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The map label for this gene is iscS [H]

Identifier: 83592404

GI number: 83592404

Start: 1258016

End: 1259197

Strand: Direct

Name: iscS [H]

Synonym: Rru_A1068

Alternate gene names: 83592404

Gene position: 1258016-1259197 (Clockwise)

Preceding gene: 83592403

Following gene: 83592405

Centisome position: 28.9

GC content: 69.63

Gene sequence:

>1182_bases
ATGTCCGTCGTCTATCTCGATCATAGTGCCACCACGCCGGCCGATCCCCGGGTGGTCGAGGCGATGATCCCCTTTCTCGG
CGGGATCTATGGCAACCCCTCCAGCCTGCACACCGTCGGCCGCGAGGCGCGCGCCGCCGTGCTGACCGCGCGCGCCCAGG
TCGCCGCCCTGATCGGCGCCCGGCCCGAGGACATCGTCTTCACCGCCAGCGGCACCGAGGCCGATAATCTGGCGATTTTG
GGCAGCTATGAGGCCCGCGAAAGCCAGGACTTCGCCTTGGCGGTCTCGGCGATCGAGCATCCGGCGGTTCTGGCCCCGGC
CCGGGCTGTGGAACGCCGGGGCGCGGCGCTCGAGATCGTGCCGGTTGACGGCCAGGGAACGGTCGATCCCGACCGTCTGG
CCCTGGCCTTCGCCCGCCGCCCCGCTATCGCCCTGGTCTCGGTGATGGCGGCCAATAATGTGGTCGGCACCCTTCAGGCG
CTGGAAGACCTGGGGCAGGTGGCCCACGAGAACGGCGCGCTGTTTCACACCGACGCCATCCAGGCGGCGGGCAAGGTGGC
GATCGATGTTCGCACCCTGCCCGTCGACATGCTCTCGCTGTCGGCCCACAAGCTGCACGGGCCCAAGGGGGTGGGGGCGC
TTTATCTGCGCCCGGGCGTCGCGCTCCATCCGATCATCCATGGCGGCGGCCAGGAACGCGGCTTGCGCTCGGCCACCGAA
AATGTCGCGGCCATCGTCGGCTTTGGCAAGGCGGCCGAGATCGCCCTGGCCGAAGGCGCGGCCGAGGCCGATCGCCTGCG
GGTCTTGCGCGATCACATCCTCGCCGAGGTCACCCGGCGCCTGCCCAACGCCTATCTGCTTGGCCATCCCAGCGAACGCT
TGCCCGGCCACCTGTGCCTTGGCTTCGCCGGCCAGGAGGGCGAGGCCATCCGCCTGCTGATGGCCCTTGATCAGGAAGGC
ATCGCCGTATCGAGCGGCAGCGCCTGCAGCGCCCATCGGGTCGCCGAGCCCTCCTACGTTCTTCAGGCGATGGGGTTGGA
CGCCTTTCAGGCGCGCGGATCACTGCGCGTGACCCTGGGGCGCTTCACCACGGCGGCCGAGATCGAGCGCTTCCTTGAGG
TTCTGCCCCGGGTCGTGGGCGAGCTGCGATCGATCTCCACCCGCCGCTTCGCCACTTCCTGA

Upstream 100 bases:

>100_bases
ACCTGCACGATCTGCGTCGGCAAGAAGGAGATCGGCTGGAAGGCCCATTTCGGCGTGGTGCGCTCGCTGGAGAACCAGAC
TTTCTATCGGGGGGAATGAC

Downstream 100 bases:

>100_bases
CTCCCATCGACTGCTTTGATACGGCCGAGATAAGGACCGAACCATGACTTCTCTTCAGCCCCTGCGCGCCGAGGATCTGC
CCGGCAAGAACTGCGGCGTT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSVVYLDHSATTPADPRVVEAMIPFLGGIYGNPSSLHTVGREARAAVLTARAQVAALIGARPEDIVFTASGTEADNLAIL
GSYEARESQDFALAVSAIEHPAVLAPARAVERRGAALEIVPVDGQGTVDPDRLALAFARRPAIALVSVMAANNVVGTLQA
LEDLGQVAHENGALFHTDAIQAAGKVAIDVRTLPVDMLSLSAHKLHGPKGVGALYLRPGVALHPIIHGGGQERGLRSATE
NVAAIVGFGKAAEIALAEGAAEADRLRVLRDHILAEVTRRLPNAYLLGHPSERLPGHLCLGFAGQEGEAIRLLMALDQEG
IAVSSGSACSAHRVAEPSYVLQAMGLDAFQARGSLRVTLGRFTTAAEIERFLEVLPRVVGELRSISTRRFATS

Sequences:

>Translated_393_residues
MSVVYLDHSATTPADPRVVEAMIPFLGGIYGNPSSLHTVGREARAAVLTARAQVAALIGARPEDIVFTASGTEADNLAIL
GSYEARESQDFALAVSAIEHPAVLAPARAVERRGAALEIVPVDGQGTVDPDRLALAFARRPAIALVSVMAANNVVGTLQA
LEDLGQVAHENGALFHTDAIQAAGKVAIDVRTLPVDMLSLSAHKLHGPKGVGALYLRPGVALHPIIHGGGQERGLRSATE
NVAAIVGFGKAAEIALAEGAAEADRLRVLRDHILAEVTRRLPNAYLLGHPSERLPGHLCLGFAGQEGEAIRLLMALDQEG
IAVSSGSACSAHRVAEPSYVLQAMGLDAFQARGSLRVTLGRFTTAAEIERFLEVLPRVVGELRSISTRRFATS
>Mature_392_residues
SVVYLDHSATTPADPRVVEAMIPFLGGIYGNPSSLHTVGREARAAVLTARAQVAALIGARPEDIVFTASGTEADNLAILG
SYEARESQDFALAVSAIEHPAVLAPARAVERRGAALEIVPVDGQGTVDPDRLALAFARRPAIALVSVMAANNVVGTLQAL
EDLGQVAHENGALFHTDAIQAAGKVAIDVRTLPVDMLSLSAHKLHGPKGVGALYLRPGVALHPIIHGGGQERGLRSATEN
VAAIVGFGKAAEIALAEGAAEADRLRVLRDHILAEVTRRLPNAYLLGHPSERLPGHLCLGFAGQEGEAIRLLMALDQEGI
AVSSGSACSAHRVAEPSYVLQAMGLDAFQARGSLRVTLGRFTTAAEIERFLEVLPRVVGELRSISTRRFATS

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=41.9689119170984, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI156713448, Length=430, Percent_Identity=34.8837209302326, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI48994898, Length=388, Percent_Identity=43.298969072165, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=26.9326683291771, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=26.980198019802, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=42.1188630490956, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=32.8220858895706, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=386, Percent_Identity=41.9689119170984, Blast_Score=288, Evalue=7e-79,
Organism=Drosophila melanogaster, GI20129463, Length=386, Percent_Identity=42.2279792746114, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41247; Mature: 41116

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVYLDHSATTPADPRVVEAMIPFLGGIYGNPSSLHTVGREARAAVLTARAQVAALIGA
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPEDIVFTASGTEADNLAILGSYEARESQDFALAVSAIEHPAVLAPARAVERRGAALEIV
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEHHHCCCCHHCHHHHHHHCCCEEEEE
PVDGQGTVDPDRLALAFARRPAIALVSVMAANNVVGTLQALEDLGQVAHENGALFHTDAI
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHH
QAAGKVAIDVRTLPVDMLSLSAHKLHGPKGVGALYLRPGVALHPIIHGGGQERGLRSATE
HCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHH
NVAAIVGFGKAAEIALAEGAAEADRLRVLRDHILAEVTRRLPNAYLLGHPSERLPGHLCL
CEEEEEECCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCEEEE
GFAGQEGEAIRLLMALDQEGIAVSSGSACSAHRVAEPSYVLQAMGLDAFQARGSLRVTLG
EECCCCCCEEEEEEEECCCCEEEECCCCCCHHCCCCHHHHHHHHCCHHHHCCCCEEEEEC
RFTTAAEIERFLEVLPRVVGELRSISTRRFATS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVVYLDHSATTPADPRVVEAMIPFLGGIYGNPSSLHTVGREARAAVLTARAQVAALIGA
EEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPEDIVFTASGTEADNLAILGSYEARESQDFALAVSAIEHPAVLAPARAVERRGAALEIV
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEHHHCCCCHHCHHHHHHHCCCEEEEE
PVDGQGTVDPDRLALAFARRPAIALVSVMAANNVVGTLQALEDLGQVAHENGALFHTDAI
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHH
QAAGKVAIDVRTLPVDMLSLSAHKLHGPKGVGALYLRPGVALHPIIHGGGQERGLRSATE
HCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHH
NVAAIVGFGKAAEIALAEGAAEADRLRVLRDHILAEVTRRLPNAYLLGHPSERLPGHLCL
CEEEEEECCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCEEEE
GFAGQEGEAIRLLMALDQEGIAVSSGSACSAHRVAEPSYVLQAMGLDAFQARGSLRVTLG
EECCCCCCEEEEEEEECCCCEEEECCCCCCHHCCCCHHHHHHHHCCHHHHCCCCEEEEEC
RFTTAAEIERFLEVLPRVVGELRSISTRRFATS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA