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The map label for this gene is phoR [H]

Identifier: 83594872

GI number: 83594872

Start: 4079235

End: 4080671

Strand: Direct

Name: phoR [H]

Synonym: Rru_A3543

Alternate gene names: 83594872

Gene position: 4079235-4080671 (Clockwise)

Preceding gene: 83594871

Following gene: 83594873

Centisome position: 93.71

GC content: 70.01

Gene sequence:

>1437_bases
ATGGACCGCCTGACCCCCTCGCTCGGCCGATTGATCGGGGCGGCGATGCTGGTCTGCGTTCCGGCCACGGCGGTGCTTCT
CGGGCTGACGCTTTGGGGGCGGCTCAGCGTCGGCGTCGCCCTGGTGGCGGGCGTTCTGATCTGGACCCTCACCGCCTTGC
TGCTGCGCTCAATCCTGCGCGAGTTCATGGTGGTCTCGCGCCATATCCGCGGCCTGGGCGGCCGCTCGGAGGCGGGCGAG
GGTGCCGCGCCGACGCCGCGCCTGGAGATCGCCCAGGGCCTGCTGGGCGCCGCCCAGCATCTCGATCGCGGCTGGCGCCG
GCGCACCCAAGCCTTGCGCGACCAGTTGCGCTCGGATGAACAGGTGCTCAACACCCTGCCCGATCCCTTGTTGATGATCG
CCAAGGAAGCGGTGGTCACCCGGGCCAACGAGGCGGCGCGCAGCCTGTTTGGCCGTGACCCGGCGGGGCAGGAGATCATC
ACCTTGCTGCGCGATCCCGGCGTTCTGGATTCGGTCGAACGGGTGCTGGCCGGCGGCACGGCGCCGCGCCAGACCATCTG
GGTGATGCCCGGGGCGGTCGAGCGCGAGTTCGAGGTGCGGGCCACGCCCTTGCCCTCGCCCAGCATCGACGGTTCGGTCG
CCCTGCTGGGCCTGCACGACATCACCGCCCTGCGTCGGCTCGAACAGATGCGCGCCGATTTCGTCGCCAACGCCAGCCAC
GAATTGCGCACGCCGCTCTCAAGCCTGATCGGCTTCACCGAAACCCTGTCGACCAGCGCCAAGAACGATCCCGAAGCCCG
CGAGCGCTTCCTGGCAATCATGCTTGAACAGGGCCGGCGCATGCAGCGGCTGATCGAGGACCTGCTGTCGCTGTCGCGGA
TCGAAATGGAGGAGCATACCCCCCCCGACGAGGCGGTGGTCCTGCCCGGGCTGATCGCCAGCGTCACCCGTTTCCTGGAG
ATCAAGGCCCGCGAGAAAACCATGACGCTGTCGGTCGAAGCGCCGCCCGACCTGCCGCCGGCGATCGGCGACGCCGACCA
GCTGTCGCAGATTTTCCAGAACCTGCTCGACAACGCCATCAAATACGGCCGGCCGGGCACCCCGGTCGAGGTGCGGCTGG
CGGTGGTCGAGCGCGGACCGCCGGCGATGCCCGCCGGCTTGCGCGCCCCGTGCCTGCGCGTCAGCGTCATCGACCATGGC
GAGGGCATCGCCAAGGCCCATCTGCCCCGGCTGACCGAACGCTTCTACCGGGTCGACAAGGCGCGCTCGCGCGCGCTCGG
CGGCACCGGTTTGGGGCTGGCCATCGTCAAACATGTCGTCGTCCGCCACCGGGGGGCGATGACCATTGAAAGCGACCCCG
GCCTTGGCACCACGGTCAGCGTCTTCCTACCCCTGCATGGCCCGCGCCCGCCGCGGCGGGCGGCCCCTTCGGCTTAA

Upstream 100 bases:

>100_bases
GCCACCCTCGCCGCCGCCGAGGCCGGGCGTTAAGCGGCGGGCCCACCCCCGGGGGATACCCGCCCCGGGGGCGGGCCTTC
CCAGACGAAAGGACACCGCC

Downstream 100 bases:

>100_bases
GGGGGCGAGGCTGGCGTCTTTTGCGTCGCCCGCCGTTCGATGCTATGAGAAAGACCCGTTGTCACTGCCCCGGATCAGCC
CCCATGACCCCGACCCCCGA

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MDRLTPSLGRLIGAAMLVCVPATAVLLGLTLWGRLSVGVALVAGVLIWTLTALLLRSILREFMVVSRHIRGLGGRSEAGE
GAAPTPRLEIAQGLLGAAQHLDRGWRRRTQALRDQLRSDEQVLNTLPDPLLMIAKEAVVTRANEAARSLFGRDPAGQEII
TLLRDPGVLDSVERVLAGGTAPRQTIWVMPGAVEREFEVRATPLPSPSIDGSVALLGLHDITALRRLEQMRADFVANASH
ELRTPLSSLIGFTETLSTSAKNDPEARERFLAIMLEQGRRMQRLIEDLLSLSRIEMEEHTPPDEAVVLPGLIASVTRFLE
IKAREKTMTLSVEAPPDLPPAIGDADQLSQIFQNLLDNAIKYGRPGTPVEVRLAVVERGPPAMPAGLRAPCLRVSVIDHG
EGIAKAHLPRLTERFYRVDKARSRALGGTGLGLAIVKHVVVRHRGAMTIESDPGLGTTVSVFLPLHGPRPPRRAAPSA

Sequences:

>Translated_478_residues
MDRLTPSLGRLIGAAMLVCVPATAVLLGLTLWGRLSVGVALVAGVLIWTLTALLLRSILREFMVVSRHIRGLGGRSEAGE
GAAPTPRLEIAQGLLGAAQHLDRGWRRRTQALRDQLRSDEQVLNTLPDPLLMIAKEAVVTRANEAARSLFGRDPAGQEII
TLLRDPGVLDSVERVLAGGTAPRQTIWVMPGAVEREFEVRATPLPSPSIDGSVALLGLHDITALRRLEQMRADFVANASH
ELRTPLSSLIGFTETLSTSAKNDPEARERFLAIMLEQGRRMQRLIEDLLSLSRIEMEEHTPPDEAVVLPGLIASVTRFLE
IKAREKTMTLSVEAPPDLPPAIGDADQLSQIFQNLLDNAIKYGRPGTPVEVRLAVVERGPPAMPAGLRAPCLRVSVIDHG
EGIAKAHLPRLTERFYRVDKARSRALGGTGLGLAIVKHVVVRHRGAMTIESDPGLGTTVSVFLPLHGPRPPRRAAPSA
>Mature_478_residues
MDRLTPSLGRLIGAAMLVCVPATAVLLGLTLWGRLSVGVALVAGVLIWTLTALLLRSILREFMVVSRHIRGLGGRSEAGE
GAAPTPRLEIAQGLLGAAQHLDRGWRRRTQALRDQLRSDEQVLNTLPDPLLMIAKEAVVTRANEAARSLFGRDPAGQEII
TLLRDPGVLDSVERVLAGGTAPRQTIWVMPGAVEREFEVRATPLPSPSIDGSVALLGLHDITALRRLEQMRADFVANASH
ELRTPLSSLIGFTETLSTSAKNDPEARERFLAIMLEQGRRMQRLIEDLLSLSRIEMEEHTPPDEAVVLPGLIASVTRFLE
IKAREKTMTLSVEAPPDLPPAIGDADQLSQIFQNLLDNAIKYGRPGTPVEVRLAVVERGPPAMPAGLRAPCLRVSVIDHG
EGIAKAHLPRLTERFYRVDKARSRALGGTGLGLAIVKHVVVRHRGAMTIESDPGLGTTVSVFLPLHGPRPPRRAAPSA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=429, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788713, Length=394, Percent_Identity=25.3807106598985, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=31.4814814814815, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=31.8840579710145, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=32.4110671936759, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=30.0813008130081, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=30.379746835443, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=314, Percent_Identity=25.4777070063694, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=28.6852589641434, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=372, Percent_Identity=23.9247311827957, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=31.7596566523605, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=243, Percent_Identity=27.5720164609054, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=29.2887029288703, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=375, Percent_Identity=27.7333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=27.2357723577236, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789403, Length=217, Percent_Identity=29.4930875576037, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787894, Length=249, Percent_Identity=26.9076305220884, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51756; Mature: 51756

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLTPSLGRLIGAAMLVCVPATAVLLGLTLWGRLSVGVALVAGVLIWTLTALLLRSILR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFMVVSRHIRGLGGRSEAGEGAAPTPRLEIAQGLLGAAQHLDRGWRRRTQALRDQLRSDE
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QVLNTLPDPLLMIAKEAVVTRANEAARSLFGRDPAGQEIITLLRDPGVLDSVERVLAGGT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
APRQTIWVMPGAVEREFEVRATPLPSPSIDGSVALLGLHDITALRRLEQMRADFVANASH
CCCCEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHH
ELRTPLSSLIGFTETLSTSAKNDPEARERFLAIMLEQGRRMQRLIEDLLSLSRIEMEEHT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC
PPDEAVVLPGLIASVTRFLEIKAREKTMTLSVEAPPDLPPAIGDADQLSQIFQNLLDNAI
CCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
KYGRPGTPVEVRLAVVERGPPAMPAGLRAPCLRVSVIDHGEGIAKAHLPRLTERFYRVDK
HCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
ARSRALGGTGLGLAIVKHVVVRHRGAMTIESDPGLGTTVSVFLPLHGPRPPRRAAPSA
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDRLTPSLGRLIGAAMLVCVPATAVLLGLTLWGRLSVGVALVAGVLIWTLTALLLRSILR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFMVVSRHIRGLGGRSEAGEGAAPTPRLEIAQGLLGAAQHLDRGWRRRTQALRDQLRSDE
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QVLNTLPDPLLMIAKEAVVTRANEAARSLFGRDPAGQEIITLLRDPGVLDSVERVLAGGT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
APRQTIWVMPGAVEREFEVRATPLPSPSIDGSVALLGLHDITALRRLEQMRADFVANASH
CCCCEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHH
ELRTPLSSLIGFTETLSTSAKNDPEARERFLAIMLEQGRRMQRLIEDLLSLSRIEMEEHT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC
PPDEAVVLPGLIASVTRFLEIKAREKTMTLSVEAPPDLPPAIGDADQLSQIFQNLLDNAI
CCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
KYGRPGTPVEVRLAVVERGPPAMPAGLRAPCLRVSVIDHGEGIAKAHLPRLTERFYRVDK
HCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
ARSRALGGTGLGLAIVKHVVVRHRGAMTIESDPGLGTTVSVFLPLHGPRPPRRAAPSA
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]