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The map label for this gene is folK [H]

Identifier: 83593193

GI number: 83593193

Start: 2156810

End: 2157295

Strand: Reverse

Name: folK [H]

Synonym: Rru_A1858

Alternate gene names: 83593193

Gene position: 2157295-2156810 (Counterclockwise)

Preceding gene: 83593198

Following gene: 83593192

Centisome position: 49.56

GC content: 66.67

Gene sequence:

>486_bases
ATGATCTATATCGCTCTCGGCGCCAATCTGGCCGGTCCGGCCGGCTCGCCCAGGGATACACTTGACGCGGCGTTGGTCGC
CCTTGAGGACGCCGGAGTGGTGGTCGCCGCCCGCTCCGCCTGGTATCGGACGAGCCCGGTTCCACCGTCCGATCAGCCCG
ATTACGTGAACGGCGTGGCCCGTCTGGTCACCGACCTCGACCCCGTCGCCCTGCTCGGGCTGCTTCATCGCCTTGAGGAT
CAATTCGGGCGTCGGCGCGGCGAGATCAATGCCGCCCGCACCCTTGATCTCGATTTGCTTGATTATGACGAGCTGCGCCG
GACCGGGGCGCCGCCGCTGCTGCCCCATCCGCGCATGGCCGAGCGCGGTTTCGTTTTATTCCCCTTGCGCGAGATCGCGC
CCGACTGGCGCCACCCGGTTCTTGACCAACCGATCGACACCCTGATCGCCGCCCTTGCCGCCGATCAGGCGGCGGAACGT
TTGTAA

Upstream 100 bases:

>100_bases
GAAAGTAGACACACCTTATAAATCAGCGGGTCCTACCGCCCAATTACGTAAGCGTTTTGTGGGCGCGCTGCAAGCACGGC
CTTCCAGGAGAAATCGCTCG

Downstream 100 bases:

>100_bases
TCGGTCGATCTGGTTGCAAACCGCCGGCCTAGTCTCTATATATGCCGGTCCCCCGGGCAGCTTTGCGCCGCCCGGACCGT
CCCCCTGACCTTACGCTTTC

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MIYIALGANLAGPAGSPRDTLDAALVALEDAGVVVAARSAWYRTSPVPPSDQPDYVNGVARLVTDLDPVALLGLLHRLED
QFGRRRGEINAARTLDLDLLDYDELRRTGAPPLLPHPRMAERGFVLFPLREIAPDWRHPVLDQPIDTLIAALAADQAAER
L

Sequences:

>Translated_161_residues
MIYIALGANLAGPAGSPRDTLDAALVALEDAGVVVAARSAWYRTSPVPPSDQPDYVNGVARLVTDLDPVALLGLLHRLED
QFGRRRGEINAARTLDLDLLDYDELRRTGAPPLLPHPRMAERGFVLFPLREIAPDWRHPVLDQPIDTLIAALAADQAAER
L
>Mature_161_residues
MIYIALGANLAGPAGSPRDTLDAALVALEDAGVVVAARSAWYRTSPVPPSDQPDYVNGVARLVTDLDPVALLGLLHRLED
QFGRRRGEINAARTLDLDLLDYDELRRTGAPPLLPHPRMAERGFVLFPLREIAPDWRHPVLDQPIDTLIAALAADQAAER
L

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=43.1654676258993, Blast_Score=91, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17544; Mature: 17544

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIALGANLAGPAGSPRDTLDAALVALEDAGVVVAARSAWYRTSPVPPSDQPDYVNGVA
CEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
RLVTDLDPVALLGLLHRLEDQFGRRRGEINAARTLDLDLLDYDELRRTGAPPLLPHPRMA
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCHHHHHHCCCCCCCCCCCCC
ERGFVLFPLREIAPDWRHPVLDQPIDTLIAALAADQAAERL
CCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYIALGANLAGPAGSPRDTLDAALVALEDAGVVVAARSAWYRTSPVPPSDQPDYVNGVA
CEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
RLVTDLDPVALLGLLHRLEDQFGRRRGEINAARTLDLDLLDYDELRRTGAPPLLPHPRMA
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCHHHHHHCCCCCCCCCCCCC
ERGFVLFPLREIAPDWRHPVLDQPIDTLIAALAADQAAERL
CCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]