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The map label for this gene is tme [H]

Identifier: 83594871

GI number: 83594871

Start: 4076906

End: 4079167

Strand: Direct

Name: tme [H]

Synonym: Rru_A3542

Alternate gene names: 83594871

Gene position: 4076906-4079167 (Clockwise)

Preceding gene: 83594869

Following gene: 83594872

Centisome position: 93.66

GC content: 66.0

Gene sequence:

>2262_bases
ATGGCCGACGAAACCAACCGCAATCTCGATCGTGAGGCCCTTCTGTTCCACATCACCGGCCGTCCGGGCAAGATCGAGAT
CGCCGCCACCAAGCCGCTGACCACCCAGCGCGATCTGTCGTTGGCCTATTCGCCGGGGGTGGCCGCGCCCTGCCTCGCCA
TCCAGCGCGATCCCACCACCGCTTATGATTATACCGCCAAGGGCAATATGGTCGCCGTCATCTCCAATGGCACCGCCGTG
CTCGGGCTGGGCGATCTGGGCGCCCTGGCCAGCAAGCCGGTGATGGAGGGCAAGGCGGTTCTGTTCAAGAAGTTCGCCGA
TGTCGACGGCATTGATCTTGAAGTCGATACCCGCGACGTCGATGAATTCGTCAATTGCGTGCGCTACCTGGGGCCGACCT
TCGGCGGCATCAACCTGGAAGACATCAAGGCCCCCGAATGCTTCATCATCGAGCAGCGCCTGCGCGCCCTGATGGACATC
CCCGTCTTCCATGACGACCAGCATGGCACGGCGATCATCGCCGCCGCCGGGCTGATCAACGCCCTTGACCTGTCGGGCCG
CGATATCGGCGACGCCAAGATGGTGGTCAATGGCGCCGGCGCCGCCGCCATCGCCTGCGTCGAGCTGGTCAAGGCGATGG
GCATGCGCTCGGCCAATGTCACGCTGTGCGATTCCAAGGGCGTCGTCCATCGCGGGCGCAGCGATCTCAACCAGTGGAAA
TCCGCCCACGCCATCGATACCGAAGCCCGCAGCCTGCAAGACGCCATGCGCGGCGCCGACGTGTTCTTGGGCCTGTCGGT
CAAGGGCGCGGTCACGGCCGAGATGGTGGCGACGATGGCGCCCCAGCCGATCATCTTCGCCATGGCCAACCCCGACCCGG
AAATCACCCCCGAAGACGTGCTTTCGGTGCGCGACGACGCCATCATCGCCACCGGCCGGTCGGATTATCCCAACCAGATC
AACAATGTTCTCGGCTTCCCCTATATCTTCCGCGGCGCGCTTGACGTGCGGGCCCGCACCATCAACGACGAGATGAAGAT
CGCCGCCGCCCGCGCCATCGCCGCCCTGGCCCGCGAGGACGTGCCCGACGAGGTGGCCGCCGCCTATTCGGGCCGGCGCC
TGCGCTATGGCCGCGACTATATCATCCCCGTGCCCTTCGATCCCCGGCTGATCGCCGCCATCTCCCCGGCGGTGGCCGAG
GCGGCGATGCGCTCGGGCGTCGCCCGCAAGCCGATCATCGACATCATCGGCTACCGGCGCGAGCTGTCGGCCCGCCTCGA
TCCGACGGCGGCCAGCCTGCAGGCGCTGTCGGCCCAGGTCATCAACAATCCCAAACGGGTGGCCTTCGCCGAGGGCGAAG
AGGAAAAGATGATCCGCGCCGCCCTGTCTTACCGCAATGCCGGCTATGGCACGCCGATCCTGATCGGCCGGGCCGAGAAG
ATCGCCGCCACCATGGCCGCGATGGGGCTGGGCGGCCTGGAGGGCATGGAGATCCAGAACGCCAAGCTCTCGACCCAGAC
CAAGCCTTACACCGATTACCTGTACGGCCGCCTGCAGCGCCATGGCTACCTTTATCGCGATGTCCAGCGGCTGGTGAACA
GCGACCGCAATGTCTTCGCCGCGTCGATGGTGATGCTTCAAGACGCCGACGCCATGGTGACGGGCACCATCCGCCACTTC
CACAGCTGCCTGTCCGACATCACCAAGGTCATCGATCAGACCCCGGGCGAGTTGGTGTTCTCGGTCACCTTGCTGATCGC
GCGCGGCCGCACCGTGTTCATCGCCGATACCAATGTCCACGAGGCGCCCTCGGCCCAGGAACTGGCCGATATCGCCATCC
AAACCGCCGCCCTGGCCCGGCGCATGGGTCACGAGCCGCGCGTCGCCCTGCTGTCCTATTCGACCTTCGGCGCGCCGCTC
GGCCGCACCCCCGACCGCCCGCGTCAGGCCGTCGCCCTGCTCGAGGACCGCAAGGTCGAATTCGAATTCGACGGCGAGAT
CGGCGTCCATGTCGCGCTCGATCCCGATCTGCTCAAGCTCTATCCCTTCTGCCGGCTGTCGGCGCCGGCCAATGTGCTGA
TCATGCCGGGGCTGCATTCGGCCAATATCAGTTCCAAGCTGATGCAGAAGATGGGCGGGGCGACCACCATCGGACCGGTG
CTGATGGGGCTGTCGCGGCCTTGCCAGATCGTGCCGATGGACGCCACCGTATCGGACATCGTTCACATGGCCACCCTCGC
CGCCGCCGAGGCCGGGCGTTAA

Upstream 100 bases:

>100_bases
GAGCCGGCCGGCCGCCCGGTACCAGGTTCCATATCATTGCCGCCATCAGGGCGCTCCGCAACGGACCGTCCGTCGATAAC
AATCGGGGAAACCGTCCACC

Downstream 100 bases:

>100_bases
GCGGCGGGCCCACCCCCGGGGGATACCCGCCCCGGGGGCGGGCCTTCCCAGACGAAAGGACACCGCCATGGACCGCCTGA
CCCCCTCGCTCGGCCGATTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MADETNRNLDREALLFHITGRPGKIEIAATKPLTTQRDLSLAYSPGVAAPCLAIQRDPTTAYDYTAKGNMVAVISNGTAV
LGLGDLGALASKPVMEGKAVLFKKFADVDGIDLEVDTRDVDEFVNCVRYLGPTFGGINLEDIKAPECFIIEQRLRALMDI
PVFHDDQHGTAIIAAAGLINALDLSGRDIGDAKMVVNGAGAAAIACVELVKAMGMRSANVTLCDSKGVVHRGRSDLNQWK
SAHAIDTEARSLQDAMRGADVFLGLSVKGAVTAEMVATMAPQPIIFAMANPDPEITPEDVLSVRDDAIIATGRSDYPNQI
NNVLGFPYIFRGALDVRARTINDEMKIAAARAIAALAREDVPDEVAAAYSGRRLRYGRDYIIPVPFDPRLIAAISPAVAE
AAMRSGVARKPIIDIIGYRRELSARLDPTAASLQALSAQVINNPKRVAFAEGEEEKMIRAALSYRNAGYGTPILIGRAEK
IAATMAAMGLGGLEGMEIQNAKLSTQTKPYTDYLYGRLQRHGYLYRDVQRLVNSDRNVFAASMVMLQDADAMVTGTIRHF
HSCLSDITKVIDQTPGELVFSVTLLIARGRTVFIADTNVHEAPSAQELADIAIQTAALARRMGHEPRVALLSYSTFGAPL
GRTPDRPRQAVALLEDRKVEFEFDGEIGVHVALDPDLLKLYPFCRLSAPANVLIMPGLHSANISSKLMQKMGGATTIGPV
LMGLSRPCQIVPMDATVSDIVHMATLAAAEAGR

Sequences:

>Translated_753_residues
MADETNRNLDREALLFHITGRPGKIEIAATKPLTTQRDLSLAYSPGVAAPCLAIQRDPTTAYDYTAKGNMVAVISNGTAV
LGLGDLGALASKPVMEGKAVLFKKFADVDGIDLEVDTRDVDEFVNCVRYLGPTFGGINLEDIKAPECFIIEQRLRALMDI
PVFHDDQHGTAIIAAAGLINALDLSGRDIGDAKMVVNGAGAAAIACVELVKAMGMRSANVTLCDSKGVVHRGRSDLNQWK
SAHAIDTEARSLQDAMRGADVFLGLSVKGAVTAEMVATMAPQPIIFAMANPDPEITPEDVLSVRDDAIIATGRSDYPNQI
NNVLGFPYIFRGALDVRARTINDEMKIAAARAIAALAREDVPDEVAAAYSGRRLRYGRDYIIPVPFDPRLIAAISPAVAE
AAMRSGVARKPIIDIIGYRRELSARLDPTAASLQALSAQVINNPKRVAFAEGEEEKMIRAALSYRNAGYGTPILIGRAEK
IAATMAAMGLGGLEGMEIQNAKLSTQTKPYTDYLYGRLQRHGYLYRDVQRLVNSDRNVFAASMVMLQDADAMVTGTIRHF
HSCLSDITKVIDQTPGELVFSVTLLIARGRTVFIADTNVHEAPSAQELADIAIQTAALARRMGHEPRVALLSYSTFGAPL
GRTPDRPRQAVALLEDRKVEFEFDGEIGVHVALDPDLLKLYPFCRLSAPANVLIMPGLHSANISSKLMQKMGGATTIGPV
LMGLSRPCQIVPMDATVSDIVHMATLAAAEAGR
>Mature_752_residues
ADETNRNLDREALLFHITGRPGKIEIAATKPLTTQRDLSLAYSPGVAAPCLAIQRDPTTAYDYTAKGNMVAVISNGTAVL
GLGDLGALASKPVMEGKAVLFKKFADVDGIDLEVDTRDVDEFVNCVRYLGPTFGGINLEDIKAPECFIIEQRLRALMDIP
VFHDDQHGTAIIAAAGLINALDLSGRDIGDAKMVVNGAGAAAIACVELVKAMGMRSANVTLCDSKGVVHRGRSDLNQWKS
AHAIDTEARSLQDAMRGADVFLGLSVKGAVTAEMVATMAPQPIIFAMANPDPEITPEDVLSVRDDAIIATGRSDYPNQIN
NVLGFPYIFRGALDVRARTINDEMKIAAARAIAALAREDVPDEVAAAYSGRRLRYGRDYIIPVPFDPRLIAAISPAVAEA
AMRSGVARKPIIDIIGYRRELSARLDPTAASLQALSAQVINNPKRVAFAEGEEEKMIRAALSYRNAGYGTPILIGRAEKI
AATMAAMGLGGLEGMEIQNAKLSTQTKPYTDYLYGRLQRHGYLYRDVQRLVNSDRNVFAASMVMLQDADAMVTGTIRHFH
SCLSDITKVIDQTPGELVFSVTLLIARGRTVFIADTNVHEAPSAQELADIAIQTAALARRMGHEPRVALLSYSTFGAPLG
RTPDRPRQAVALLEDRKVEFEFDGEIGVHVALDPDLLKLYPFCRLSAPANVLIMPGLHSANISSKLMQKMGGATTIGPVL
MGLSRPCQIVPMDATVSDIVHMATLAAAEAGR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=348, Percent_Identity=28.1609195402299, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI62420880, Length=348, Percent_Identity=28.1609195402299, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI239049447, Length=348, Percent_Identity=28.1609195402299, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4505143, Length=435, Percent_Identity=24.5977011494253, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1788806, Length=752, Percent_Identity=49.3351063829787, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=335, Percent_Identity=28.6567164179104, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1788800, Length=319, Percent_Identity=26.9592476489028, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI87081919, Length=333, Percent_Identity=27.3273273273273, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537199, Length=410, Percent_Identity=24.1463414634146, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646388, Length=352, Percent_Identity=27.5568181818182, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646386, Length=352, Percent_Identity=27.5568181818182, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI78707242, Length=400, Percent_Identity=25.5, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707238, Length=400, Percent_Identity=25.5, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707240, Length=400, Percent_Identity=25.5, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 80970; Mature: 80839

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADETNRNLDREALLFHITGRPGKIEIAATKPLTTQRDLSLAYSPGVAAPCLAIQRDPTT
CCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCC
AYDYTAKGNMVAVISNGTAVLGLGDLGALASKPVMEGKAVLFKKFADVDGIDLEVDTRDV
CEEEECCCCEEEEEECCEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCH
DEFVNCVRYLGPTFGGINLEDIKAPECFIIEQRLRALMDIPVFHDDQHGTAIIAAAGLIN
HHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHH
ALDLSGRDIGDAKMVVNGAGAAAIACVELVKAMGMRSANVTLCDSKGVVHRGRSDLNQWK
HHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHH
SAHAIDTEARSLQDAMRGADVFLGLSVKGAVTAEMVATMAPQPIIFAMANPDPEITPEDV
CCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LSVRDDAIIATGRSDYPNQINNVLGFPYIFRGALDVRARTINDEMKIAAARAIAALARED
HHCCCCEEEEECCCCCCHHHHHHCCCHHHHHCHHHHEEEECCHHHHHHHHHHHHHHHHCC
VPDEVAAAYSGRRLRYGRDYIIPVPFDPRLIAAISPAVAEAAMRSGVARKPIIDIIGYRR
CCHHHHHHHCCCEEECCCCEEEECCCCCCHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHH
ELSARLDPTAASLQALSAQVINNPKRVAFAEGEEEKMIRAALSYRNAGYGTPILIGRAEK
HHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECHHH
IAATMAAMGLGGLEGMEIQNAKLSTQTKPYTDYLYGRLQRHGYLYRDVQRLVNSDRNVFA
HHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEH
ASMVMLQDADAMVTGTIRHFHSCLSDITKVIDQTPGELVFSVTLLIARGRTVFIADTNVH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCC
EAPSAQELADIAIQTAALARRMGHEPRVALLSYSTFGAPLGRTPDRPRQAVALLEDRKVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHCCCEE
FEFDGEIGVHVALDPDLLKLYPFCRLSAPANVLIMPGLHSANISSKLMQKMGGATTIGPV
EEECCCEEEEEEECCHHHHHCCHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHH
LMGLSRPCQIVPMDATVSDIVHMATLAAAEAGR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADETNRNLDREALLFHITGRPGKIEIAATKPLTTQRDLSLAYSPGVAAPCLAIQRDPTT
CCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCC
AYDYTAKGNMVAVISNGTAVLGLGDLGALASKPVMEGKAVLFKKFADVDGIDLEVDTRDV
CEEEECCCCEEEEEECCEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCH
DEFVNCVRYLGPTFGGINLEDIKAPECFIIEQRLRALMDIPVFHDDQHGTAIIAAAGLIN
HHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHH
ALDLSGRDIGDAKMVVNGAGAAAIACVELVKAMGMRSANVTLCDSKGVVHRGRSDLNQWK
HHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHH
SAHAIDTEARSLQDAMRGADVFLGLSVKGAVTAEMVATMAPQPIIFAMANPDPEITPEDV
CCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LSVRDDAIIATGRSDYPNQINNVLGFPYIFRGALDVRARTINDEMKIAAARAIAALARED
HHCCCCEEEEECCCCCCHHHHHHCCCHHHHHCHHHHEEEECCHHHHHHHHHHHHHHHHCC
VPDEVAAAYSGRRLRYGRDYIIPVPFDPRLIAAISPAVAEAAMRSGVARKPIIDIIGYRR
CCHHHHHHHCCCEEECCCCEEEECCCCCCHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHH
ELSARLDPTAASLQALSAQVINNPKRVAFAEGEEEKMIRAALSYRNAGYGTPILIGRAEK
HHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECHHH
IAATMAAMGLGGLEGMEIQNAKLSTQTKPYTDYLYGRLQRHGYLYRDVQRLVNSDRNVFA
HHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEH
ASMVMLQDADAMVTGTIRHFHSCLSDITKVIDQTPGELVFSVTLLIARGRTVFIADTNVH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCC
EAPSAQELADIAIQTAALARRMGHEPRVALLSYSTFGAPLGRTPDRPRQAVALLEDRKVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHCCCEE
FEFDGEIGVHVALDPDLLKLYPFCRLSAPANVLIMPGLHSANISSKLMQKMGGATTIGPV
EEECCCEEEEEEECCHHHHHCCHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHH
LMGLSRPCQIVPMDATVSDIVHMATLAAAEAGR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]