Click here to switch to the map view.

The map label for this gene is metC [H]

Identifier: 83592125

GI number: 83592125

Start: 938426

End: 939598

Strand: Reverse

Name: metC [H]

Synonym: Rru_A0786

Alternate gene names: 83592125

Gene position: 939598-938426 (Counterclockwise)

Preceding gene: 83592126

Following gene: 83592113

Centisome position: 21.59

GC content: 66.5

Gene sequence:

>1173_bases
ATGAGCGCGTCCATCATCACCACCACCAAGGGCTTCGCCACCTGGGCCGTCCACGCCGGCCATGGCGCCGATGCGACCAC
CGGCGCGGTCATGACGCCGATCTACGCCACCTCAACCTTCGCCCAATCCTCGCCGGGCAAGCATACGGGGTGGGAATACG
CTCGCTCGGGCAATCCGACCCGCGCCGCCTTTGAACGCGCCGTCGCCGAATTGGAAGGCGGCACCAACGGCTATGCCTTC
GCCTCCGGCCTCGCCGCCGAGGCGACCATTCTCGATCTGCTCGACCACGGCGCCCATATCATCGCCGGCGACGACCTGTA
CGGCGGATCCTGGCGATTGTTTGAAAAGGTGCGGGCGCGCTCGGCCGGCTTGACGGTCAGCTATGTCGATCCCAGCGACC
TTGGCGCCGTGGCCCAGGCGATCACCCCGCAGACCAAGCTGATCTGGATCGAAACGCCAAGCAATCCGCTGCTCAAGATC
GCCGACCTCGCGGCTTTGGCCGCCTTGGCCAAGGAGCATGGCCTGCGCACGGTGGTCGATTCGACCTTCGCCACGCCGTG
GATCCAGCGCCCCCTTGATCTTGGCATCGATATCGTCGTCCATTCGGCGACCAAATACCTGAACGGTCATTCCGACGTGA
TCGCCGGGGTGGTGGTGGTCAAGGATCCCGATCTCGCCAGCCAGTTGGGCTTCCTGCAAAACGCCACCGGCGCCGTGCTC
GATCCCTTCGCCGCCTTCCTGGCCCTGCGCGGCCTGAAGACCCTGGCCCTGCGCATGGACCGCCATTCGGCCAATGGCTT
GGCCGTCGCCCATGCCCTGGAAGGCCGGGCCAAGGTTCGCCGCGTGCTTTATCCCGGCCTCGCCAGCCACCCCCAGCACG
CACTGGCCCGCCAGCAGATGCGCGCCTTCGGCGGCATGCTCACCCTGGATCTCGAGAGCGATCTGGCCGGAACCGTGCGC
TTCCTGGAAGCCTTGAAACTGTTCACCCTGGCCGAAAGCCTGGGCGGCGTGGAAAGCCTAGCCGGCCATCCGGTGACCAT
GAGCCACGGATCGATCCCGGTCGAACGCCGGACGGCCCTTGGCATCACCGACACCCTGGTCCGCCTGTCGGTCGGCATCG
AAGACGCCGGCGATCTGATCGCCGATCTCGATCAGGCGCTGGCCGTCGTCTGA

Upstream 100 bases:

>100_bases
TGTTCGATCGCGGACGCGTCGCCATCGTTGTCGATGACAGCGGTTTCCTCGGGCTGATCACCCGCATCGATTTCCTGAAC
CATCTAAGGGGCAAAGCCGC

Downstream 100 bases:

>100_bases
GCCTCCCCGACCAAGACAAAAGCCCCCCGGGACCGATCCTCCCGGGGGGCTTTTCGTTAGGGCAAATCCCGAGCGATCTG
AGCCAGAGTGCGACGACGAT

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSASIITTTKGFATWAVHAGHGADATTGAVMTPIYATSTFAQSSPGKHTGWEYARSGNPTRAAFERAVAELEGGTNGYAF
ASGLAAEATILDLLDHGAHIIAGDDLYGGSWRLFEKVRARSAGLTVSYVDPSDLGAVAQAITPQTKLIWIETPSNPLLKI
ADLAALAALAKEHGLRTVVDSTFATPWIQRPLDLGIDIVVHSATKYLNGHSDVIAGVVVVKDPDLASQLGFLQNATGAVL
DPFAAFLALRGLKTLALRMDRHSANGLAVAHALEGRAKVRRVLYPGLASHPQHALARQQMRAFGGMLTLDLESDLAGTVR
FLEALKLFTLAESLGGVESLAGHPVTMSHGSIPVERRTALGITDTLVRLSVGIEDAGDLIADLDQALAVV

Sequences:

>Translated_390_residues
MSASIITTTKGFATWAVHAGHGADATTGAVMTPIYATSTFAQSSPGKHTGWEYARSGNPTRAAFERAVAELEGGTNGYAF
ASGLAAEATILDLLDHGAHIIAGDDLYGGSWRLFEKVRARSAGLTVSYVDPSDLGAVAQAITPQTKLIWIETPSNPLLKI
ADLAALAALAKEHGLRTVVDSTFATPWIQRPLDLGIDIVVHSATKYLNGHSDVIAGVVVVKDPDLASQLGFLQNATGAVL
DPFAAFLALRGLKTLALRMDRHSANGLAVAHALEGRAKVRRVLYPGLASHPQHALARQQMRAFGGMLTLDLESDLAGTVR
FLEALKLFTLAESLGGVESLAGHPVTMSHGSIPVERRTALGITDTLVRLSVGIEDAGDLIADLDQALAVV
>Mature_389_residues
SASIITTTKGFATWAVHAGHGADATTGAVMTPIYATSTFAQSSPGKHTGWEYARSGNPTRAAFERAVAELEGGTNGYAFA
SGLAAEATILDLLDHGAHIIAGDDLYGGSWRLFEKVRARSAGLTVSYVDPSDLGAVAQAITPQTKLIWIETPSNPLLKIA
DLAALAALAKEHGLRTVVDSTFATPWIQRPLDLGIDIVVHSATKYLNGHSDVIAGVVVVKDPDLASQLGFLQNATGAVLD
PFAAFLALRGLKTLALRMDRHSANGLAVAHALEGRAKVRRVLYPGLASHPQHALARQQMRAFGGMLTLDLESDLAGTVRF
LEALKLFTLAESLGGVESLAGHPVTMSHGSIPVERRTALGITDTLVRLSVGIEDAGDLIADLDQALAVV

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=378, Percent_Identity=52.3809523809524, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI299473759, Length=378, Percent_Identity=47.3544973544974, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI25453487, Length=377, Percent_Identity=46.9496021220159, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=43.421052631579, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1789383, Length=402, Percent_Identity=30.5970149253731, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17538055, Length=387, Percent_Identity=47.8036175710594, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17560056, Length=387, Percent_Identity=47.5452196382429, Blast_Score=358, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI71980708, Length=369, Percent_Identity=41.7344173441734, Blast_Score=271, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=47.1354166666667, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=401, Percent_Identity=34.9127182044888, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=32.3394495412844, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=326, Percent_Identity=31.5950920245399, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=344, Percent_Identity=31.3953488372093, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922554, Length=384, Percent_Identity=49.21875, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 40961; Mature: 40830

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASIITTTKGFATWAVHAGHGADATTGAVMTPIYATSTFAQSSPGKHTGWEYARSGNPT
CCCCEEEECCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHCCCCCCCCCCHHHHCCCCH
RAAFERAVAELEGGTNGYAFASGLAAEATILDLLDHGAHIIAGDDLYGGSWRLFEKVRAR
HHHHHHHHHHHCCCCCCEEHHCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
SAGLTVSYVDPSDLGAVAQAITPQTKLIWIETPSNPLLKIADLAALAALAKEHGLRTVVD
HCCCEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHH
STFATPWIQRPLDLGIDIVVHSATKYLNGHSDVIAGVVVVKDPDLASQLGFLQNATGAVL
HHHCCHHHCCHHHCCEEEEEEHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHH
DPFAAFLALRGLKTLALRMDRHSANGLAVAHALEGRAKVRRVLYPGLASHPQHALARQQM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RAFGGMLTLDLESDLAGTVRFLEALKLFTLAESLGGVESLAGHPVTMSHGSIPVERRTAL
HHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCCHHHHC
GITDTLVRLSVGIEDAGDLIADLDQALAVV
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASIITTTKGFATWAVHAGHGADATTGAVMTPIYATSTFAQSSPGKHTGWEYARSGNPT
CCCEEEECCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHCCCCCCCCCCHHHHCCCCH
RAAFERAVAELEGGTNGYAFASGLAAEATILDLLDHGAHIIAGDDLYGGSWRLFEKVRAR
HHHHHHHHHHHCCCCCCEEHHCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
SAGLTVSYVDPSDLGAVAQAITPQTKLIWIETPSNPLLKIADLAALAALAKEHGLRTVVD
HCCCEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHH
STFATPWIQRPLDLGIDIVVHSATKYLNGHSDVIAGVVVVKDPDLASQLGFLQNATGAVL
HHHCCHHHCCHHHCCEEEEEEHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHH
DPFAAFLALRGLKTLALRMDRHSANGLAVAHALEGRAKVRRVLYPGLASHPQHALARQQM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RAFGGMLTLDLESDLAGTVRFLEALKLFTLAESLGGVESLAGHPVTMSHGSIPVERRTAL
HHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCCHHHHC
GITDTLVRLSVGIEDAGDLIADLDQALAVV
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]