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The map label for this gene is 83593400

Identifier: 83593400

GI number: 83593400

Start: 2388620

End: 2389621

Strand: Direct

Name: 83593400

Synonym: Rru_A2065

Alternate gene names: NA

Gene position: 2388620-2389621 (Clockwise)

Preceding gene: 83593399

Following gene: 83593401

Centisome position: 54.88

GC content: 65.97

Gene sequence:

>1002_bases
ATGGCCCGTCATACTTTTTCGTGCATCGATGCCCATACCTGCGGCAATCCGGTGCGTCTGGTCTCGGGCGGCGCGCCCCT
GCTCACGGGGGCGACGATGATGGAGCGCCGGGCCCATTTCCTGCGTGAGTACGACTGGATCCGCACCGGTTTGATGTTCG
AGCCACGCGGCCACGACGCCATGTCGGGCAGCATCTTGTATCCGCCGACCCGCGCCGATTGCGACATCGCCATTCTCTTC
ATCGAGACCAGCGGCTGCCTGCCGATGTGTGGTCACGGCACCATCGGCACGGTCACCGTCGCCCTGGAACACGGCCTTGT
CCGCCCACGCGAGCCCGGCCTGCTGCGTCTGGACACCCCCGCCGGGGTGGTCGAGGCGCGCTATACCCAGCAAGGCGACA
AGATCACCTCGGTGCGCCTGCGCAATGTGCCGGCCTATCTGCATGGCACCGGCTATCAGGTGGAGGTTCCCGGCCTGGGG
CCGCTGACTTTCGATATCGCCTATGGCGGCAATTTCTACGCCATCATCGAGCCCCAGCCCGGCTATGCCGATCTCGACGC
CTTGTCGGTGATGGATATCCAAAGCTTCAGCCCGAAGATCCGCGCCCTGGTCAACGAGCGCTATGAGATCATCCACAAGG
CCGATCCGCGCCTGCGCGGCCTCAGCCATGTGATGTGGACGGGCAAGCCCCGCGATGCCCTGGCCCAGGGGCGCAACGCC
GTTTTCTATGGCGAGCGCGGCGTCGATCGCAGCCCCTGCGGCACCGGCACCTCGGCCCGCATGGCCCAATTGGCGGCGCG
CGGGGCTCTGGCGCCCGGCGACGCCTTCGTCCACGAAAGCATCATCGGCAGCCTGTTCCATGGCCGGGTCGAAGAGGCGA
CCACCGTTGGCGATAGCCCGGCGATCATCCCCAGCGTCGAAGGCAGCGCCTGGGTCACCGGCCTCAATACCCTCTTCCTT
TATGACGAAGAGCCCTATTCGCAGGGCTTCCTGCTGCCCTGA

Upstream 100 bases:

>100_bases
CGGGCACGGCGGCGATGATCGCCGCCCTGGCCTGTGGCGAGACGGCGCCGATCGACGCCGGCGCCTTTTCCCTCTCCCGC
TTCGCCTAAGGACCCCATCC

Downstream 100 bases:

>100_bases
CCCGCCTCCCCTTCTTTCCTTTCCCTATAAGGACCCGCCATGACCGTCGACTGGAAAGGCGTTTTCCCCGCCGTCACCAC
CAAGTTCAAAGCCGATCTTT

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MARHTFSCIDAHTCGNPVRLVSGGAPLLTGATMMERRAHFLREYDWIRTGLMFEPRGHDAMSGSILYPPTRADCDIAILF
IETSGCLPMCGHGTIGTVTVALEHGLVRPREPGLLRLDTPAGVVEARYTQQGDKITSVRLRNVPAYLHGTGYQVEVPGLG
PLTFDIAYGGNFYAIIEPQPGYADLDALSVMDIQSFSPKIRALVNERYEIIHKADPRLRGLSHVMWTGKPRDALAQGRNA
VFYGERGVDRSPCGTGTSARMAQLAARGALAPGDAFVHESIIGSLFHGRVEEATTVGDSPAIIPSVEGSAWVTGLNTLFL
YDEEPYSQGFLLP

Sequences:

>Translated_333_residues
MARHTFSCIDAHTCGNPVRLVSGGAPLLTGATMMERRAHFLREYDWIRTGLMFEPRGHDAMSGSILYPPTRADCDIAILF
IETSGCLPMCGHGTIGTVTVALEHGLVRPREPGLLRLDTPAGVVEARYTQQGDKITSVRLRNVPAYLHGTGYQVEVPGLG
PLTFDIAYGGNFYAIIEPQPGYADLDALSVMDIQSFSPKIRALVNERYEIIHKADPRLRGLSHVMWTGKPRDALAQGRNA
VFYGERGVDRSPCGTGTSARMAQLAARGALAPGDAFVHESIIGSLFHGRVEEATTVGDSPAIIPSVEGSAWVTGLNTLFL
YDEEPYSQGFLLP
>Mature_332_residues
ARHTFSCIDAHTCGNPVRLVSGGAPLLTGATMMERRAHFLREYDWIRTGLMFEPRGHDAMSGSILYPPTRADCDIAILFI
ETSGCLPMCGHGTIGTVTVALEHGLVRPREPGLLRLDTPAGVVEARYTQQGDKITSVRLRNVPAYLHGTGYQVEVPGLGP
LTFDIAYGGNFYAIIEPQPGYADLDALSVMDIQSFSPKIRALVNERYEIIHKADPRLRGLSHVMWTGKPRDALAQGRNAV
FYGERGVDRSPCGTGTSARMAQLAARGALAPGDAFVHESIIGSLFHGRVEEATTVGDSPAIIPSVEGSAWVTGLNTLFLY
DEEPYSQGFLLP

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=337, Percent_Identity=33.5311572700297, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36097; Mature: 35965

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHTFSCIDAHTCGNPVRLVSGGAPLLTGATMMERRAHFLREYDWIRTGLMFEPRGHDA
CCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCC
MSGSILYPPTRADCDIAILFIETSGCLPMCGHGTIGTVTVALEHGLVRPREPGLLRLDTP
CCCCEECCCCCCCCCEEEEEEECCCCCEECCCCCCEEEEEEEECCCCCCCCCCEEEECCC
AGVVEARYTQQGDKITSVRLRNVPAYLHGTGYQVEVPGLGPLTFDIAYGGNFYAIIEPQP
CCEEEEHECCCCCEEEEEEEECCCEEEECCCCEEECCCCCCEEEEEEECCCEEEEECCCC
GYADLDALSVMDIQSFSPKIRALVNERYEIIHKADPRLRGLSHVMWTGKPRDALAQGRNA
CCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCHHHHHCCCCE
VFYGERGVDRSPCGTGTSARMAQLAARGALAPGDAFVHESIIGSLFHGRVEEATTVGDSP
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCC
AIIPSVEGSAWVTGLNTLFLYDEEPYSQGFLLP
CEEECCCCCEEEEECEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ARHTFSCIDAHTCGNPVRLVSGGAPLLTGATMMERRAHFLREYDWIRTGLMFEPRGHDA
CCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCC
MSGSILYPPTRADCDIAILFIETSGCLPMCGHGTIGTVTVALEHGLVRPREPGLLRLDTP
CCCCEECCCCCCCCCEEEEEEECCCCCEECCCCCCEEEEEEEECCCCCCCCCCEEEECCC
AGVVEARYTQQGDKITSVRLRNVPAYLHGTGYQVEVPGLGPLTFDIAYGGNFYAIIEPQP
CCEEEEHECCCCCEEEEEEEECCCEEEECCCCEEECCCCCCEEEEEEECCCEEEEECCCC
GYADLDALSVMDIQSFSPKIRALVNERYEIIHKADPRLRGLSHVMWTGKPRDALAQGRNA
CCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCHHHHHCCCCE
VFYGERGVDRSPCGTGTSARMAQLAARGALAPGDAFVHESIIGSLFHGRVEEATTVGDSP
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCC
AIIPSVEGSAWVTGLNTLFLYDEEPYSQGFLLP
CEEECCCCCEEEEECEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA