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The map label for this gene is mutB [H]

Identifier: 83593814

GI number: 83593814

Start: 2879737

End: 2881935

Strand: Reverse

Name: mutB [H]

Synonym: Rru_A2479

Alternate gene names: 83593814

Gene position: 2881935-2879737 (Counterclockwise)

Preceding gene: 83593815

Following gene: 83593813

Centisome position: 66.21

GC content: 64.3

Gene sequence:

>2199_bases
ATGAGCCGGATTCCCGATTTCTCCAGGGTCGACCTTGAGGGGGGCGAGGCCCCCGGTTCGGCCGATCTGTGGACCGACCG
GATCGAGCATCGCGCCGGCAAGGCGGTGCGCGACCTGCTGTGGACGGCGCCCGAGAAGATCGACGTCAAGCCGCTCTATC
AGGCCTCCGATCTCGACGGCCTGGATTTCCTCGATACCTATCCGGGCGCGCCGCCGTTCCTGCGCGGCCCCTATCCCAGC
ATGTATGTCAATCAGCCGTGGACGGTGCGCCAATACGCCGGTTTCTCCACCGCCACCGAATCCAACGCCTTTTACCGGCG
CAATCTGGCCGCCGGCCAGAAGGGCCTGTCGGTGGCCTTCGATCTGGCGACCCATCGCGGCTATGACAGCGACCACCCCC
GGGTGGCCGGCGATGTCGGCATGGCCGGCGTGGCCATCGACAGCATCTTCGACATGCGCACGCTGTTTGCCGGCATCCCG
CTTGATAAGATGAGCGTGTCGATGACCATGAACGGCGCCGTCTTGCCGATCATGGCCTTGTTCATTCTGGCCGGCGAGGA
ACAGGGCGTTAGCCCCGAGCAACTGTCGGGCACCATCCAGAACGACATCCTCAAAGAATTCATGGTGCGCAACACCTATA
TCTATCCGCCCACGCCCTCGATGCGGATCATCAGCGATATCTTCGCCTATACCTCCACCAAGATGCCGCGCTTCAATTCG
ATCTCGATTTCCGGCTATCACATGCAGGAAGCCGGGGCGACCGCCGATCTGGAACTGGCCTATACCCTGGCCGACGGCGT
GGAATACGCCCGCGCCGGTCTGGCCGCCGGGCTGACGATCGACGCCTTCGCCCCGCGCCTGTCGTTCTTCTGGGCGATCG
GCATGAACTTCCCCATGGAAGTCGCCAAGATGCGCGCCGCCCGCCTGCTGTGGGCCAAGCTGATCAAGGACTTCAAACCC
AAAAGCGACAAATCGCTGTCGCTGCGCACCCATTGCCAGACCTCGGGCTGGTCGCTGACCGCCCAGGATGTGTTTAACAA
CGTGACGCGCACCTGCGTCGAGGCGATGGCGGCGACCCAGGGCCATACCCAGTCGCTCCATACCAACGCCCTGGACGAGG
CCCTGGCCCTGCCCACCGATTTCTCGGCGCGCATCGCCCGCAACACCCAGTTGTTCTTGCAGCAGGAAGCCGGAACCTGC
CGGGTGATCGACCCCTGGGGCGGCAGTTACTATATCGAGCGGTTGACCCATGATCTGGCCGCCCGCGCCTGGCATTACAT
CCAGGAGGTCGAGGAGACTGGCGGCATGGCCAAGGCCATCGAGGCCGGCATCCCCAAGATGCGCATCGAAGAGGCCTCGG
CCCGCACCCAGGCGCGCATCGACAGCGGCCGTCAGACGGTGGTCGGCGTCAATAAGTACAAGGTCGACGAGGATCGTTCG
ATCGAGGTGCTGAAGGTCGAGAACGCCTCGGTCCGCCGCCAGCAGATCGAGCAACTCGAACGCCTGCGCGCCGAGCGCGA
TCCGGCCAAGGTCGAAGAGAAACTGGCGGCCCTGACCCATTCGGCGCAAAGCGGCGAAGGCAATCTTCTGGCCCTGGCCG
TCGATGCCGTGCGCGAAAAGGCGACGGTGGGCGAGGTCTCCCTGGCCCTGGAAAAGGTCTGGGGCCGTCACAAGGCCGAA
ATCCGGGCGATTTCGGGCGTCTATAGCAGCGAGGTCGGGTCGATGGCCGAAAAGGTGGCAAGCATCCGTCATCTGGTCGA
GGAGTTCGAGGCCAATGACGGCCGCCGTCCGCGCATCCTGATCGCCAAGATGGGCCAGGACGGCCACGATCGCGGCCAGA
AGGTGATCGCCACCGCCTTCGCCGATCTCGGCTTCGATGTCGATATCGGCTCGCTGTTCCAAACCCCGGCCGAAACCGCC
CGTCAGGCGGTGGAGAACGATGTCCATGTGGTCGGCGCCTCGTCGCTGGCCGCCGGCCATCTGACCCTGGTACCGCAGTT
GCGCGAGGAATTGCGCAAGCAGGGCCGCGAAGACATCATGATCGTCGTCGGCGGGGTGATCCCGCCCCAGGATTTCGACG
CCCTCTATAAGGCCGGGGCCGAGGCGATCTTTCCGCCCGGCACCAATATCGCCGAATGCGCCGTTGATCTGATGGGCAAG
CTCAACGCCCGCCTAGGCTATACCAGCAAGGCCGCGTAA

Upstream 100 bases:

>100_bases
CCGCCGGAGTGGATGCCTATATCCAGGCCGGATCGGATGTTCTGGGGGTGCTGGGCGACCTGCACGCCCATCTTGGCCTT
GCGGTGGAAGGATCAGCACG

Downstream 100 bases:

>100_bases
CCGTCGTTTCCCGCCCGTTCCGCGCGCAGCGAAAGGAACGGGCGGGATCTTTCCCCCCTTTGGTTCGGACGTTCCATGGC
AAGCCCCCCCCTGTCCGTCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MSRIPDFSRVDLEGGEAPGSADLWTDRIEHRAGKAVRDLLWTAPEKIDVKPLYQASDLDGLDFLDTYPGAPPFLRGPYPS
MYVNQPWTVRQYAGFSTATESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIFDMRTLFAGIP
LDKMSVSMTMNGAVLPIMALFILAGEEQGVSPEQLSGTIQNDILKEFMVRNTYIYPPTPSMRIISDIFAYTSTKMPRFNS
ISISGYHMQEAGATADLELAYTLADGVEYARAGLAAGLTIDAFAPRLSFFWAIGMNFPMEVAKMRAARLLWAKLIKDFKP
KSDKSLSLRTHCQTSGWSLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQEAGTC
RVIDPWGGSYYIERLTHDLAARAWHYIQEVEETGGMAKAIEAGIPKMRIEEASARTQARIDSGRQTVVGVNKYKVDEDRS
IEVLKVENASVRRQQIEQLERLRAERDPAKVEEKLAALTHSAQSGEGNLLALAVDAVREKATVGEVSLALEKVWGRHKAE
IRAISGVYSSEVGSMAEKVASIRHLVEEFEANDGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGSLFQTPAETA
RQAVENDVHVVGASSLAAGHLTLVPQLREELRKQGREDIMIVVGGVIPPQDFDALYKAGAEAIFPPGTNIAECAVDLMGK
LNARLGYTSKAA

Sequences:

>Translated_732_residues
MSRIPDFSRVDLEGGEAPGSADLWTDRIEHRAGKAVRDLLWTAPEKIDVKPLYQASDLDGLDFLDTYPGAPPFLRGPYPS
MYVNQPWTVRQYAGFSTATESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIFDMRTLFAGIP
LDKMSVSMTMNGAVLPIMALFILAGEEQGVSPEQLSGTIQNDILKEFMVRNTYIYPPTPSMRIISDIFAYTSTKMPRFNS
ISISGYHMQEAGATADLELAYTLADGVEYARAGLAAGLTIDAFAPRLSFFWAIGMNFPMEVAKMRAARLLWAKLIKDFKP
KSDKSLSLRTHCQTSGWSLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQEAGTC
RVIDPWGGSYYIERLTHDLAARAWHYIQEVEETGGMAKAIEAGIPKMRIEEASARTQARIDSGRQTVVGVNKYKVDEDRS
IEVLKVENASVRRQQIEQLERLRAERDPAKVEEKLAALTHSAQSGEGNLLALAVDAVREKATVGEVSLALEKVWGRHKAE
IRAISGVYSSEVGSMAEKVASIRHLVEEFEANDGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGSLFQTPAETA
RQAVENDVHVVGASSLAAGHLTLVPQLREELRKQGREDIMIVVGGVIPPQDFDALYKAGAEAIFPPGTNIAECAVDLMGK
LNARLGYTSKAA
>Mature_731_residues
SRIPDFSRVDLEGGEAPGSADLWTDRIEHRAGKAVRDLLWTAPEKIDVKPLYQASDLDGLDFLDTYPGAPPFLRGPYPSM
YVNQPWTVRQYAGFSTATESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIFDMRTLFAGIPL
DKMSVSMTMNGAVLPIMALFILAGEEQGVSPEQLSGTIQNDILKEFMVRNTYIYPPTPSMRIISDIFAYTSTKMPRFNSI
SISGYHMQEAGATADLELAYTLADGVEYARAGLAAGLTIDAFAPRLSFFWAIGMNFPMEVAKMRAARLLWAKLIKDFKPK
SDKSLSLRTHCQTSGWSLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQEAGTCR
VIDPWGGSYYIERLTHDLAARAWHYIQEVEETGGMAKAIEAGIPKMRIEEASARTQARIDSGRQTVVGVNKYKVDEDRSI
EVLKVENASVRRQQIEQLERLRAERDPAKVEEKLAALTHSAQSGEGNLLALAVDAVREKATVGEVSLALEKVWGRHKAEI
RAISGVYSSEVGSMAEKVASIRHLVEEFEANDGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGSLFQTPAETAR
QAVENDVHVVGASSLAAGHLTLVPQLREELRKQGREDIMIVVGGVIPPQDFDALYKAGAEAIFPPGTNIAECAVDLMGKL
NARLGYTSKAA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=694, Percent_Identity=64.2651296829971, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=696, Percent_Identity=61.7816091954023, Blast_Score=865, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=696, Percent_Identity=63.5057471264368, Blast_Score=924, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80118; Mature: 79987

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIPDFSRVDLEGGEAPGSADLWTDRIEHRAGKAVRDLLWTAPEKIDVKPLYQASDLDG
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
LDFLDTYPGAPPFLRGPYPSMYVNQPWTVRQYAGFSTATESNAFYRRNLAAGQKGLSVAF
CCHHHCCCCCCCCCCCCCCCCEECCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEE
DLATHRGYDSDHPRVAGDVGMAGVAIDSIFDMRTLFAGIPLDKMSVSMTMNGAVLPIMAL
EHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
FILAGEEQGVSPEQLSGTIQNDILKEFMVRNTYIYPPTPSMRIISDIFAYTSTKMPRFNS
HHHCCCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCE
ISISGYHMQEAGATADLELAYTLADGVEYARAGLAAGLTIDAFAPRLSFFWAIGMNFPME
EEEECEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
VAKMRAARLLWAKLIKDFKPKSDKSLSLRTHCQTSGWSLTAQDVFNNVTRTCVEAMAATQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCC
GHTQSLHTNALDEALALPTDFSARIARNTQLFLQQEAGTCRVIDPWGGSYYIERLTHDLA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH
ARAWHYIQEVEETGGMAKAIEAGIPKMRIEEASARTQARIDSGRQTVVGVNKYKVDEDRS
HHHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEEEECCEEECCCCCC
IEVLKVENASVRRQQIEQLERLRAERDPAKVEEKLAALTHSAQSGEGNLLALAVDAVREK
EEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ATVGEVSLALEKVWGRHKAEIRAISGVYSSEVGSMAEKVASIRHLVEEFEANDGRRPRIL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IAKMGQDGHDRGQKVIATAFADLGFDVDIGSLFQTPAETARQAVENDVHVVGASSLAAGH
EEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCEEEEECCHHCCCC
LTLVPQLREELRKQGREDIMIVVGGVIPPQDFDALYKAGAEAIFPPGTNIAECAVDLMGK
EEECHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHH
LNARLGYTSKAA
HHHCCCCCCCCC
>Mature Secondary Structure 
SRIPDFSRVDLEGGEAPGSADLWTDRIEHRAGKAVRDLLWTAPEKIDVKPLYQASDLDG
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
LDFLDTYPGAPPFLRGPYPSMYVNQPWTVRQYAGFSTATESNAFYRRNLAAGQKGLSVAF
CCHHHCCCCCCCCCCCCCCCCEECCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEE
DLATHRGYDSDHPRVAGDVGMAGVAIDSIFDMRTLFAGIPLDKMSVSMTMNGAVLPIMAL
EHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
FILAGEEQGVSPEQLSGTIQNDILKEFMVRNTYIYPPTPSMRIISDIFAYTSTKMPRFNS
HHHCCCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCE
ISISGYHMQEAGATADLELAYTLADGVEYARAGLAAGLTIDAFAPRLSFFWAIGMNFPME
EEEECEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
VAKMRAARLLWAKLIKDFKPKSDKSLSLRTHCQTSGWSLTAQDVFNNVTRTCVEAMAATQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCC
GHTQSLHTNALDEALALPTDFSARIARNTQLFLQQEAGTCRVIDPWGGSYYIERLTHDLA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH
ARAWHYIQEVEETGGMAKAIEAGIPKMRIEEASARTQARIDSGRQTVVGVNKYKVDEDRS
HHHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEEEECCEEECCCCCC
IEVLKVENASVRRQQIEQLERLRAERDPAKVEEKLAALTHSAQSGEGNLLALAVDAVREK
EEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ATVGEVSLALEKVWGRHKAEIRAISGVYSSEVGSMAEKVASIRHLVEEFEANDGRRPRIL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IAKMGQDGHDRGQKVIATAFADLGFDVDIGSLFQTPAETARQAVENDVHVVGASSLAAGH
EEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCEEEEECCHHCCCC
LTLVPQLREELRKQGREDIMIVVGGVIPPQDFDALYKAGAEAIFPPGTNIAECAVDLMGK
EEECHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHH
LNARLGYTSKAA
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]