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The map label for this gene is yvaE [H]

Identifier: 83594682

GI number: 83594682

Start: 3866604

End: 3866924

Strand: Direct

Name: yvaE [H]

Synonym: Rru_A3353

Alternate gene names: 83594682

Gene position: 3866604-3866924 (Clockwise)

Preceding gene: 83594681

Following gene: 83594686

Centisome position: 88.83

GC content: 61.68

Gene sequence:

>321_bases
ATGACCTGGCTGACCCTGACCGGCGCGATCCTGTTCGAACTGGCCGGGACTACGGCGATGAAGCTCTCGGAGGGCTTCAC
CCGGCTGCTGCCCTCGGTGGCGCTGGTGGTCTGCTATGCCATCAGCTTCACCTTGCTAACCCTGACCCTGAAGAAGATGG
ATGTCTCGATCGCCTATGCGATCTGGTCGGGGGCGGGCACGGTGCTGATCACGGTAATCGGCATTCTGGTGTTCAAGGAA
CCCGCGACCTTGCTCAAGGTGCTGTGCATCGCCCTGATCGTCGCCGGGGTGGTCGGCCTCAACCTGCTGAGCAAGCAGTA
A

Upstream 100 bases:

>100_bases
TCCCCGGCGAAACGGCGGCCCCGGCGAAGGCTGGTCCTTTGGAAGCAGCCCCCCTGGGAGAAGCCCCCCTGAAAGAAGCC
ACCCTGAAAGAAGACTGGCG

Downstream 100 bases:

>100_bases
AGCCCCTCGTCGTCGCACTCCGATCCAGAGGGCTCGGAGGTTTGCTCTAGCCGTAGCGGTGCAGGCCGGGGCCGTTTTGG
CGCAGCCATTGGCGCGCGGC

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MTWLTLTGAILFELAGTTAMKLSEGFTRLLPSVALVVCYAISFTLLTLTLKKMDVSIAYAIWSGAGTVLITVIGILVFKE
PATLLKVLCIALIVAGVVGLNLLSKQ

Sequences:

>Translated_106_residues
MTWLTLTGAILFELAGTTAMKLSEGFTRLLPSVALVVCYAISFTLLTLTLKKMDVSIAYAIWSGAGTVLITVIGILVFKE
PATLLKVLCIALIVAGVVGLNLLSKQ
>Mature_105_residues
TWLTLTGAILFELAGTTAMKLSEGFTRLLPSVALVVCYAISFTLLTLTLKKMDVSIAYAIWSGAGTVLITVIGILVFKEP
ATLLKVLCIALIVAGVVGLNLLSKQ

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=104, Percent_Identity=50, Blast_Score=92, Evalue=5e-21,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=38.2352941176471, Blast_Score=71, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11229; Mature: 11098

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLTLTGAILFELAGTTAMKLSEGFTRLLPSVALVVCYAISFTLLTLTLKKMDVSIAYA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWSGAGTVLITVIGILVFKEPATLLKVLCIALIVAGVVGLNLLSKQ
HHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWLTLTGAILFELAGTTAMKLSEGFTRLLPSVALVVCYAISFTLLTLTLKKMDVSIAYA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWSGAGTVLITVIGILVFKEPATLLKVLCIALIVAGVVGLNLLSKQ
HHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]