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The map label for this gene is ilvD [H]

Identifier: 83593121

GI number: 83593121

Start: 2076676

End: 2078553

Strand: Reverse

Name: ilvD [H]

Synonym: Rru_A1786

Alternate gene names: 83593121

Gene position: 2078553-2076676 (Counterclockwise)

Preceding gene: 83593122

Following gene: 83593118

Centisome position: 47.75

GC content: 66.45

Gene sequence:

>1878_bases
GTGATCAAGACAGGCTCAAGGCAAATGACCCCATACCGTTCCCGCACATCAACCCACGGGCGCACGATGGCCGGTGCCCG
TGGCCTTTGGCGCGCCACTGGCATGAAGGACGAGGATTTCGGCAAGCCGATCATCGCCATCGCCAATTCCTTCACCCAAT
TCGTGCCCGGCCATGTCCACCTGAAGGACATGGGCCAATTGGTGGCCGCCGAGATTGCCGCCGCCGGTGGCGTGGCCAAG
GAATTCAACACCATCGCCGTCGATGACGGCATCGCCATGGGCCATGACGGCATGCTCTATAGCCTGCCGTCGCGCGAACT
GATCGCCGATGCGGTCGAATACATGGTCAACGCCCATTGCGCCGACGCCCTGGTGTGCATTTCCAATTGCGACAAGATCA
CCCCGGGCATGCTGATGGCGGCGATGCGCCTGAACATCCCGACCATCTTCGTCTCCGGCGGGCCGATGGAAGCGGGCAAG
GTGGTGTTGGGCGGCACGGAACGCAGCGTCGATCTGATCGACGCCATGGTGGTCGCCGGCGATGCCAAGGTTTCGGATGC
CGATGTCGAGACCATCGAGCGCTCGGCCTGTCCGACCTGCGGCTCGTGTTCGGGAATGTTCACCGCCAATTCGATGAACT
GCCTGACCGAGGCCCTGGGGCTGTCGCTGCCGGGCAATGGCAGCGCCCTGGCCACCCATGTGGCGCGGCGCGGGCTGTTC
GAGGAGGCCGGACGGCGCATCGTCGATCTGGCCAAGCGACGCTATGAGCACGACGACGAAAGCACCCTGCCGCGCGCCAT
CGCCTCGTTCAAGGCCTTTGAAAACGCCATGAGCGTCGATATCGCCATGGGCGGGTCGACCAATACGGTGCTCCACCTGC
TCGCCGCCGCCCAGGAGGGCGAGGTGCCCTTCACCATGGCCGATATCGACCGGCTGTCGCGGCGCATTCCCCATCTGTGC
AAGGTTTCGCCAAGCACGGCCGACTTCTATATGGAGGATGTTCACCGCGCCGGCGGCGTCATGGGCATCATGGGCGAGTT
GTCGCGGGCCGGCCTGCTCCATGAGGACCTGCCGACGGTGCATACGCCGACGCTGAAGGCGGCGCTTGATCACTGGGATA
TCCGGCGGCCGGTCGACGACGCGGTGCGCGCCTTCTTTCGGGCGGCGCCCGGCGGCGTGCGCACCGTCGTGCCGTTTTCC
ACCGACCGCCTGTGGGACAGCCTGGACGATGACCGCGAGACCGGCTGCATCCGCGATCTCGACCACGCCTATTCCCGCGA
TGGCGGGCTGGCCGTGCTCTATGGCAATCTGGCGCCCAACGGCTGCATCGTGAAAACCGCCGGAGTCGACGCCTCGATCC
TCACCTTCACAGGCACCGTCCGCCTCTGCGAAAGCCAGGACGAGGCGGTGGCGCGTATTCTCGGCGGCGAAATTCAGGCC
GGCGACGTCGTGCTGGTGCGCTATGAGGGTCCCAAGGGCGGCCCGGGCATGCAGGAAATGCTTTATCCCACCAGCTATCT
GAAGTCGCGCGGCCTGGGCAAGGTCTGCGCCCTGGTCACCGATGGCCGTTTCTCGGGCGGCAGCTCGGGCCTGTCGATCG
GCCATGTCTCGCCGGAAGCCGCCGCTGGCGGGCCGATCGGTCTGGTCGAGGAGGGGGATATCATCGTCATCGATATCCCG
GCGCGCAGCATTGTCGTCGACCTGTCCGACGAGGAGCTGGCGGCGCGGCGAAGCGCCATGGAGGCGCGGGGACGCGCGGG
ATGGAAGCCGGCCAAACCGCGCAAGCGGGCGGTCTCTCCGGCCCTGCGCGCCTATGCGGCCCTGACCACCAGCGCCGATC
GCGGCGCCGTCCGCGACGTGTCGCAGGTCGAGCGCTAA

Upstream 100 bases:

>100_bases
GACGGCCGTTCCTGTAAGGCGGCCGGGGCGTCTTCGTACTTTGACCACCCGGGGTCGGCGGAGTAGAGTCGCCCTCCCCG
ACGGTCGGGGATTTTTTCGG

Downstream 100 bases:

>100_bases
ATCTTAAAAAAACGTCCCACAAAAAACGCCCTCCGAAGCGATTCGGAGGGCGTTTTGTTATTCTGGTCATCGAAGAAAGA
ACCCGAAGAGGCGGGTTTGC

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MIKTGSRQMTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAAEIAAAGGVAK
EFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGK
VVLGGTERSVDLIDAMVVAGDAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLF
EEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEGEVPFTMADIDRLSRRIPHLC
KVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTVHTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFS
TDRLWDSLDDDRETGCIRDLDHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQA
GDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEAAAGGPIGLVEEGDIIVIDIP
ARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSPALRAYAALTTSADRGAVRDVSQVER

Sequences:

>Translated_625_residues
MIKTGSRQMTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAAEIAAAGGVAK
EFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGK
VVLGGTERSVDLIDAMVVAGDAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLF
EEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEGEVPFTMADIDRLSRRIPHLC
KVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTVHTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFS
TDRLWDSLDDDRETGCIRDLDHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQA
GDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEAAAGGPIGLVEEGDIIVIDIP
ARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSPALRAYAALTTSADRGAVRDVSQVER
>Mature_625_residues
MIKTGSRQMTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAAEIAAAGGVAK
EFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGK
VVLGGTERSVDLIDAMVVAGDAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLF
EEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEGEVPFTMADIDRLSRRIPHLC
KVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTVHTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFS
TDRLWDSLDDDRETGCIRDLDHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQA
GDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEAAAGGPIGLVEEGDIIVIDIP
ARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSPALRAYAALTTSADRGAVRDVSQVER

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=72.520325203252, Blast_Score=927, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=548, Percent_Identity=31.9343065693431, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786464, Length=519, Percent_Identity=32.3699421965318, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=28.4658040665434, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=621, Percent_Identity=36.5539452495974, Blast_Score=343, Evalue=5e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66313; Mature: 66313

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTGSRQMTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVH
CCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEE
LKDMGQLVAAEIAAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHC
HHHHHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHH
ADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKVVLGGTERSVDLIDAMVVAG
HHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHEEC
DAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLF
CCCCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCC
EVPFTMADIDRLSRRIPHLCKVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTV
CCCEEHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCCC
HTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFSTDRLWDSLDDDRETGCIRDL
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCHHHHH
DHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQA
HHHHCCCCCEEEEECCCCCCCEEEEECCCCEEEEEEECEEEEECCHHHHHHHHHCCCCCC
GDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCC
AAGGPIGLVEEGDIIVIDIPARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSP
CCCCCEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALRAYAALTTSADRGAVRDVSQVER
HHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MIKTGSRQMTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVH
CCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEE
LKDMGQLVAAEIAAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHC
HHHHHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHH
ADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKVVLGGTERSVDLIDAMVVAG
HHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHEEC
DAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLF
CCCCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCC
EVPFTMADIDRLSRRIPHLCKVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTV
CCCEEHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCCC
HTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFSTDRLWDSLDDDRETGCIRDL
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCHHHHH
DHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQA
HHHHCCCCCEEEEECCCCCCCEEEEECCCCEEEEEEECEEEEECCHHHHHHHHHCCCCCC
GDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCC
AAGGPIGLVEEGDIIVIDIPARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSP
CCCCCEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALRAYAALTTSADRGAVRDVSQVER
HHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA