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The map label for this gene is hisI

Identifier: 83592947

GI number: 83592947

Start: 1906141

End: 1906572

Strand: Reverse

Name: hisI

Synonym: Rru_A1612

Alternate gene names: 83592947

Gene position: 1906572-1906141 (Counterclockwise)

Preceding gene: 83592948

Following gene: 83592946

Centisome position: 43.8

GC content: 66.2

Gene sequence:

>432_bases
ATGAAGAACACCTCCGCCCTCGCCGAAACCGCCGCCCTATGGGCGGCGGTGAGGTTCACCGCCGATGGATTGGTGCCGGT
CATCGCCCAGCAGCATGACAGCGGCGAGGTTCTGATGATGGCCTGGATGAACCGCGAGGCCCTTGAGGAAACCCTGGTGA
CTGGCAAGGCCTGTTACTGGTCGCGCTCGCGCGGACGGCTGTGGCGCAAGGGCGAAAGCTCGGGCCAGACCCAGAAGGTC
CTGGCGCTCCGCCTCGATTGCGACGGCGACACCATCTTGCTGCTTGTCGACCAGACGGGCGTGGCCTGCCATACCGGGCG
GCGCAGTTGCTTTTTCAACGAGGTCGGGCCGACAGGCGAGATCACCGTGGTCAGCGCGCCGCTGGTCACCCCCGAAGCCC
TGTACGGCGCGGAAGGACACTCCCACCCATGA

Upstream 100 bases:

>100_bases
GCCCGTCGCTGCGCCTGCATATCGGCCTGGAAGACCCGGCCGATCTGATCGCCGATCTGCGCGCCGGCCTCGACCGCCTG
GGTGAAAAGGCCCTGGATCA

Downstream 100 bases:

>100_bases
TGACCATTCCCGTAACCATCCTGACCGGTTTTTTGGGCAGCGGCAAAAGCACCTTGCTTAATCGTCTGCTGCGCCATCCG
GCGATGGGCGAAACCGCCGT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MKNTSALAETAALWAAVRFTADGLVPVIAQQHDSGEVLMMAWMNREALEETLVTGKACYWSRSRGRLWRKGESSGQTQKV
LALRLDCDGDTILLLVDQTGVACHTGRRSCFFNEVGPTGEITVVSAPLVTPEALYGAEGHSHP

Sequences:

>Translated_143_residues
MKNTSALAETAALWAAVRFTADGLVPVIAQQHDSGEVLMMAWMNREALEETLVTGKACYWSRSRGRLWRKGESSGQTQKV
LALRLDCDGDTILLLVDQTGVACHTGRRSCFFNEVGPTGEITVVSAPLVTPEALYGAEGHSHP
>Mature_143_residues
MKNTSALAETAALWAAVRFTADGLVPVIAQQHDSGEVLMMAWMNREALEETLVTGKACYWSRSRGRLWRKGESSGQTQKV
LALRLDCDGDTILLLVDQTGVACHTGRRSCFFNEVGPTGEITVVSAPLVTPEALYGAEGHSHP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=52.2222222222222, Blast_Score=104, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319819, Length=92, Percent_Identity=34.7826086956522, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_RHORT (Q2RTY3)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426699.1
- ProteinModelPortal:   Q2RTY3
- SMR:   Q2RTY3
- STRING:   Q2RTY3
- GeneID:   3835029
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1612
- NMPDR:   fig|1085.1.peg.2755
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   GRRTCFH
- BioCyc:   RRUB269796:RRU_A1612-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15488; Mature: 15488

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTSALAETAALWAAVRFTADGLVPVIAQQHDSGEVLMMAWMNREALEETLVTGKACYW
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCCEEE
SRSRGRLWRKGESSGQTQKVLALRLDCDGDTILLLVDQTGVACHTGRRSCFFNEVGPTGE
ECCCCCEEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCEEECCCCCEEECCCCCCCC
ITVVSAPLVTPEALYGAEGHSHP
EEEEECCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MKNTSALAETAALWAAVRFTADGLVPVIAQQHDSGEVLMMAWMNREALEETLVTGKACYW
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCCEEE
SRSRGRLWRKGESSGQTQKVLALRLDCDGDTILLLVDQTGVACHTGRRSCFFNEVGPTGE
ECCCCCEEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCEEECCCCCEEECCCCCCCC
ITVVSAPLVTPEALYGAEGHSHP
EEEEECCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA