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The map label for this gene is hemB [H]

Identifier: 83593172

GI number: 83593172

Start: 2134669

End: 2135679

Strand: Direct

Name: hemB [H]

Synonym: Rru_A1837

Alternate gene names: 83593172

Gene position: 2134669-2135679 (Clockwise)

Preceding gene: 83593171

Following gene: 83593175

Centisome position: 49.04

GC content: 64.69

Gene sequence:

>1011_bases
GTGAGCATCACCATTCCCAATCTGGGCAGCTTTCCCCGTACCCGCCTGCGGCGTCCGCGCCGGGACGATTGGTCCCGTCG
CCTGCTCGCCGAAAACACCTTGACCGCCGCCGACCTGATCTGGCCGGTCTTCGTTATCGAAGGCCGCTCGGCGCGTCAGG
CCGTCGACAGCCTGCCCGGCGTCGACCGCCTGAGCATCGATCTGCTGGTCGAGGCGGCCAAGGAGGCCTTCGACCTGGGA
ATTCCGGCGATCGCCCTGTTCCCCTGCGTCGATCCCGCCCTCAAGACCCCCGACGCCGCCGAGGCCGCCAATCCGGATAA
TCTGGTTTGCCGCACGGTCCAGGCCCTTAAAAAGGCCCTGCCCGACATGGGCGTCATTTGCGACGTGGCCCTTGATCCGT
TCAATTCGGACGGTCACGACGGTTTGGTCCGCGATGGTCAGATCCTCAACGATGAAAGCGTCGAGGTGCTGTGCCGTCAG
GCCCTGGTCCAGGCCCAGGCCGGCTGCGATGTCGTCGCCCCCTCGGACATGATGGATGGCCGGGTCGCCGCCCTGCGCGA
TACCCTGGACGCCAACGACCTCGACCGCGTGCAGATCTGTTCCTATGCCGCCAAATACGCCAGCGCCTATTACGGGCCGT
TCCGCGACGCGCTCGGCTCGGGCGGGGCGCTCAAGGGCGACAAGAAGACCTATCAGATGAACCCGGCCAATTCCGATGAA
GCCCTGCGCGAAGTGGCGCTCGACATCGAGGAAGGCGCCGACATGATCATGGTCAAACCCGGCCTGCCCTATCTCGACAT
CATCCACCGGGTGAAAACCACCTTCGGCGTGCCGACCCTGGCCTATCAGGTGAGCGGGGAATACGCCATGCTCAAGGGCG
CCATCGATCGCGGCTGGCTCAAGGGCGATCTGGCCATCGAAGAAACCCTGATGGCCTTCAAACGCGCCGGCGCCGATGCC
GTCTTGACCTATTTCGCCGTCGAAATGGCCAAGATGCTCAAGGCGCGCTGA

Upstream 100 bases:

>100_bases
AGCTTGCAACCGGCGTCTCGCAGGGGTATGTCCGTCTTTCCATCGGCATCGAGCATGCCGACGATATCATTGGTGACCTG
AAACAGGCCTTGGAGTCGTT

Downstream 100 bases:

>100_bases
TTTTCGAGAGCGATGGGGGACGGGGCGGAACCGCCTTATCCCCCATCGCGGCTTTTCTGGTTAACGGCCTGGATCAAGGC
CGTTTTTTAACGCCCCTCAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSITIPNLGSFPRTRLRRPRRDDWSRRLLAENTLTAADLIWPVFVIEGRSARQAVDSLPGVDRLSIDLLVEAAKEAFDLG
IPAIALFPCVDPALKTPDAAEAANPDNLVCRTVQALKKALPDMGVICDVALDPFNSDGHDGLVRDGQILNDESVEVLCRQ
ALVQAQAGCDVVAPSDMMDGRVAALRDTLDANDLDRVQICSYAAKYASAYYGPFRDALGSGGALKGDKKTYQMNPANSDE
ALREVALDIEEGADMIMVKPGLPYLDIIHRVKTTFGVPTLAYQVSGEYAMLKGAIDRGWLKGDLAIEETLMAFKRAGADA
VLTYFAVEMAKMLKAR

Sequences:

>Translated_336_residues
MSITIPNLGSFPRTRLRRPRRDDWSRRLLAENTLTAADLIWPVFVIEGRSARQAVDSLPGVDRLSIDLLVEAAKEAFDLG
IPAIALFPCVDPALKTPDAAEAANPDNLVCRTVQALKKALPDMGVICDVALDPFNSDGHDGLVRDGQILNDESVEVLCRQ
ALVQAQAGCDVVAPSDMMDGRVAALRDTLDANDLDRVQICSYAAKYASAYYGPFRDALGSGGALKGDKKTYQMNPANSDE
ALREVALDIEEGADMIMVKPGLPYLDIIHRVKTTFGVPTLAYQVSGEYAMLKGAIDRGWLKGDLAIEETLMAFKRAGADA
VLTYFAVEMAKMLKAR
>Mature_335_residues
SITIPNLGSFPRTRLRRPRRDDWSRRLLAENTLTAADLIWPVFVIEGRSARQAVDSLPGVDRLSIDLLVEAAKEAFDLGI
PAIALFPCVDPALKTPDAAEAANPDNLVCRTVQALKKALPDMGVICDVALDPFNSDGHDGLVRDGQILNDESVEVLCRQA
LVQAQAGCDVVAPSDMMDGRVAALRDTLDANDLDRVQICSYAAKYASAYYGPFRDALGSGGALKGDKKTYQMNPANSDEA
LREVALDIEEGADMIMVKPGLPYLDIIHRVKTTFGVPTLAYQVSGEYAMLKGAIDRGWLKGDLAIEETLMAFKRAGADAV
LTYFAVEMAKMLKAR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=41.8831168831169, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=41.3249211356467, Blast_Score=221, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=37.3801916932907, Blast_Score=183, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21358291, Length=289, Percent_Identity=38.0622837370242, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36475; Mature: 36344

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIPNLGSFPRTRLRRPRRDDWSRRLLAENTLTAADLIWPVFVIEGRSARQAVDSLPG
CEEECCCCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHEECCCHHHHHHHHCCC
VDRLSIDLLVEAAKEAFDLGIPAIALFPCVDPALKTPDAAEAANPDNLVCRTVQALKKAL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCHHCCCCHHHHHHHHHHHHHHC
PDMGVICDVALDPFNSDGHDGLVRDGQILNDESVEVLCRQALVQAQAGCDVVAPSDMMDG
CCCCEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHCC
RVAALRDTLDANDLDRVQICSYAAKYASAYYGPFRDALGSGGALKGDKKTYQMNPANSDE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCHHH
ALREVALDIEEGADMIMVKPGLPYLDIIHRVKTTFGVPTLAYQVSGEYAMLKGAIDRGWL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHCCCC
KGDLAIEETLMAFKRAGADAVLTYFAVEMAKMLKAR
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SITIPNLGSFPRTRLRRPRRDDWSRRLLAENTLTAADLIWPVFVIEGRSARQAVDSLPG
EEECCCCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHEECCCHHHHHHHHCCC
VDRLSIDLLVEAAKEAFDLGIPAIALFPCVDPALKTPDAAEAANPDNLVCRTVQALKKAL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCHHCCCCHHHHHHHHHHHHHHC
PDMGVICDVALDPFNSDGHDGLVRDGQILNDESVEVLCRQALVQAQAGCDVVAPSDMMDG
CCCCEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHCC
RVAALRDTLDANDLDRVQICSYAAKYASAYYGPFRDALGSGGALKGDKKTYQMNPANSDE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCHHH
ALREVALDIEEGADMIMVKPGLPYLDIIHRVKTTFGVPTLAYQVSGEYAMLKGAIDRGWL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHCCCC
KGDLAIEETLMAFKRAGADAVLTYFAVEMAKMLKAR
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]