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The map label for this gene is metC [H]

Identifier: 83592948

GI number: 83592948

Start: 1906569

End: 1907747

Strand: Reverse

Name: metC [H]

Synonym: Rru_A1613

Alternate gene names: 83592948

Gene position: 1907747-1906569 (Counterclockwise)

Preceding gene: 83592950

Following gene: 83592947

Centisome position: 43.83

GC content: 65.06

Gene sequence:

>1179_bases
ATGAAACAAGATACCACCGTCGTCCATAGCGGCCGCGACCCCCAGCGGTTCGATGGCGTCGTCAATGTTCCGGCCTATCG
CGCCTCGACCGTCACCTTCCCGACCGTGGCCGACCTCAAGCGCAAGCACGCCATCCGTTTCGAGACCACCTATTACGGCC
GCTACGGCACGCCGACGACGGCCGCGCTGGAAGAGGCCGTGGCCGCCCTCGAAGGCGCGACCCATTGCGCCGCCACCTCG
TCGGGCATGGGCGCGGTGGCCGGAGCCCTGCTCACCTTCCTCAAGCAGGGCGACCACCTGTTGATGGTCGATACGGTCTA
TTGGCCGACCCGCAAGTTCTGCGATGTTTTCCTCAAGAATTTCGGCGTCGAGACCACCTATTACGATCCGCTGATCGGCG
CGGGCATCGCCGCCTTGATCCGGCCCAACACCAAGATCGTCTATTGCGAATCGCCGGGCAGCCATACCTTCCAGGTCCAG
GATATTCCCGCCATCGCGGGCGAGGCCCACGCCAAGGGCGCCCTGGTGCTGCTCGATAACACCTGGGCCTCGCCGCTTTT
CTTCGAGCCCTTTTCCAAGGGCGTCGACGTGTCGATCCAGGCGGCGACGAAATATATCGTCGGCCATTCCGACGCCATGC
TCGGCACCATTTCCGTGCGCCAGCGCGATTGGTTCCTGGCGATCAAGGACACCTTGGGCTCCTTTGGCTATGCCACCGGA
TCGGAGGAGGCCTTCCTTGGCCTGCGCGGCCTGCGCACGCTCTCGGCCCGGCTGGAGCGCCATCAGCGCTCGGCCCTGGC
GGTCGCCACTTGGCTGCAAAGCCAGCCCGAGGTCGAGCGCGTGCTTTACCCCGCCCTGCCCGATGATCCCGGCCATGCCT
TGTGGACGCGTGATTTCACCGGCGCCTCGGGGCTGTTTGGCGTGCTGCTGAAGGCGGGAACGGAAGAGCAGGTCGCCCAT
ATGCTCGACCATATGACGCTGTTCGCCATGGGCTATTCCTGGGGTGGCTATGAAAGCTTGGTCATCCCGACCCGCGGCGC
CATCGAGCGCACCGCCACCCAATGGACCCATCAGGGCCCGTCGCTGCGCCTGCATATCGGCCTGGAAGACCCGGCCGATC
TGATCGCCGATCTGCGCGCCGGCCTCGACCGCCTGGGTGAAAAGGCCCTGGATCAATGA

Upstream 100 bases:

>100_bases
CGCGAACCATCGCCGCCCAAGGGAAGGGGATGGCGCGGCGACGAAGCGGCGTTAATGTAGGGGACCCCTGCGGTTTGACG
TCCTACCCCCTGGAGTTCCC

Downstream 100 bases:

>100_bases
AGAACACCTCCGCCCTCGCCGAAACCGCCGCCCTATGGGCGGCGGTGAGGTTCACCGCCGATGGATTGGTGCCGGTCATC
GCCCAGCAGCATGACAGCGG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKQDTTVVHSGRDPQRFDGVVNVPAYRASTVTFPTVADLKRKHAIRFETTYYGRYGTPTTAALEEAVAALEGATHCAATS
SGMGAVAGALLTFLKQGDHLLMVDTVYWPTRKFCDVFLKNFGVETTYYDPLIGAGIAALIRPNTKIVYCESPGSHTFQVQ
DIPAIAGEAHAKGALVLLDNTWASPLFFEPFSKGVDVSIQAATKYIVGHSDAMLGTISVRQRDWFLAIKDTLGSFGYATG
SEEAFLGLRGLRTLSARLERHQRSALAVATWLQSQPEVERVLYPALPDDPGHALWTRDFTGASGLFGVLLKAGTEEQVAH
MLDHMTLFAMGYSWGGYESLVIPTRGAIERTATQWTHQGPSLRLHIGLEDPADLIADLRAGLDRLGEKALDQ

Sequences:

>Translated_392_residues
MKQDTTVVHSGRDPQRFDGVVNVPAYRASTVTFPTVADLKRKHAIRFETTYYGRYGTPTTAALEEAVAALEGATHCAATS
SGMGAVAGALLTFLKQGDHLLMVDTVYWPTRKFCDVFLKNFGVETTYYDPLIGAGIAALIRPNTKIVYCESPGSHTFQVQ
DIPAIAGEAHAKGALVLLDNTWASPLFFEPFSKGVDVSIQAATKYIVGHSDAMLGTISVRQRDWFLAIKDTLGSFGYATG
SEEAFLGLRGLRTLSARLERHQRSALAVATWLQSQPEVERVLYPALPDDPGHALWTRDFTGASGLFGVLLKAGTEEQVAH
MLDHMTLFAMGYSWGGYESLVIPTRGAIERTATQWTHQGPSLRLHIGLEDPADLIADLRAGLDRLGEKALDQ
>Mature_392_residues
MKQDTTVVHSGRDPQRFDGVVNVPAYRASTVTFPTVADLKRKHAIRFETTYYGRYGTPTTAALEEAVAALEGATHCAATS
SGMGAVAGALLTFLKQGDHLLMVDTVYWPTRKFCDVFLKNFGVETTYYDPLIGAGIAALIRPNTKIVYCESPGSHTFQVQ
DIPAIAGEAHAKGALVLLDNTWASPLFFEPFSKGVDVSIQAATKYIVGHSDAMLGTISVRQRDWFLAIKDTLGSFGYATG
SEEAFLGLRGLRTLSARLERHQRSALAVATWLQSQPEVERVLYPALPDDPGHALWTRDFTGASGLFGVLLKAGTEEQVAH
MLDHMTLFAMGYSWGGYESLVIPTRGAIERTATQWTHQGPSLRLHIGLEDPADLIADLRAGLDRLGEKALDQ

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=337, Percent_Identity=36.7952522255193, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI299473759, Length=337, Percent_Identity=33.5311572700297, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI25453487, Length=336, Percent_Identity=31.8452380952381, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=45.8015267175573, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1790375, Length=397, Percent_Identity=31.9899244332494, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17538055, Length=344, Percent_Identity=34.8837209302326, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17560056, Length=339, Percent_Identity=34.2182890855457, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71980708, Length=393, Percent_Identity=31.5521628498728, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=327, Percent_Identity=44.6483180428135, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319307, Length=348, Percent_Identity=32.7586206896552, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=349, Percent_Identity=28.6532951289398, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323333, Length=412, Percent_Identity=25.7281553398058, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=25.9168704156479, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=34.1085271317829, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42687; Mature: 42687

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDTTVVHSGRDPQRFDGVVNVPAYRASTVTFPTVADLKRKHAIRFETTYYGRYGTPTT
CCCCCEEEECCCCHHHHCCEEECCCCCCCEEECCHHHHHHHHCEEEEEEEEECCCCCCHH
AALEEAVAALEGATHCAATSSGMGAVAGALLTFLKQGDHLLMVDTVYWPTRKFCDVFLKN
HHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHH
FGVETTYYDPLIGAGIAALIRPNTKIVYCESPGSHTFQVQDIPAIAGEAHAKGALVLLDN
CCCCCEECCCHHHHCHHEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEEEC
TWASPLFFEPFSKGVDVSIQAATKYIVGHSDAMLGTISVRQRDWFLAIKDTLGSFGYATG
CCCCCEEECCCCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCEEEEEEHHHCCCCCCCC
SEEAFLGLRGLRTLSARLERHQRSALAVATWLQSQPEVERVLYPALPDDPGHALWTRDFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCEEEECCCC
GASGLFGVLLKAGTEEQVAHMLDHMTLFAMGYSWGGYESLVIPTRGAIERTATQWTHQGP
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
SLRLHIGLEDPADLIADLRAGLDRLGEKALDQ
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQDTTVVHSGRDPQRFDGVVNVPAYRASTVTFPTVADLKRKHAIRFETTYYGRYGTPTT
CCCCCEEEECCCCHHHHCCEEECCCCCCCEEECCHHHHHHHHCEEEEEEEEECCCCCCHH
AALEEAVAALEGATHCAATSSGMGAVAGALLTFLKQGDHLLMVDTVYWPTRKFCDVFLKN
HHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHH
FGVETTYYDPLIGAGIAALIRPNTKIVYCESPGSHTFQVQDIPAIAGEAHAKGALVLLDN
CCCCCEECCCHHHHCHHEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEEEC
TWASPLFFEPFSKGVDVSIQAATKYIVGHSDAMLGTISVRQRDWFLAIKDTLGSFGYATG
CCCCCEEECCCCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCEEEEEEHHHCCCCCCCC
SEEAFLGLRGLRTLSARLERHQRSALAVATWLQSQPEVERVLYPALPDDPGHALWTRDFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCEEEECCCC
GASGLFGVLLKAGTEEQVAHMLDHMTLFAMGYSWGGYESLVIPTRGAIERTATQWTHQGP
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
SLRLHIGLEDPADLIADLRAGLDRLGEKALDQ
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]