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The map label for this gene is mutA [H]

Identifier: 83593815

GI number: 83593815

Start: 2881932

End: 2884028

Strand: Reverse

Name: mutA [H]

Synonym: Rru_A2480

Alternate gene names: 83593815

Gene position: 2884028-2881932 (Counterclockwise)

Preceding gene: 83593822

Following gene: 83593814

Centisome position: 66.26

GC content: 70.43

Gene sequence:

>2097_bases
ATGACCCAGGATATTCTCGCGCTCGCCGGCGATTTTCCGACCCTGTCCCGTGAGGCGTGGCTGGCCCTTGTCGACAAGGC
GCTGAAGGGCGCGCCGTTTGAGAAAAAGATGGTGACGAAGACCCACGAGGGGTTTTCGATCCAGCCGCTTTACACCCGGG
CCGACTGGCCCTCGACGGGTGATCCCTCGGGCTTTCCCGGGGTGATGCCCTTCACCCGCGGCGGGACCGCCGCCGGGGCG
GTGCTGCACGGTTGGGATGTGCGCCAGGAGCACGCCCATCCCGATCCCGCCGCCGCCAACGCCCAGATCCTGACCGATCT
CGAGCGCGGGGCGTCGAGCGTCACCTTGCGGTTCGATGCCGCCGGTCGCGCCGGCTTCGATAGCGATGACGCCGAGGCTG
CCGATCTGGCCGGCGTCGAGGGGATGATGATCGCCTCGCTTGACGATCTCGATACGGCCCTGGCCGGGGTCTTCCTTGAT
GGCGCGGTGGTCGGGCTGCAGGCCGGCGCCGCCTTCGAACCGGCCGCCGCCTTGCTGGCCGCCCTGTGGGCGCGCCGTCA
GATCGCCCCCGCCGCCGCCCTTGGCGCCTTCAACGCCGATCCTTTGGGCACCCTGGCCGCCACCGGAAGCCTGCCGATGA
GCGCGACGCGGGCGCTGTCGCGTCTGGGCGCCCTGGCGGCCCATACGGCGCGGAGCTATCCGCAGGCGACCGCCGTGATG
GTCGATGGCGCGCCCTATCACGATGGCGGCGCCAATGAGGTTCAGACCCTGGCCGCCGTTCTGTCCACCGGTGTCGCCTA
TCTGCGGGCGATGGAGGCGGCGGGACTTGGCATCGACGAGGCGGCGGCGCAGATGGTGTTCTCGCTGCCCCTTGATGCCG
ATATCTTCCTGGGGGTGGCCAAGCTGCGCGCCGCCCGCCGGCTGTGGGCGCGGGTTCTTGAAGCCTCGGGGGCCAGCGAG
CCGTCGCGCGCCATGCGCCTGCACGCCACCACGGCGCGGCGGGTTCTGACCCGGCGCGATCCTTGGGTGAACATGCTGCG
CGGCACGGTCAGTTGCTTTGCCGGCGCGGTGGGCGGGGCGGACAGCATCGCCGTCGCCCCCTTCGACGCCGCTTTGGGGG
TCGCCACCGATTTCTCGCGGCGCATCGCCCGCAATGTCCAGGTCATCTTGCTTGAGGAATGCAATCTCGGCCGGGTGAAC
GATCCGGCCGGCGGGTCGTGGTATGTTGAAACCCTGACCGACCGTCTGGCCCGCGAGGCCTGGAGCGCCTTCCAGGGGCT
CGAGGCCGAGGGTGGCATGGTCGCCGCCCTGGAAAGCGGCGCCCTGGCCGGGCGCATCGCCGCCACCTGGGACGATCGGC
GCAAGGCGATCGCCAAACGCAAGGATCCGCTAACCGGCGTTTCGGAATTCCCCAATCTCGCCGAAGCCCCCGTCGCCACC
GCCCCCGTCGATCTGGCCGCCTTGCGCCAAGCGGCGACAACGCGGCTGAGCGCGGCGCGTTGGGACGGTGTGGCGCCGGG
CGATTTCGCCGCGGCGATCGAAGCCGTGGGCACAGGGGCGACGCTGGGCGCCCTGGCCCGCGCCCTGGGCGATGGCGCCG
CCTTGCGGGTGCCGGCCGTTGTCCCCCATGTACTGGCCGAGGATTTCGAGGCCCTGCGCGACGCCTCCGACGACTGGCTG
GCCGCCCATGGCCAGCGGCCAAAGATCTTCCTGGCCAATCTGGGGCCGGTGGCCCAGCACACGGCGCGCGCCACCTTCGC
CAAGAACTTCTTCGAGGCCGGTGGCATTGAAGCGGTCGCCGGCGCCGGTTTCGACGAGGCCGCCGACTGCGTGGCCGCTT
GGCGCGACAGCGGGGCGAAGGTCGCCATCCTCTGTTCGTCGGACGGCCTTTATGAAACCAAGGCCGAGGATATGGCCCGG
GCGCTGAAGGCCGCCGGGGTCAGTCGGCTTTATCTGGCCGGGGCGCCCGGCGAACGCCGCGCCCTTTACGACGCCGCCGG
AGTGGATGCCTATATCCAGGCCGGATCGGATGTTCTGGGGGTGCTGGGCGACCTGCACGCCCATCTTGGCCTTGCGGTGG
AAGGATCAGCACGATGA

Upstream 100 bases:

>100_bases
AAAGGCGTCGCATGCGCTCCCCCGTTCGCTTCAGACTGGGGAGACGGCCCGACGCCCGTTACCGTCCATGTGAAGCACGA
CCGCAAAGCGACCGAATGCA

Downstream 100 bases:

>100_bases
GCCGGATTCCCGATTTCTCCAGGGTCGACCTTGAGGGGGGCGAGGCCCCCGGTTCGGCCGATCTGTGGACCGACCGGATC
GAGCATCGCGCCGGCAAGGC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MTQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTGDPSGFPGVMPFTRGGTAAGA
VLHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDAAGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLD
GAVVGLQAGAAFEPAAALLAALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVM
VDGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVAKLRAARRLWARVLEASGASE
PSRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGADSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVN
DPAGGSWYVETLTDRLAREAWSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVAT
APVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAVVPHVLAEDFEALRDASDDWL
AAHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVAGAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMAR
ALKAAGVSRLYLAGAPGERRALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR

Sequences:

>Translated_698_residues
MTQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTGDPSGFPGVMPFTRGGTAAGA
VLHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDAAGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLD
GAVVGLQAGAAFEPAAALLAALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVM
VDGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVAKLRAARRLWARVLEASGASE
PSRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGADSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVN
DPAGGSWYVETLTDRLAREAWSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVAT
APVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAVVPHVLAEDFEALRDASDDWL
AAHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVAGAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMAR
ALKAAGVSRLYLAGAPGERRALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR
>Mature_697_residues
TQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTGDPSGFPGVMPFTRGGTAAGAV
LHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDAAGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLDG
AVVGLQAGAAFEPAAALLAALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVMV
DGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVAKLRAARRLWARVLEASGASEP
SRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGADSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVND
PAGGSWYVETLTDRLAREAWSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVATA
PVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAVVPHVLAEDFEALRDASDDWLA
AHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVAGAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMARA
LKAAGVSRLYLAGAPGERRALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=586, Percent_Identity=27.4744027303754, Blast_Score=219, Evalue=5e-57,
Organism=Escherichia coli, GI1789284, Length=590, Percent_Identity=29.6610169491525, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25144500, Length=486, Percent_Identity=29.0123456790123, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 72079; Mature: 71948

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTG
CCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCC
DPSGFPGVMPFTRGGTAAGAVLHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDA
CCCCCCCCCCCCCCCCHHCHHEECCCCHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
AGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLDGAVVGLQAGAAFEPAAALLA
CCCCCCCCCCCCHHHHCCCCCEEEECHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHH
ALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVM
HHHHHHHCCCHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VDGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
KLRAARRLWARVLEASGASEPSRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGA
HHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
DSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVNDPAGGSWYVETLTDRLAREA
CCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
WSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVAT
HHHHHCCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCC
APVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHH
VPHVLAEDFEALRDASDDWLAAHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVA
HHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEC
GAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMARALKAAGVSRLYLAGAPGERR
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
ALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHCEEECCCCC
>Mature Secondary Structure 
TQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTG
CCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCC
DPSGFPGVMPFTRGGTAAGAVLHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDA
CCCCCCCCCCCCCCCCHHCHHEECCCCHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
AGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLDGAVVGLQAGAAFEPAAALLA
CCCCCCCCCCCCHHHHCCCCCEEEECHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHH
ALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVM
HHHHHHHCCCHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VDGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
KLRAARRLWARVLEASGASEPSRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGA
HHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
DSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVNDPAGGSWYVETLTDRLAREA
CCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
WSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVAT
HHHHHCCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCC
APVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHH
VPHVLAEDFEALRDASDDWLAAHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVA
HHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEC
GAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMARALKAAGVSRLYLAGAPGERR
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
ALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]