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The map label for this gene is hisN [H]

Identifier: 83594495

GI number: 83594495

Start: 3656736

End: 3657527

Strand: Direct

Name: hisN [H]

Synonym: Rru_A3165

Alternate gene names: 83594495

Gene position: 3656736-3657527 (Clockwise)

Preceding gene: 83594494

Following gene: 83594496

Centisome position: 84.01

GC content: 67.55

Gene sequence:

>792_bases
GTGGCCCCGCCCGTCGATGCCTTCGTTCCGCTCGTCCATCAGCTCGCCGATCTATCGGCCGCCATCATCGCTCCGCTGTT
TCGCACGCCGCTAACCGTCGACGACAAGGACGACGCCTCGCCGGTCACCGCCGCCGATCGCGATTCGGAAGCGGCGATGC
GCGAGGTGATCAGCCGCGCCTATCCCGACCATGGGGTGATCGGCGAGGAGCACGGCAGCGAACGCACCGATGCGGAATTC
GTCTGGGTGCTTGATCCCATCGATGGCACCGGCGCCTTCATCACCGGCAAGCCCAGCTTCGGCACCCTGATCGGCCTGTG
CCATAACGGCATCCCGGTGCTCGGCGCCATCAACCAGCCGATCTTGAACGAGCGCTGGATCGGCGGCCAGGGCCTGGGGG
CCAGCTTCAATGGCAAGGCCATCGCCTGCCGCCCCTGCCCCGCCCTGAACCGCGCCGCCCTTTATACGACCGCCCCCGAG
TTGTTCGCCCGCCCCGCCGATGCCGAGGCCTTTGAACGCCTGCGCCGGCGGGCCAAGCTGCGCCGTTATGGCTGCGACTG
TTACGCCTATGGGCTGGTCGCCCTCGGCTTTGCCGATCTGGTGGTGGAAACCGGCCTGAAGATTTACGACTACACCGCCC
TGGCGCCGATCGTCACCGCCGCCGGCGGCGTGATGACCGATTGGGAAAACCGCCCGCTGACCCTGGCTTCGGCCGATCGG
GTGATCGCCAGCGGCGATCTGTCCCTGCACCGCGAGGTTCTGGCGGTCATCGCCGAGCAAACGGCGCTCTAA

Upstream 100 bases:

>100_bases
GTATGGCGCTTACGCCCTGGGCTGGTAGGCCACGGGTCTCTTCCCTTCGGCCGGCGGCGGGGTTACCCTGCCCTCCCGCT
TCCGGTCTGGAGAATCCCCC

Downstream 100 bases:

>100_bases
ACCCGCTCCCCTGGCGGTTCCGCCCTATTTCGCCCACATTGGAAGGGCCCTTTGCCGGGGCTAGCTCCGTTCGACCGGGA
GACCGTGATGCGTCCCATCG

Product: histidinol-phosphate phosphatase, putative, inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAPPVDAFVPLVHQLADLSAAIIAPLFRTPLTVDDKDDASPVTAADRDSEAAMREVISRAYPDHGVIGEEHGSERTDAEF
VWVLDPIDGTGAFITGKPSFGTLIGLCHNGIPVLGAINQPILNERWIGGQGLGASFNGKAIACRPCPALNRAALYTTAPE
LFARPADAEAFERLRRRAKLRRYGCDCYAYGLVALGFADLVVETGLKIYDYTALAPIVTAAGGVMTDWENRPLTLASADR
VIASGDLSLHREVLAVIAEQTAL

Sequences:

>Translated_263_residues
MAPPVDAFVPLVHQLADLSAAIIAPLFRTPLTVDDKDDASPVTAADRDSEAAMREVISRAYPDHGVIGEEHGSERTDAEF
VWVLDPIDGTGAFITGKPSFGTLIGLCHNGIPVLGAINQPILNERWIGGQGLGASFNGKAIACRPCPALNRAALYTTAPE
LFARPADAEAFERLRRRAKLRRYGCDCYAYGLVALGFADLVVETGLKIYDYTALAPIVTAAGGVMTDWENRPLTLASADR
VIASGDLSLHREVLAVIAEQTAL
>Mature_262_residues
APPVDAFVPLVHQLADLSAAIIAPLFRTPLTVDDKDDASPVTAADRDSEAAMREVISRAYPDHGVIGEEHGSERTDAEFV
WVLDPIDGTGAFITGKPSFGTLIGLCHNGIPVLGAINQPILNERWIGGQGLGASFNGKAIACRPCPALNRAALYTTAPEL
FARPADAEAFERLRRRAKLRRYGCDCYAYGLVALGFADLVVETGLKIYDYTALAPIVTAAGGVMTDWENRPLTLASADRV
IASGDLSLHREVLAVIAEQTAL

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=269, Percent_Identity=28.6245353159851, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI221625487, Length=269, Percent_Identity=28.6245353159851, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788882, Length=215, Percent_Identity=31.1627906976744, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790659, Length=224, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193202570, Length=271, Percent_Identity=28.0442804428044, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=263, Percent_Identity=28.5171102661597, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=234, Percent_Identity=27.3504273504274, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357329, Length=232, Percent_Identity=31.4655172413793, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664918, Length=237, Percent_Identity=29.957805907173, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357957, Length=222, Percent_Identity=29.2792792792793, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357303, Length=216, Percent_Identity=30.0925925925926, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664926, Length=226, Percent_Identity=27.8761061946903, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664922, Length=228, Percent_Identity=29.8245614035088, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28069; Mature: 27938

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPVDAFVPLVHQLADLSAAIIAPLFRTPLTVDDKDDASPVTAADRDSEAAMREVISRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YPDHGVIGEEHGSERTDAEFVWVLDPIDGTGAFITGKPSFGTLIGLCHNGIPVLGAINQP
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCHHHHHHHHHCCCCEEECCCCC
ILNERWIGGQGLGASFNGKAIACRPCPALNRAALYTTAPELFARPADAEAFERLRRRAKL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECHHHHCCCCCHHHHHHHHHHHHH
RRYGCDCYAYGLVALGFADLVVETGLKIYDYTALAPIVTAAGGVMTDWENRPLTLASADR
HHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEECCCC
VIASGDLSLHREVLAVIAEQTAL
EEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
APPVDAFVPLVHQLADLSAAIIAPLFRTPLTVDDKDDASPVTAADRDSEAAMREVISRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YPDHGVIGEEHGSERTDAEFVWVLDPIDGTGAFITGKPSFGTLIGLCHNGIPVLGAINQP
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCHHHHHHHHHCCCCEEECCCCC
ILNERWIGGQGLGASFNGKAIACRPCPALNRAALYTTAPELFARPADAEAFERLRRRAKL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECHHHHCCCCCHHHHHHHHHHHHH
RRYGCDCYAYGLVALGFADLVVETGLKIYDYTALAPIVTAAGGVMTDWENRPLTLASADR
HHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEECCCC
VIASGDLSLHREVLAVIAEQTAL
EEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]