Click here to switch to the map view.

The map label for this gene is kdsA [H]

Identifier: 83593221

GI number: 83593221

Start: 2184907

End: 2185749

Strand: Reverse

Name: kdsA [H]

Synonym: Rru_A1886

Alternate gene names: 83593221

Gene position: 2185749-2184907 (Counterclockwise)

Preceding gene: 83593222

Following gene: 83593220

Centisome position: 50.21

GC content: 65.24

Gene sequence:

>843_bases
ATGACTCCCCGCCACGTCGCCGTTGGCCCCGTCACGTTTGGTAATGATCTGCCCATGGTGCTGATCGCCGGTCCCTGTCA
GATGGAGAGCCGCGAGCACGCCCTGGAAACCGCCTCGATCCTCGTCGCCCTCTGCGCCGATCTGGGCGTGCCGTTCATCT
ACAAGACCTCGTTTGACAAGGCCAATCGCACCAGCCTGTCGGGCCAGCGCGGCGTGGGGATGGAGAAGGCCCTGCCGATC
TTCGCTGAGATCCGCGAGACCCTGGGCTGCCCGGTGCTGACCGACGTTCACGACGCCGGTCAATGCGCGCCGGTGGCCGA
AGCCGTCGATGTCTTGCAGATCCCGGCCTTCCTCTGCCGCCAGACCGATCTGCTGCTGGCGGCGGCGGCGACGGGCCGGG
TGATCAATGTCAAGAAGGGCCAGTTCCTCGCCCCCTGGGATATGAAGAACGTCGCCAACAAGGTGATGTCGGCGGGCAAC
GAGCGCGTGCTGCTCACCGAGCGCGGCGCGTCGTTTGGCTATAATACGCTGGTCACCGATATGCGCTCCTTGCCGATCAT
GGCGCGCGACACCGGCTGCCCGATCATCATCGATGCCACTCATTCGGTGCAGCAGCCGGGCGGGCAGGGGGGCTCTTCGG
GCGGGCAGCGCGAATTCGCCCCCGTCATCGCCCGTGCCGCCCTGGCCGTCGGCGTGGCCGGGGTTTTCCTGGAAACCCAT
GCCGATCCCGATCACGCGCCATCGGATGGGCCCAATATGATCGCGCTTGATGCCATGCCCGCGCTGATCGCGGTCTTGCG
CGATCTTGATGCCTTTGCCAAAAAATACCCTGTAACCCTCTGA

Upstream 100 bases:

>100_bases
TCCAGGCGGCGATTACCCAATCCCGCCTGGTCTGATCCGCCCCCGCCGACGCGGGGCCCGGGCGGGCGCCGCGCGGTTGC
CACGAGAGGTCTTCCCCCGC

Downstream 100 bases:

>100_bases
TATCAGGAGAGACCGTCGTGGCCGAGATTATCGATATCCACGCCCGCGAGATTCTGGACTCCCGCGGCAATCCCACCGTC
GAAGTCGATGTGCTGCTCGA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTPRHVAVGPVTFGNDLPMVLIAGPCQMESREHALETASILVALCADLGVPFIYKTSFDKANRTSLSGQRGVGMEKALPI
FAEIRETLGCPVLTDVHDAGQCAPVAEAVDVLQIPAFLCRQTDLLLAAAATGRVINVKKGQFLAPWDMKNVANKVMSAGN
ERVLLTERGASFGYNTLVTDMRSLPIMARDTGCPIIIDATHSVQQPGGQGGSSGGQREFAPVIARAALAVGVAGVFLETH
ADPDHAPSDGPNMIALDAMPALIAVLRDLDAFAKKYPVTL

Sequences:

>Translated_280_residues
MTPRHVAVGPVTFGNDLPMVLIAGPCQMESREHALETASILVALCADLGVPFIYKTSFDKANRTSLSGQRGVGMEKALPI
FAEIRETLGCPVLTDVHDAGQCAPVAEAVDVLQIPAFLCRQTDLLLAAAATGRVINVKKGQFLAPWDMKNVANKVMSAGN
ERVLLTERGASFGYNTLVTDMRSLPIMARDTGCPIIIDATHSVQQPGGQGGSSGGQREFAPVIARAALAVGVAGVFLETH
ADPDHAPSDGPNMIALDAMPALIAVLRDLDAFAKKYPVTL
>Mature_279_residues
TPRHVAVGPVTFGNDLPMVLIAGPCQMESREHALETASILVALCADLGVPFIYKTSFDKANRTSLSGQRGVGMEKALPIF
AEIRETLGCPVLTDVHDAGQCAPVAEAVDVLQIPAFLCRQTDLLLAAAATGRVINVKKGQFLAPWDMKNVANKVMSAGNE
RVLLTERGASFGYNTLVTDMRSLPIMARDTGCPIIIDATHSVQQPGGQGGSSGGQREFAPVIARAALAVGVAGVFLETHA
DPDHAPSDGPNMIALDAMPALIAVLRDLDAFAKKYPVTL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=277, Percent_Identity=44.4043321299639, Blast_Score=257, Evalue=6e-70,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29527; Mature: 29395

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRHVAVGPVTFGNDLPMVLIAGPCQMESREHALETASILVALCADLGVPFIYKTSFDK
CCCCEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRTSLSGQRGVGMEKALPIFAEIRETLGCPVLTDVHDAGQCAPVAEAVDVLQIPAFLCR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHC
QTDLLLAAAATGRVINVKKGQFLAPWDMKNVANKVMSAGNERVLLTERGASFGYNTLVTD
CHHHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MRSLPIMARDTGCPIIIDATHSVQQPGGQGGSSGGQREFAPVIARAALAVGVAGVFLETH
HHHCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEC
ADPDHAPSDGPNMIALDAMPALIAVLRDLDAFAKKYPVTL
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPRHVAVGPVTFGNDLPMVLIAGPCQMESREHALETASILVALCADLGVPFIYKTSFDK
CCCEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRTSLSGQRGVGMEKALPIFAEIRETLGCPVLTDVHDAGQCAPVAEAVDVLQIPAFLCR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHC
QTDLLLAAAATGRVINVKKGQFLAPWDMKNVANKVMSAGNERVLLTERGASFGYNTLVTD
CHHHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MRSLPIMARDTGCPIIIDATHSVQQPGGQGGSSGGQREFAPVIARAALAVGVAGVFLETH
HHHCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEC
ADPDHAPSDGPNMIALDAMPALIAVLRDLDAFAKKYPVTL
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA