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The map label for this gene is hom [H]

Identifier: 83593745

GI number: 83593745

Start: 2810164

End: 2811456

Strand: Reverse

Name: hom [H]

Synonym: Rru_A2410

Alternate gene names: 83593745

Gene position: 2811456-2810164 (Counterclockwise)

Preceding gene: 83593746

Following gene: 83593744

Centisome position: 64.59

GC content: 68.29

Gene sequence:

>1293_bases
ATGAATGATCCTTTGAAAGTCGCCGTCGCCGGCCTGGGAACGGTCGGCGCCGGGGTGGTGAAGCTGCTGGCCGACCACAA
GGACCTGCTGGCCGCCCGCGCCGGCCGGCCGGTGGTGGTCAGCGCCGTTTCGGCCCGCTCGCGCACGCGCGATCGCGGGG
TCGATCTGTCGTCCTATGCGTGGTTCGATGATCCCGTCGCCCTGGTCCGCGAGGCCAAGGCCGATGTGGTGGTCGAACTG
ATCGGCGGATCGGACGGCCCGGCCAAGGCCGTCTGCGAGACCGCCCTTGATCTTGGCCGGCCGGTGGTGACCGCCAACAA
GGCGTTGCTCGCCCACCATGGGCTGGCCCTGGCCGCCCGCGCCGAGGCGACGGGGGCGGGGCTGTGGTTCGAAGCCGCCG
TGGCCGGCGGCATTCCGATCATCAAGGCCCTGCGCGAAGGCTTGGCCGCCAACCGGATCGACGCCCTTCACGGCATCCTC
AACGGTACCTGCAATTATATCCTGACGACCATGCGCGAAAGCGGGCGGGATTTCGCCGACGTGCTAGCCGAGGCCCAGGC
TTTGGGCTATGCCGAGGCCGATCCCGGCTTTGATATCGACGGCATCGACGCCGCCCATAAGCTGGCCCTTCTCGCCAGTC
TCGCCTTCCATGTTCCGGTCGATCTGGGTGGGGTGAGCATTCAGGGCATCCGCCATATCTCGTCGCTCGATATCCGCTTC
GCCGATGAACTGGGCTATCGCATCAAATTGCTGGCGATGGCCCGGCGCACCGCCGAGGGCGTGGAACAGCGGGTGGCGCC
GGTGATGGTGCCCCTTGACGCGCCGCTCGCCCATGTCGAGGGCGTCAATAACGCCGTGGTCACCGAGGGCGACTTCGTGG
GCCGCAGCGTGTTCCAGGGGCGCGGCGCCGGGGCCGGTCCGACGGCTTCGGCCGTGGTCGCCGATCTGATCGATCTGGCG
CGCGGCCATAAGGTTCCGGTCTTTGGCGTGCCCAGCTCGGCGCTGAGCGTTCTGCCGCGCGCCGAGCCCGAGGATCATGT
CGGGCGCTATTACGTCCGACTGATGGTCGTTGACCGGCCGGGGGTTTTCGCCGAGGTGGCGGCGGCGTTGCGCGATGAAC
AGGTCTCCATGGAATCCGTTCTTCAACGCGCCCGCGATCCCGGCGAGACGGTGCCGGTGGTCATGACCCTTCATGACACC
GGCGAGGCGGCGATGACCCGGGCCCTGGCCCGCATCGGGGCGATCGACGCCATGGTCGAGCCGCCCCGCGTCATCCGCAT
CGAACAGTTCTAG

Upstream 100 bases:

>100_bases
AGGCGGTGCGCAATATCAAGGCCTTCCTGGGCGGTGGCCAGGGGGGCGAAACCGGCCTGGGCGCCAAGGGCGAGGACAAA
CAGAAGGCGGACGAAGCGGT

Downstream 100 bases:

>100_bases
AGCGGCGAGCGGAGACGGAAACAGCGATTTTCCGTCTCTTCGCCGCTCTGATCTGGTGAAACGAGAACAAAATCTCCGCG
TGACATGGGCCTCATGGAGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYAWFDDPVALVREAKADVVVEL
IGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAARAEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGIL
NGTCNYILTTMRESGRDFADVLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQGRGAGAGPTASAVVADLIDLA
RGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRPGVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDT
GEAAMTRALARIGAIDAMVEPPRVIRIEQF

Sequences:

>Translated_430_residues
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYAWFDDPVALVREAKADVVVEL
IGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAARAEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGIL
NGTCNYILTTMRESGRDFADVLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQGRGAGAGPTASAVVADLIDLA
RGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRPGVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDT
GEAAMTRALARIGAIDAMVEPPRVIRIEQF
>Mature_430_residues
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYAWFDDPVALVREAKADVVVEL
IGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAARAEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGIL
NGTCNYILTTMRESGRDFADVLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQGRGAGAGPTASAVVADLIDLA
RGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRPGVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDT
GEAAMTRALARIGAIDAMVEPPRVIRIEQF

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=245, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=96, Percent_Identity=34.375, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45047; Mature: 45047

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCC
WFDDPVALVREAKADVVVELIGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAAR
CCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCHHHHHHCCCCEEEE
AEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGILNGTCNYILTTMRESGRDFAD
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEE
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQG
HHHCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCEEECCCHHHHHHHCC
RGAGAGPTASAVVADLIDLARGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCHHHCEEEEEEEEEECC
GVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDTGEAAMTRALARIGAIDAMVE
CHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCC
PPRVIRIEQF
CCCEEEEECC
>Mature Secondary Structure
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCC
WFDDPVALVREAKADVVVELIGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAAR
CCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCHHHHHHCCCCEEEE
AEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGILNGTCNYILTTMRESGRDFAD
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEE
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQG
HHHCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCEEECCCHHHHHHHCC
RGAGAGPTASAVVADLIDLARGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCHHHCEEEEEEEEEECC
GVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDTGEAAMTRALARIGAIDAMVE
CHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCC
PPRVIRIEQF
CCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]