HHHHCCCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCC
GPLEWIGPSTEDEIAKAGREGRPLVVVPVAFVSEHSETLVELDIEYGELAEERGVPKYVR
CCEEECCCCCHHHHHHCCCCCCCEEEEEHHHHCCCCCEEEEEECCHHHHHHHCCCCCEEE
VPTVREHPAFIGGLAGLVERAMRSDGRPCSHLNRRVCEGRWGRCLHLSSRKAEAQSRGGD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCC
TK
CC
>Mature Secondary Structure 
ARIAVVLFNLGGPDSPEAVRPFLFNLFNDPAIIEGPSLTRWVLARLISWRRAPIAREIY
CEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHH
GHLGGRSPLLEQTEGQARALEKALSERGHDARCLIAMRYWKPLTREAVKAAKAWNPDQVV
HHCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCCCCEE
LLPLYPQFSGTTSGSSLNQWTVEAEKAGLTAQTHTVCCYATEVGLITALAERTLGGLEQV
EEECCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
RESTVGLPAPRVLFSAHGLPRKVVDAGDPYQSHVEATVNAVVAAMAVEGLDYQVCYQSRV
HHHHCCCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCC
GPLEWIGPSTEDEIAKAGREGRPLVVVPVAFVSEHSETLVELDIEYGELAEERGVPKYVR
CCEEECCCCCHHHHHHCCCCCCCEEEEEHHHHCCCCCEEEEEECCHHHHHHHCCCCCEEE
VPTVREHPAFIGGLAGLVERAMRSDGRPCSHLNRRVCEGRWGRCLHLSSRKAEAQSRGGD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCC
TK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA