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The map label for this gene is clpP

Identifier: 83592885

GI number: 83592885

Start: 1827648

End: 1828298

Strand: Direct

Name: clpP

Synonym: Rru_A1550

Alternate gene names: 83592885

Gene position: 1827648-1828298 (Clockwise)

Preceding gene: 83592884

Following gene: 83592886

Centisome position: 41.99

GC content: 59.6

Gene sequence:

>651_bases
ATGATCGACCGTGATCCGATCGACGTATTCAATAATACCCTTGTCCCCATGGTGGTGGAGCAGACCAACCGGGGCGAGCG
GTCCTATGACATTTATTCGCGCCTGCTCAAGGAGCGGATCATTTTCCTGACCGGGCAGGTCCATGATGGCGTCGCCAGCC
TGATCTGCGCCCAGTTGCTGTTCCTTGAGTCGGAAAATCCGTCGAAGGATATTTCGTTCTACATCAACTCGCCCGGGGGC
GTGGTGACCAGCGGCATGGCGATCTATGACACCATGCAATACATCCGCAGCCCGGTTTCGACCGTGTGCATCGGTCAGGC
GGCGTCGATGGGCTCGCTGCTGCTCTGCGCCGGCGAGGCGGGTAAGCGCTACGCCACCCCCAATGCCCGGATCATGATTC
ACCAGCCCTCCGGCGGCTTCCAGGGACAGGCGGCCGATATCGAGATCCAGGCCCGCGAAATCCTGGCCTTGCGCGAAAGG
CTGAACCGTATCTATGTCAAGCATACCGGTCAGCCGCTCGAAACCATCGAACGGGCCATGGATCGCGATAATTACATGAC
GGCCGAGGAATCCCGCGCCTTTGGTCTGACCGATTCCGTCATCGAACGCCGTGCGCTGTCCGACGACGGCGACACCAAGT
CTTCAAGCTAA

Upstream 100 bases:

>100_bases
CGGCAGATCCCGGGAGCGTGGATGAGTGCTCCCCGGCCCCTCTCTCCGCCGGCCGTTCCGGCCACCCAATCCGCTTGCCT
AGGGATAGTGAGACCTGGCC

Downstream 100 bases:

>100_bases
GCGACGGGACTTTAAAGGGGAAGGGGGCCAAGGTCCGCTTCCCCGGCCCGGCCAAAGGGCGGTCTCTTGGCCGGGGTCAA
TGCCGGCGCACGCGTTGCGC

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MIDRDPIDVFNNTLVPMVVEQTNRGERSYDIYSRLLKERIIFLTGQVHDGVASLICAQLLFLESENPSKDISFYINSPGG
VVTSGMAIYDTMQYIRSPVSTVCIGQAASMGSLLLCAGEAGKRYATPNARIMIHQPSGGFQGQAADIEIQAREILALRER
LNRIYVKHTGQPLETIERAMDRDNYMTAEESRAFGLTDSVIERRALSDDGDTKSSS

Sequences:

>Translated_216_residues
MIDRDPIDVFNNTLVPMVVEQTNRGERSYDIYSRLLKERIIFLTGQVHDGVASLICAQLLFLESENPSKDISFYINSPGG
VVTSGMAIYDTMQYIRSPVSTVCIGQAASMGSLLLCAGEAGKRYATPNARIMIHQPSGGFQGQAADIEIQAREILALRER
LNRIYVKHTGQPLETIERAMDRDNYMTAEESRAFGLTDSVIERRALSDDGDTKSSS
>Mature_216_residues
MIDRDPIDVFNNTLVPMVVEQTNRGERSYDIYSRLLKERIIFLTGQVHDGVASLICAQLLFLESENPSKDISFYINSPGG
VVTSGMAIYDTMQYIRSPVSTVCIGQAASMGSLLLCAGEAGKRYATPNARIMIHQPSGGFQGQAADIEIQAREILALRER
LNRIYVKHTGQPLETIERAMDRDNYMTAEESRAFGLTDSVIERRALSDDGDTKSSS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=63.8297872340426, Blast_Score=255, Evalue=2e-68,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=65.4450261780105, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=59.1397849462366, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI20129427, Length=195, Percent_Identity=61.025641025641, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_RHORT (Q2RU45)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426637.1
- ProteinModelPortal:   Q2RU45
- SMR:   Q2RU45
- STRING:   Q2RU45
- MEROPS:   S14.001
- GeneID:   3834966
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1550
- NMPDR:   fig|1085.1.peg.2819
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- PhylomeDB:   Q2RU45
- BioCyc:   RRUB269796:RRU_A1550-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23915; Mature: 23915

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 109-109 ACT_SITE 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRDPIDVFNNTLVPMVVEQTNRGERSYDIYSRLLKERIIFLTGQVHDGVASLICAQLL
CCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
FLESENPSKDISFYINSPGGVVTSGMAIYDTMQYIRSPVSTVCIGQAASMGSLLLCAGEA
HHCCCCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCC
GKRYATPNARIMIHQPSGGFQGQAADIEIQAREILALRERLNRIYVKHTGQPLETIERAM
CCEECCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHH
DRDNYMTAEESRAFGLTDSVIERRALSDDGDTKSSS
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIDRDPIDVFNNTLVPMVVEQTNRGERSYDIYSRLLKERIIFLTGQVHDGVASLICAQLL
CCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
FLESENPSKDISFYINSPGGVVTSGMAIYDTMQYIRSPVSTVCIGQAASMGSLLLCAGEA
HHCCCCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCC
GKRYATPNARIMIHQPSGGFQGQAADIEIQAREILALRERLNRIYVKHTGQPLETIERAM
CCEECCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHH
DRDNYMTAEESRAFGLTDSVIERRALSDDGDTKSSS
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA