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The map label for this gene is sppA [H]

Identifier: 83593953

GI number: 83593953

Start: 3049821

End: 3051602

Strand: Reverse

Name: sppA [H]

Synonym: Rru_A2621

Alternate gene names: 83593953

Gene position: 3051602-3049821 (Counterclockwise)

Preceding gene: 83593955

Following gene: 83593947

Centisome position: 70.11

GC content: 68.74

Gene sequence:

>1782_bases
ATGCGGTTCATCGGCAAGGCCTTGCTGGTCGTTTTTGCGGTCGTCGGCATTCTGGCGAGTGTTCTTATCGTGAGTGGCGC
GGTGGCGCTCTCGTCCTTCATCGGCAAGGATGAGCCCCTGCCCACCAAATTGGTTCTCGATCTTGACGCCAGCGGATCCT
TTTCCGAAGACGGCGGCGCCCTTCCCGGCCTGGGATTCCTGTCGGGGGAGGGTGAGCGGCCCTCCTTGCGCGCGGTGACC
GAGGGGCTGATCGCCGCCGCCAGCGATCCCACGGTCAAGGGGCTGATGGTGCGCATCGGCGAGGGGTCTTTGGGTATGGC
CCAGGCCCAGGAGCTGCGTCAGGCGATCCTGGCCTTCCGCGCCTCGGGCAAGCCGTCGATCGCCTATGCCGAAACCATCG
GCGAGTTCGGTCAGGGCACGGTTCCCTATTATCTGGCTTCGGCGGTCGAGGATGTCTGGCTTCAGCCCTCGGGCATGCTG
GGCACCACCGGCTTCGCCGTGCGCATGCCCTTCGTGCGCAAGCTGCTTGATGATCTTGGCATCCTGCCGCAGTTCATCGC
CCGCAAGGAATTCAAGGACGCCGCCGCCACCGCCACCCAATATGGGATGAGCCCAGCGCAGGAGATCTCGTTTGGCGCCC
TGGTCCAGGGCTGGAGCGGGCAAGTGGTGCGCGCCGTGGCCGAGGCCCGGGGCCTGTCCGAAGATCAGGTGCGCGGGCTG
ATCGATCGCTCGCCGCTGCTGGCGGCCGAGGCCCTGGAAAGCGGCCTGATCGACCGTTTGGGCTATCCCGACGAGGCGCG
CAAGGCGATGGGCGAGCGGGCGGGAACCGACGAGCATCTGTCCGTCGGCCAGTATGCCGAGCGTCAGGCCAAGGCCAAGC
CGGCGCCCGGAGCCAAGGGTCTGGCGCTGATTGCGGCCAGCGGCCCGATCGTTACCGGCGATGGCAAGGTCAGCCCCTTC
GATGGCAAGGAAATCGATGCCCGCGCCCTGGCCGCCACCATCGATAGCGCGGTGGACGATGCCGGGGTGGCCGCCATCGT
GTTGCGTATCGACAGCCCGGGGGGATCCTATGTCGGCTCCGATCTGGTCTGGCGCGCGGTCAGCCGGGCCCGCCAGCACG
GCCTGCCGGTGATCGCCTCGATGGGCGATGTCGCCGCCTCGGGGGGCTATTACATGGCGATGGGCGCCAATAAGATCGTC
GCCCAGCCCGGCACCCTGACCGGCTCGATCGGCGTCGTCGCTGGCAAGTTCACCATCGCCAAGGCCAGCGAGGACCTAGG
CATCGCCTGGGGCGGGGTGGAGGCCGGGCGCAACGCGGCGCTGTTTAGCCTGACCGATCCCTTCGACGAGGCCGGGCAGC
GGCGCATGGATCAGATCCTTGATGCCATCTATGCCGATTTCACCGGCAAGGCGGCGGCCGGGCGCGGCCTGTCGCCCGAA
GCGATCGAAGAGGCGGCGCGCGGTCGGGTGTGGACCGGCGAGGATGCCCTGGCCCATGGGCTGGTCGATGCCCTGGGCGG
GCTGCAAACGGCGATCGAACTGGCCCGCACGGAAGCCGGTCTCGACCCCCATGCCCCCCTGGCGATCACCGTCTATCCCA
AGCGCGAGGGGCCGGAGTGGCTGTTGCGCGCCCTGATGAGCGCCGAGCAGATCGGCGGCGTGCGCAGCGTCCGGGCGGCG
CTGGGCTTGGTCAGCGGGCTGAGCAGCGAGCTTGCGCCGACGATCGACGGCCTGCGCGCCACCTCGGCCGGACCTCTGGC
CATGCCGGTGATCGGGCGCTGA

Upstream 100 bases:

>100_bases
GGGGACGCGGCCGCGCCGATAGGCCGATCCCGGCGCGGCCGGCTTGTCTCGGGGGTGGAAAGGGCTACACTGTTGGCCGC
TTATCCCCTCGGAGGACTAC

Downstream 100 bases:

>100_bases
TCATAAGAAACGGCCCGGCGGGACAATCCCGGCCGGGCCGTTGGCATGCCGAAGGGCGGCCGGTTTGCTCACACCCCGGA
GAAGCGGCCGCCGATGAGGA

Product: peptidase S49

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MRFIGKALLVVFAVVGILASVLIVSGAVALSSFIGKDEPLPTKLVLDLDASGSFSEDGGALPGLGFLSGEGERPSLRAVT
EGLIAAASDPTVKGLMVRIGEGSLGMAQAQELRQAILAFRASGKPSIAYAETIGEFGQGTVPYYLASAVEDVWLQPSGML
GTTGFAVRMPFVRKLLDDLGILPQFIARKEFKDAAATATQYGMSPAQEISFGALVQGWSGQVVRAVAEARGLSEDQVRGL
IDRSPLLAAEALESGLIDRLGYPDEARKAMGERAGTDEHLSVGQYAERQAKAKPAPGAKGLALIAASGPIVTGDGKVSPF
DGKEIDARALAATIDSAVDDAGVAAIVLRIDSPGGSYVGSDLVWRAVSRARQHGLPVIASMGDVAASGGYYMAMGANKIV
AQPGTLTGSIGVVAGKFTIAKASEDLGIAWGGVEAGRNAALFSLTDPFDEAGQRRMDQILDAIYADFTGKAAAGRGLSPE
AIEEAARGRVWTGEDALAHGLVDALGGLQTAIELARTEAGLDPHAPLAITVYPKREGPEWLLRALMSAEQIGGVRSVRAA
LGLVSGLSSELAPTIDGLRATSAGPLAMPVIGR

Sequences:

>Translated_593_residues
MRFIGKALLVVFAVVGILASVLIVSGAVALSSFIGKDEPLPTKLVLDLDASGSFSEDGGALPGLGFLSGEGERPSLRAVT
EGLIAAASDPTVKGLMVRIGEGSLGMAQAQELRQAILAFRASGKPSIAYAETIGEFGQGTVPYYLASAVEDVWLQPSGML
GTTGFAVRMPFVRKLLDDLGILPQFIARKEFKDAAATATQYGMSPAQEISFGALVQGWSGQVVRAVAEARGLSEDQVRGL
IDRSPLLAAEALESGLIDRLGYPDEARKAMGERAGTDEHLSVGQYAERQAKAKPAPGAKGLALIAASGPIVTGDGKVSPF
DGKEIDARALAATIDSAVDDAGVAAIVLRIDSPGGSYVGSDLVWRAVSRARQHGLPVIASMGDVAASGGYYMAMGANKIV
AQPGTLTGSIGVVAGKFTIAKASEDLGIAWGGVEAGRNAALFSLTDPFDEAGQRRMDQILDAIYADFTGKAAAGRGLSPE
AIEEAARGRVWTGEDALAHGLVDALGGLQTAIELARTEAGLDPHAPLAITVYPKREGPEWLLRALMSAEQIGGVRSVRAA
LGLVSGLSSELAPTIDGLRATSAGPLAMPVIGR
>Mature_593_residues
MRFIGKALLVVFAVVGILASVLIVSGAVALSSFIGKDEPLPTKLVLDLDASGSFSEDGGALPGLGFLSGEGERPSLRAVT
EGLIAAASDPTVKGLMVRIGEGSLGMAQAQELRQAILAFRASGKPSIAYAETIGEFGQGTVPYYLASAVEDVWLQPSGML
GTTGFAVRMPFVRKLLDDLGILPQFIARKEFKDAAATATQYGMSPAQEISFGALVQGWSGQVVRAVAEARGLSEDQVRGL
IDRSPLLAAEALESGLIDRLGYPDEARKAMGERAGTDEHLSVGQYAERQAKAKPAPGAKGLALIAASGPIVTGDGKVSPF
DGKEIDARALAATIDSAVDDAGVAAIVLRIDSPGGSYVGSDLVWRAVSRARQHGLPVIASMGDVAASGGYYMAMGANKIV
AQPGTLTGSIGVVAGKFTIAKASEDLGIAWGGVEAGRNAALFSLTDPFDEAGQRRMDQILDAIYADFTGKAAAGRGLSPE
AIEEAARGRVWTGEDALAHGLVDALGGLQTAIELARTEAGLDPHAPLAITVYPKREGPEWLLRALMSAEQIGGVRSVRAA
LGLVSGLSSELAPTIDGLRATSAGPLAMPVIGR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=490, Percent_Identity=32.4489795918367, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1787527, Length=163, Percent_Identity=34.9693251533742, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 61110; Mature: 61110

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFIGKALLVVFAVVGILASVLIVSGAVALSSFIGKDEPLPTKLVLDLDASGSFSEDGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCC
LPGLGFLSGEGERPSLRAVTEGLIAAASDPTVKGLMVRIGEGSLGMAQAQELRQAILAFR
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
ASGKPSIAYAETIGEFGQGTVPYYLASAVEDVWLQPSGMLGTTGFAVRMPFVRKLLDDLG
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
ILPQFIARKEFKDAAATATQYGMSPAQEISFGALVQGWSGQVVRAVAEARGLSEDQVRGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
IDRSPLLAAEALESGLIDRLGYPDEARKAMGERAGTDEHLSVGQYAERQAKAKPAPGAKG
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
LALIAASGPIVTGDGKVSPFDGKEIDARALAATIDSAVDDAGVAAIVLRIDSPGGSYVGS
EEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHH
DLVWRAVSRARQHGLPVIASMGDVAASGGYYMAMGANKIVAQPGTLTGSIGVVAGKFTIA
HHHHHHHHHHHHCCCCEEECCCCHHCCCCEEEEECCCEEEECCCCCCCCCEEEEEEEEEE
KASEDLGIAWGGVEAGRNAALFSLTDPFDEAGQRRMDQILDAIYADFTGKAAAGRGLSPE
ECCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AIEEAARGRVWTGEDALAHGLVDALGGLQTAIELARTEAGLDPHAPLAITVYPKREGPEW
HHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHH
LLRALMSAEQIGGVRSVRAALGLVSGLSSELAPTIDGLRATSAGPLAMPVIGR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFIGKALLVVFAVVGILASVLIVSGAVALSSFIGKDEPLPTKLVLDLDASGSFSEDGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCC
LPGLGFLSGEGERPSLRAVTEGLIAAASDPTVKGLMVRIGEGSLGMAQAQELRQAILAFR
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
ASGKPSIAYAETIGEFGQGTVPYYLASAVEDVWLQPSGMLGTTGFAVRMPFVRKLLDDLG
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
ILPQFIARKEFKDAAATATQYGMSPAQEISFGALVQGWSGQVVRAVAEARGLSEDQVRGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
IDRSPLLAAEALESGLIDRLGYPDEARKAMGERAGTDEHLSVGQYAERQAKAKPAPGAKG
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
LALIAASGPIVTGDGKVSPFDGKEIDARALAATIDSAVDDAGVAAIVLRIDSPGGSYVGS
EEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHH
DLVWRAVSRARQHGLPVIASMGDVAASGGYYMAMGANKIVAQPGTLTGSIGVVAGKFTIA
HHHHHHHHHHHHCCCCEEECCCCHHCCCCEEEEECCCEEEECCCCCCCCCEEEEEEEEEE
KASEDLGIAWGGVEAGRNAALFSLTDPFDEAGQRRMDQILDAIYADFTGKAAAGRGLSPE
ECCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AIEEAARGRVWTGEDALAHGLVDALGGLQTAIELARTEAGLDPHAPLAITVYPKREGPEW
HHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHH
LLRALMSAEQIGGVRSVRAALGLVSGLSSELAPTIDGLRATSAGPLAMPVIGR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]